An Overview on the Effects of Silibinin on Different MicroRNAs Expression in Cancer
MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of about 60% of human genomes. Silibinin or mixture of silybin A and B is a flavonolignans that constitute 70-80% Silymarin which is considered to be its main effective ingredient. Silibinin revealed antioxidant and anti-infla...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2018-10-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-11714-en.html |
| _version_ | 1797943800185749504 |
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| author | Vahid Akbari Kordkheyli Setareh zarpou Ehsan Nabipur Alireza Tafazoli Abouzar Bagheri |
| author_facet | Vahid Akbari Kordkheyli Setareh zarpou Ehsan Nabipur Alireza Tafazoli Abouzar Bagheri |
| author_sort | Vahid Akbari Kordkheyli |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of about 60% of human genomes. Silibinin or mixture of silybin A and B is a flavonolignans that constitute 70-80% Silymarin which is considered to be its main effective ingredient. Silibinin revealed antioxidant and anti-inflammatory effects by scavenging free radicals, improving antioxidant enzymatic activities, and suppressing NF-кβ activation. One of the recent discoveries about the functions of silibinin, is its ability to change different miRNAs expression, especially in cancer. For instance, silibinin decreases Bcl2 level by inhibiting miR-21 expression in breast cancer cells that leads to apoptosis. Silibinin elevates miR-203 expression in lung cancer cells that causes stimulation of E-cadherin. The component can differentiate mesenchymal phonotype to epithelial. Also, treatment of glioblastoma cancer cells with silibinin diminishes anti-apoptosis factor XIAP by upregulation of miR-7 that causes prevention of autophagia in these cells. Therefore, silibinin could induce apoptosis and differentiation and inhibit proliferation in different cancer cells via regulation of various miRNAs expression. In this review study we aimed to summarize the studies about the effects of silibinin on different miRNAs expression in various types of cancer cells to distinguish the exact mechanism of silibinin anti-cancer effects. |
| first_indexed | 2024-04-10T20:29:56Z |
| format | Article |
| id | doaj.art-b4a3209e77924ea9b98d9895cf1ff00d |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:29:56Z |
| publishDate | 2018-10-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-b4a3209e77924ea9b98d9895cf1ff00d2023-01-25T07:28:50ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792018-10-0128165213229An Overview on the Effects of Silibinin on Different MicroRNAs Expression in CancerVahid Akbari Kordkheyli0Setareh zarpou1Ehsan Nabipur2Alireza Tafazoli3Abouzar Bagheri4 MSc of Medical Biochemistry, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran MSc Student in Medical Biochemistry, Department of Biochemistry-Biophysics and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran MSc of Biochemistry, Department of biochemistry-genetic and plant biology, Faculty of Basic Sciences, Islamic Azad University, Damghan Branch, Damghan, Iran MSc of Mmedical Genetics, Department of Biochemistry, Biophysics and Genetics, Medical Faculty, Mazandaran University of Medical Sciences, Sari, Iran 5 Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 6 Assistant Professor, Department of Clinical Biochemistry-Biophysics and Genetics, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of about 60% of human genomes. Silibinin or mixture of silybin A and B is a flavonolignans that constitute 70-80% Silymarin which is considered to be its main effective ingredient. Silibinin revealed antioxidant and anti-inflammatory effects by scavenging free radicals, improving antioxidant enzymatic activities, and suppressing NF-кβ activation. One of the recent discoveries about the functions of silibinin, is its ability to change different miRNAs expression, especially in cancer. For instance, silibinin decreases Bcl2 level by inhibiting miR-21 expression in breast cancer cells that leads to apoptosis. Silibinin elevates miR-203 expression in lung cancer cells that causes stimulation of E-cadherin. The component can differentiate mesenchymal phonotype to epithelial. Also, treatment of glioblastoma cancer cells with silibinin diminishes anti-apoptosis factor XIAP by upregulation of miR-7 that causes prevention of autophagia in these cells. Therefore, silibinin could induce apoptosis and differentiation and inhibit proliferation in different cancer cells via regulation of various miRNAs expression. In this review study we aimed to summarize the studies about the effects of silibinin on different miRNAs expression in various types of cancer cells to distinguish the exact mechanism of silibinin anti-cancer effects.http://jmums.mazums.ac.ir/article-1-11714-en.htmlsilibininmirnacancer |
| spellingShingle | Vahid Akbari Kordkheyli Setareh zarpou Ehsan Nabipur Alireza Tafazoli Abouzar Bagheri An Overview on the Effects of Silibinin on Different MicroRNAs Expression in Cancer Journal of Mazandaran University of Medical Sciences silibinin mirna cancer |
| title | An Overview on the Effects of Silibinin on Different MicroRNAs Expression in Cancer |
| title_full | An Overview on the Effects of Silibinin on Different MicroRNAs Expression in Cancer |
| title_fullStr | An Overview on the Effects of Silibinin on Different MicroRNAs Expression in Cancer |
| title_full_unstemmed | An Overview on the Effects of Silibinin on Different MicroRNAs Expression in Cancer |
| title_short | An Overview on the Effects of Silibinin on Different MicroRNAs Expression in Cancer |
| title_sort | overview on the effects of silibinin on different micrornas expression in cancer |
| topic | silibinin mirna cancer |
| url | http://jmums.mazums.ac.ir/article-1-11714-en.html |
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