A meta-analysis of the prevalence of toxoplasma gondii igg antibodies in patients with mental disorders
OBJECTIVES AND BACKGROUND Toxoplasma gondii infection has been recently associated with schizophrenia and other psychiatric disorders. The aim of the present study was to evaluate the prevalence of T. gondii infection in psychiatric patients by using meta-analytical methods. MATERIALS AND METH...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Victor Babes University of Medicine and Pharmacy Timisoara
2016-12-01
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| Series: | Research and Clinical Medicine |
| Subjects: | |
| Online Access: | http://www.resclinmed.eu/public/data_files/articles/27/article_27.pdf |
| _version_ | 1819033770975559680 |
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| author | Angela Dragomir1, Tudor Rares Olariu1 |
| author_facet | Angela Dragomir1, Tudor Rares Olariu1 |
| author_sort | Angela Dragomir1, |
| collection | DOAJ |
| description | OBJECTIVES AND BACKGROUND
Toxoplasma gondii infection has been recently
associated with schizophrenia and other psychiatric
disorders. The aim of the present study was to evaluate
the prevalence of T. gondii infection in psychiatric patients
by using meta-analytical methods.
MATERIALS AND METHODS
By systematic research of PUBMED Database, we
identified several articles on this issue. We included casecontrol
studies focused on the seroprevalence of T. gondii
(IgG antibodies) in patients with psychiatric disorders and
healthy controls, published over the past 10 years R3.2.2.
free software for statistical computing and graphics was
used to perform the meta-analysis. Data were pooled
using a random effects model and Mantel-Haenszel
method.
RESULTS
The PUBMED Database showed references to only
seven scientific papers that investigated the prevalence of
T. gondii IgG antibodies in psychiatric patients. Six
hundred seventy three patients and seven hundred
seventy four controls coped with the inclusion criteria
and were used in our analysis. We found a significant
increase of T. gondii IgG antibodies in patients with
schizophrenia and other psychiatric disorders compared
with controls (41.6% vs 24.54%, OR = 2.16, 95% CI =
[1.45-3.21], P = .001).
CONCLUSIONS
An increased seroprevalence of T. gondii IgG
antibodies has been reported in psychiatric patients. Our
study suggests that T. gondii infection may be relevant in
order to determine and understand the complex etiology
of schizophrenia and other psychiatric disorders.
Graphical abstract: Meta-analysis of the
prevalence of T. gondii IgG antibodies in patients
with mental disorders
REFERENCES
1. Hamidinejat H, Ghorbanpoor M, Hosseini H,
Alavi SM, Nabavi L, Jalali MH, Borojeni MP,
Jafari H, Mohammadaligol S. Toxoplasma gondii
infection in first-episode and inpatient individuals
with schizophrenia. Int J Infect Dis.
2010;14:e978-81. doi: 10.1016/j.ijid.2010.05.018.
2. Alvarado-Esquivel C, Carrillo-Oropeza D,
Pacheco-Vega SJ, Hernández-Tinoco J, SalcedoJaquez
M, Sánchez-Anguiano LF, Ortiz-Jurado
MN, Alarcón-Alvarado Y, Liesenfeld O,
Beristain-García I. Toxoplasma gondii exposure
in patients suffering from mental and behavioral
disorders due to psychoactive substance use.
