Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives <sup>‡</sup>
The subject of this review article refers to the recent achievements in the investigation of pharmacological activity and supramolecular characteristics of betulinic acid and its diverse derivatives, with special focus on their cytotoxic effect, antitumor activity, and antiviral effect, and mostly c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/19/3546 |
| _version_ | 1818928831362236416 |
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| author | Uladzimir Bildziukevich Zülal Özdemir Zdeněk Wimmer |
| author_facet | Uladzimir Bildziukevich Zülal Özdemir Zdeněk Wimmer |
| author_sort | Uladzimir Bildziukevich |
| collection | DOAJ |
| description | The subject of this review article refers to the recent achievements in the investigation of pharmacological activity and supramolecular characteristics of betulinic acid and its diverse derivatives, with special focus on their cytotoxic effect, antitumor activity, and antiviral effect, and mostly covers a period 2015−2018. Literature sources published earlier are referred to in required coherences or from historical points of view. Relationships between pharmacological activity and supramolecular characteristics are included if such investigation has been done in the original literature sources. A wide practical applicability of betulinic acid and its derivatives demonstrated in the literature sources is also included in this review article. Several literature sources also focused on in silico calculation of physicochemical and ADME parameters of the developed compounds, and on a comparison between the experimental and calculated data. |
| first_indexed | 2024-12-20T03:35:09Z |
| format | Article |
| id | doaj.art-b49efd4fc0fc4f45b789db355690b249 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T03:35:09Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b49efd4fc0fc4f45b789db355690b2492022-12-21T19:54:53ZengMDPI AGMolecules1420-30492019-09-012419354610.3390/molecules24193546molecules24193546Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives <sup>‡</sup>Uladzimir Bildziukevich0Zülal Özdemir1Zdeněk Wimmer2Institute of Experimental Botany of the Czech Academy of Sciences, Isotope Laboratory, Vídeňská 1083, 14220 Prague 4, Czech RepublicInstitute of Experimental Botany of the Czech Academy of Sciences, Isotope Laboratory, Vídeňská 1083, 14220 Prague 4, Czech RepublicInstitute of Experimental Botany of the Czech Academy of Sciences, Isotope Laboratory, Vídeňská 1083, 14220 Prague 4, Czech RepublicThe subject of this review article refers to the recent achievements in the investigation of pharmacological activity and supramolecular characteristics of betulinic acid and its diverse derivatives, with special focus on their cytotoxic effect, antitumor activity, and antiviral effect, and mostly covers a period 2015−2018. Literature sources published earlier are referred to in required coherences or from historical points of view. Relationships between pharmacological activity and supramolecular characteristics are included if such investigation has been done in the original literature sources. A wide practical applicability of betulinic acid and its derivatives demonstrated in the literature sources is also included in this review article. Several literature sources also focused on in silico calculation of physicochemical and ADME parameters of the developed compounds, and on a comparison between the experimental and calculated data.https://www.mdpi.com/1420-3049/24/19/3546betulinic acidstructural modificationsupramolecular self-assemblycytotoxicityantitumor activityantiviral activityphysicochemical parametersadme parameters |
| spellingShingle | Uladzimir Bildziukevich Zülal Özdemir Zdeněk Wimmer Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives <sup>‡</sup> Molecules betulinic acid structural modification supramolecular self-assembly cytotoxicity antitumor activity antiviral activity physicochemical parameters adme parameters |
| title | Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives <sup>‡</sup> |
| title_full | Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives <sup>‡</sup> |
| title_fullStr | Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives <sup>‡</sup> |
| title_full_unstemmed | Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives <sup>‡</sup> |
| title_short | Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives <sup>‡</sup> |
| title_sort | recent achievements in medicinal and supramolecular chemistry of betulinic acid and its derivatives sup ‡ sup |
| topic | betulinic acid structural modification supramolecular self-assembly cytotoxicity antitumor activity antiviral activity physicochemical parameters adme parameters |
| url | https://www.mdpi.com/1420-3049/24/19/3546 |
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