Microstructural Analysis of Peripheral Lung Tissue through CPMG Inter-Echo Time R2 Dispersion.
Since changes in lung microstructure are important indicators for (early stage) lung pathology, there is a need for quantifiable information of diagnostically challenging cases in a clinical setting, e.g. to evaluate early emphysematous changes in peripheral lung tissue. Considering alveoli as spher...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4636373?pdf=render |
| _version_ | 1818510980034854912 |
|---|---|
| author | Felix T Kurz Thomas Kampf Lukas R Buschle Heinz-Peter Schlemmer Sabine Heiland Martin Bendszus Christian H Ziener |
| author_facet | Felix T Kurz Thomas Kampf Lukas R Buschle Heinz-Peter Schlemmer Sabine Heiland Martin Bendszus Christian H Ziener |
| author_sort | Felix T Kurz |
| collection | DOAJ |
| description | Since changes in lung microstructure are important indicators for (early stage) lung pathology, there is a need for quantifiable information of diagnostically challenging cases in a clinical setting, e.g. to evaluate early emphysematous changes in peripheral lung tissue. Considering alveoli as spherical air-spaces surrounded by a thin film of lung tissue allows deriving an expression for Carr-Purcell-Meiboom-Gill transverse relaxation rates R2 with a dependence on inter-echo time, local air-tissue volume fraction, diffusion coefficient and alveolar diameter, within a weak field approximation. The model relaxation rate exhibits the same hyperbolic tangent dependency as seen in the Luz-Meiboom model and limiting cases agree with Brooks et al. and Jensen et al. In addition, the model is tested against experimental data for passively deflated rat lungs: the resulting mean alveolar radius of RA = 31.46 ± 13.15 μm is very close to the literature value (∼34 μm). Also, modeled radii obtained from relaxometer measurements of ageing hydrogel foam (that mimics peripheral lung tissue) are in good agreement with those obtained from μCT images of the same foam (mean relative error: 0.06 ± 0.01). The model's ability to determine the alveolar radius and/or air volume fraction will be useful in quantifying peripheral lung microstructure. |
| first_indexed | 2024-12-10T23:27:20Z |
| format | Article |
| id | doaj.art-b49e4073ed3a46c392357e5494add3c0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T23:27:20Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b49e4073ed3a46c392357e5494add3c02022-12-22T01:29:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011011e014189410.1371/journal.pone.0141894Microstructural Analysis of Peripheral Lung Tissue through CPMG Inter-Echo Time R2 Dispersion.Felix T KurzThomas KampfLukas R BuschleHeinz-Peter SchlemmerSabine HeilandMartin BendszusChristian H ZienerSince changes in lung microstructure are important indicators for (early stage) lung pathology, there is a need for quantifiable information of diagnostically challenging cases in a clinical setting, e.g. to evaluate early emphysematous changes in peripheral lung tissue. Considering alveoli as spherical air-spaces surrounded by a thin film of lung tissue allows deriving an expression for Carr-Purcell-Meiboom-Gill transverse relaxation rates R2 with a dependence on inter-echo time, local air-tissue volume fraction, diffusion coefficient and alveolar diameter, within a weak field approximation. The model relaxation rate exhibits the same hyperbolic tangent dependency as seen in the Luz-Meiboom model and limiting cases agree with Brooks et al. and Jensen et al. In addition, the model is tested against experimental data for passively deflated rat lungs: the resulting mean alveolar radius of RA = 31.46 ± 13.15 μm is very close to the literature value (∼34 μm). Also, modeled radii obtained from relaxometer measurements of ageing hydrogel foam (that mimics peripheral lung tissue) are in good agreement with those obtained from μCT images of the same foam (mean relative error: 0.06 ± 0.01). The model's ability to determine the alveolar radius and/or air volume fraction will be useful in quantifying peripheral lung microstructure.http://europepmc.org/articles/PMC4636373?pdf=render |
| spellingShingle | Felix T Kurz Thomas Kampf Lukas R Buschle Heinz-Peter Schlemmer Sabine Heiland Martin Bendszus Christian H Ziener Microstructural Analysis of Peripheral Lung Tissue through CPMG Inter-Echo Time R2 Dispersion. PLoS ONE |
| title | Microstructural Analysis of Peripheral Lung Tissue through CPMG Inter-Echo Time R2 Dispersion. |
| title_full | Microstructural Analysis of Peripheral Lung Tissue through CPMG Inter-Echo Time R2 Dispersion. |
| title_fullStr | Microstructural Analysis of Peripheral Lung Tissue through CPMG Inter-Echo Time R2 Dispersion. |
| title_full_unstemmed | Microstructural Analysis of Peripheral Lung Tissue through CPMG Inter-Echo Time R2 Dispersion. |
| title_short | Microstructural Analysis of Peripheral Lung Tissue through CPMG Inter-Echo Time R2 Dispersion. |
| title_sort | microstructural analysis of peripheral lung tissue through cpmg inter echo time r2 dispersion |
| url | http://europepmc.org/articles/PMC4636373?pdf=render |
| work_keys_str_mv | AT felixtkurz microstructuralanalysisofperipherallungtissuethroughcpmginterechotimer2dispersion AT thomaskampf microstructuralanalysisofperipherallungtissuethroughcpmginterechotimer2dispersion AT lukasrbuschle microstructuralanalysisofperipherallungtissuethroughcpmginterechotimer2dispersion AT heinzpeterschlemmer microstructuralanalysisofperipherallungtissuethroughcpmginterechotimer2dispersion AT sabineheiland microstructuralanalysisofperipherallungtissuethroughcpmginterechotimer2dispersion AT martinbendszus microstructuralanalysisofperipherallungtissuethroughcpmginterechotimer2dispersion AT christianhziener microstructuralanalysisofperipherallungtissuethroughcpmginterechotimer2dispersion |