BMC Infect Dis. 2015;15:172. |
| first_indexed | 2024-12-21T07:23:08Z |
| format | Article |
| id | doaj.art-b4a12b2776ad4ede9fd8fe18bb645602 |
| institution | Directory Open Access Journal |
| issn | 2360-1124 2537-5393 |
| language | English |
| last_indexed | 2024-12-21T07:23:08Z |
| publishDate | 2016-12-01 |
| publisher | Victor Babes University of Medicine and Pharmacy Timisoara |
| record_format | Article |
| series | Research and Clinical Medicine |
| spelling | doaj.art-b4a12b2776ad4ede9fd8fe18bb6456022022-12-21T19:11:44ZengVictor Babes University of Medicine and Pharmacy TimisoaraResearch and Clinical Medicine2360-11242537-53932016-12-01ISuppl.156A meta-analysis of the prevalence of toxoplasma gondii igg antibodies in patients with mental disordersAngela Dragomir1, 0Tudor Rares Olariu11Victor Babeș University of Medicine and Pharmacy Timișoara, RomaniaVictor Babeș University of Medicine and Pharmacy Timișoara, RomaniaOBJECTIVES AND BACKGROUND Toxoplasma gondii infection has been recently associated with schizophrenia and other psychiatric disorders. The aim of the present study was to evaluate the prevalence of T. gondii infection in psychiatric patients by using meta-analytical methods. MATERIALS AND METHODS By systematic research of PUBMED Database, we identified several articles on this issue. We included casecontrol studies focused on the seroprevalence of T. gondii (IgG antibodies) in patients with psychiatric disorders and healthy controls, published over the past 10 years R3.2.2. free software for statistical computing and graphics was used to perform the meta-analysis. Data were pooled using a random effects model and Mantel-Haenszel method. RESULTS The PUBMED Database showed references to only seven scientific papers that investigated the prevalence of T. gondii IgG antibodies in psychiatric patients. Six hundred seventy three patients and seven hundred seventy four controls coped with the inclusion criteria and were used in our analysis. We found a significant increase of T. gondii IgG antibodies in patients with schizophrenia and other psychiatric disorders compared with controls (41.6% vs 24.54%, OR = 2.16, 95% CI = [1.45-3.21], P = .001). CONCLUSIONS An increased seroprevalence of T. gondii IgG antibodies has been reported in psychiatric patients. Our study suggests that T. gondii infection may be relevant in order to determine and understand the complex etiology of schizophrenia and other psychiatric disorders. Graphical abstract: Meta-analysis of the prevalence of T. gondii IgG antibodies in patients with mental disorders REFERENCES 1. Hamidinejat H, Ghorbanpoor M, Hosseini H, Alavi SM, Nabavi L, Jalali MH, Borojeni MP, Jafari H, Mohammadaligol S. Toxoplasma gondii infection in first-episode and inpatient individuals with schizophrenia. Int J Infect Dis. 2010;14:e978-81. doi: 10.1016/j.ijid.2010.05.018. 2. Alvarado-Esquivel C, Carrillo-Oropeza D, Pacheco-Vega SJ, Hernández-Tinoco J, SalcedoJaquez M, Sánchez-Anguiano LF, Ortiz-Jurado MN, Alarcón-Alvarado Y, Liesenfeld O, Beristain-García I. Toxoplasma gondii exposure in patients suffering from mental and behavioral disorders due to psychoactive substance use. BMC Infect Dis. 2015;15:172.http://www.resclinmed.eu/public/data_files/articles/27/article_27.pdfToxoplasmosisseroprevalencereviewmetaanalysismental disorders. |
| spellingShingle | Angela Dragomir1, Tudor Rares Olariu1 A meta-analysis of the prevalence of toxoplasma gondii igg antibodies in patients with mental disorders Research and Clinical Medicine Toxoplasmosis seroprevalence review metaanalysis mental disorders. |
| title | A meta-analysis of the prevalence of toxoplasma gondii igg antibodies in patients with mental disorders |
| title_full | A meta-analysis of the prevalence of toxoplasma gondii igg antibodies in patients with mental disorders |
| title_fullStr | A meta-analysis of the prevalence of toxoplasma gondii igg antibodies in patients with mental disorders |
| title_full_unstemmed | A meta-analysis of the prevalence of toxoplasma gondii igg antibodies in patients with mental disorders |
| title_short | A meta-analysis of the prevalence of toxoplasma gondii igg antibodies in patients with mental disorders |
| title_sort | meta analysis of the prevalence of toxoplasma gondii igg antibodies in patients with mental disorders |
| topic | Toxoplasmosis seroprevalence review metaanalysis mental disorders. |
| url | http://www.resclinmed.eu/public/data_files/articles/27/article_27.pdf |
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