Effect of methylprednisolone use on the rotator cuff in rats: biomechanical and histological study
OBJECTIVE: To evaluate the influence of treatment with different doses of methylprednisolone on the mechanical resistance and possible histological alterations of the rotator cuff tendon in rats.METHODS: Male Wistar rats were divided randomly into four treatment groups: sham, vehicle or 0.6 mg/kg or...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Ortopedia e Traumatologia
2015-06-01
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| Series: | Revista Brasileira de Ortopedia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162015000300260&lng=en&tlng=en |
| _version_ | 1797333032977301504 |
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| author | Gustavo Vinícius Ghellioni Lucas Souto da Silva Anna Paula Piovezan Rafael Olívio Martins |
| author_facet | Gustavo Vinícius Ghellioni Lucas Souto da Silva Anna Paula Piovezan Rafael Olívio Martins |
| author_sort | Gustavo Vinícius Ghellioni |
| collection | DOAJ |
| description | OBJECTIVE: To evaluate the influence of treatment with different doses of methylprednisolone on the mechanical resistance and possible histological alterations of the rotator cuff tendon in rats.METHODS: Male Wistar rats were divided randomly into four treatment groups: sham, vehicle or 0.6 mg/kg or 6.0 mg/kg of methylprednisolone. Changes to mechanical resistance (in N) and histological parameters (fibrillar appearance, presence of collagen, edema and vascular proliferation) of the rotator cuff tendon were evaluated. The analyses were conducted after administration of one treatment (24 h afterwards), two treatments (7 days afterward) or three treatments (14 days afterwards), into the subacromial space.RESULTS: Seven and fourteen days after the treatments were started, it was found that in a dose-dependent manner, methylprednisolone reduced the mechanical resistance of the rotator cuff tendon (p < 0.05 in relation to the vehicle group). Modifications to the histological parameters were observed on the 7th and 14th days after the first infiltration, especially regarding the presence of collagen and vascular proliferation, for the dose of 0.6 mg/kg of methylprednisolone, and also regarding the presence of collagen, edema and vascular proliferation for the dose of 6.0 mg/kg of corticoid.CONCLUSION: The results obtained demonstrated a relationship between methylprednisolone use through infiltration into the subacromial space and reduction of the mechanical resistance of and histological modifications to the rotator cuff tendon in rats. |
| first_indexed | 2024-03-08T07:58:00Z |
| format | Article |
| id | doaj.art-b4a0e88f5a9945b68d51a69ff2ea94e8 |
| institution | Directory Open Access Journal |
| issn | 1982-4378 |
| language | English |
| last_indexed | 2024-03-08T07:58:00Z |
| publishDate | 2015-06-01 |
| publisher | Sociedade Brasileira de Ortopedia e Traumatologia |
| record_format | Article |
| series | Revista Brasileira de Ortopedia |
| spelling | doaj.art-b4a0e88f5a9945b68d51a69ff2ea94e82024-02-02T13:09:59ZengSociedade Brasileira de Ortopedia e TraumatologiaRevista Brasileira de Ortopedia1982-43782015-06-0150326026510.1016/j.rboe.2015.05.002S0102-36162015000300260Effect of methylprednisolone use on the rotator cuff in rats: biomechanical and histological studyGustavo Vinícius GhellioniLucas Souto da SilvaAnna Paula PiovezanRafael Olívio MartinsOBJECTIVE: To evaluate the influence of treatment with different doses of methylprednisolone on the mechanical resistance and possible histological alterations of the rotator cuff tendon in rats.METHODS: Male Wistar rats were divided randomly into four treatment groups: sham, vehicle or 0.6 mg/kg or 6.0 mg/kg of methylprednisolone. Changes to mechanical resistance (in N) and histological parameters (fibrillar appearance, presence of collagen, edema and vascular proliferation) of the rotator cuff tendon were evaluated. The analyses were conducted after administration of one treatment (24 h afterwards), two treatments (7 days afterward) or three treatments (14 days afterwards), into the subacromial space.RESULTS: Seven and fourteen days after the treatments were started, it was found that in a dose-dependent manner, methylprednisolone reduced the mechanical resistance of the rotator cuff tendon (p < 0.05 in relation to the vehicle group). Modifications to the histological parameters were observed on the 7th and 14th days after the first infiltration, especially regarding the presence of collagen and vascular proliferation, for the dose of 0.6 mg/kg of methylprednisolone, and also regarding the presence of collagen, edema and vascular proliferation for the dose of 6.0 mg/kg of corticoid.CONCLUSION: The results obtained demonstrated a relationship between methylprednisolone use through infiltration into the subacromial space and reduction of the mechanical resistance of and histological modifications to the rotator cuff tendon in rats.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162015000300260&lng=en&tlng=enCorticoidesManguito rotadorOrtopedia |
| spellingShingle | Gustavo Vinícius Ghellioni Lucas Souto da Silva Anna Paula Piovezan Rafael Olívio Martins Effect of methylprednisolone use on the rotator cuff in rats: biomechanical and histological study Revista Brasileira de Ortopedia Corticoides Manguito rotador Ortopedia |
| title | Effect of methylprednisolone use on the rotator cuff in rats: biomechanical and histological study |
| title_full | Effect of methylprednisolone use on the rotator cuff in rats: biomechanical and histological study |
| title_fullStr | Effect of methylprednisolone use on the rotator cuff in rats: biomechanical and histological study |
| title_full_unstemmed | Effect of methylprednisolone use on the rotator cuff in rats: biomechanical and histological study |
| title_short | Effect of methylprednisolone use on the rotator cuff in rats: biomechanical and histological study |
| title_sort | effect of methylprednisolone use on the rotator cuff in rats biomechanical and histological study |
| topic | Corticoides Manguito rotador Ortopedia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162015000300260&lng=en&tlng=en |
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