Liposomes for Tumor Targeted Therapy: A Review
Liposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped vesicles consisting of one or more phospholipid bilayers. Compared with traditional drug delivery systems, liposomes exhibit prominent properties that include targeted delivery, high biocompatibility, biodegrad...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/2643 |
| _version_ | 1797624350038294528 |
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| author | Shile Wang Yanyu Chen Jiancheng Guo Qinqin Huang |
| author_facet | Shile Wang Yanyu Chen Jiancheng Guo Qinqin Huang |
| author_sort | Shile Wang |
| collection | DOAJ |
| description | Liposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped vesicles consisting of one or more phospholipid bilayers. Compared with traditional drug delivery systems, liposomes exhibit prominent properties that include targeted delivery, high biocompatibility, biodegradability, easy functionalization, low toxicity, improvements in the sustained release of the drug it carries and improved therapeutic indices. In the wake of the rapid development of nanotechnology, the studies of liposome composition have become increasingly extensive. The molecular diversity of liposome composition, which includes long-circulating PEGylated liposomes, ligand-functionalized liposomes, stimuli-responsive liposomes, and advanced cell membrane-coated biomimetic nanocarriers, endows their drug delivery with unique physiological functions. This review describes the composition, types and preparation methods of liposomes, and discusses their targeting strategies in cancer therapy. |
| first_indexed | 2024-03-11T09:41:08Z |
| format | Article |
| id | doaj.art-b49d1bf707a7458bae71cd21d215fa6d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:41:08Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b49d1bf707a7458bae71cd21d215fa6d2023-11-16T17:00:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243264310.3390/ijms24032643Liposomes for Tumor Targeted Therapy: A ReviewShile Wang0Yanyu Chen1Jiancheng Guo2Qinqin Huang3The Research and Application Center of Precision Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou University, Jingba Road No. 2, Zhengzhou 450014, ChinaThe Research and Application Center of Precision Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou University, Jingba Road No. 2, Zhengzhou 450014, ChinaThe Research and Application Center of Precision Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou University, Jingba Road No. 2, Zhengzhou 450014, ChinaThe Research and Application Center of Precision Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou University, Jingba Road No. 2, Zhengzhou 450014, ChinaLiposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped vesicles consisting of one or more phospholipid bilayers. Compared with traditional drug delivery systems, liposomes exhibit prominent properties that include targeted delivery, high biocompatibility, biodegradability, easy functionalization, low toxicity, improvements in the sustained release of the drug it carries and improved therapeutic indices. In the wake of the rapid development of nanotechnology, the studies of liposome composition have become increasingly extensive. The molecular diversity of liposome composition, which includes long-circulating PEGylated liposomes, ligand-functionalized liposomes, stimuli-responsive liposomes, and advanced cell membrane-coated biomimetic nanocarriers, endows their drug delivery with unique physiological functions. This review describes the composition, types and preparation methods of liposomes, and discusses their targeting strategies in cancer therapy.https://www.mdpi.com/1422-0067/24/3/2643liposomesdrug delivery systemscancer therapy |
| spellingShingle | Shile Wang Yanyu Chen Jiancheng Guo Qinqin Huang Liposomes for Tumor Targeted Therapy: A Review International Journal of Molecular Sciences liposomes drug delivery systems cancer therapy |
| title | Liposomes for Tumor Targeted Therapy: A Review |
| title_full | Liposomes for Tumor Targeted Therapy: A Review |
| title_fullStr | Liposomes for Tumor Targeted Therapy: A Review |
| title_full_unstemmed | Liposomes for Tumor Targeted Therapy: A Review |
| title_short | Liposomes for Tumor Targeted Therapy: A Review |
| title_sort | liposomes for tumor targeted therapy a review |
| topic | liposomes drug delivery systems cancer therapy |
| url | https://www.mdpi.com/1422-0067/24/3/2643 |
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