The Association of Intravenous Iron Administered the Day before Total Knee Arthroplasty with Postoperative Anemia and Functional Recovery
<i>Background and Objectives:</i> Total knee arthroplasty (TKA) involves blood loss, increasing the risk of postoperative anemia and delayed functional recovery. Intravenous (IV) iron supplementation limits postoperative anemia; however, the effectiveness of IV iron, administered one day...
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MDPI AG
2023-06-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/7/1212 |
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| author | Ho Jung Jung Min Wook Kang Jong Hwa Lee Joon Kyu Lee Joong Il Kim |
| author_facet | Ho Jung Jung Min Wook Kang Jong Hwa Lee Joon Kyu Lee Joong Il Kim |
| author_sort | Ho Jung Jung |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Total knee arthroplasty (TKA) involves blood loss, increasing the risk of postoperative anemia and delayed functional recovery. Intravenous (IV) iron supplementation limits postoperative anemia; however, the effectiveness of IV iron, administered one day before TKA, on postoperative anemia and functional recovery has scarcely been studied. <i>Materials and Methods:</i> We conducted a retrospective cohort study with propensity score matching using two consecutive groups of patients who underwent TKA using tranexamic acid: the iron group received 500 mg ferric derisomaltose intravenously one day before surgery (n = 46); the non-iron group did not (n = 46). Hemoglobin (Hb) level was determined at postoperative days (PODs) 2, 4, 6, 14, and 30. Ferritin, transferrin saturation (TSAT), and functional iron deficiency anemia (IDA) rate were measured at PODs 2, 4, 6, and 14. Length of hospital stay and transfusion rate were also evaluated. <i>Results:</i> The iron group had higher Hb levels at PODs 6, 14, and 30 and higher ferritin and TSAT at PODs 2, 4, 6, and 14. The functional IDA rate was significantly higher in the non-iron group at PODs 2, 4, 6, and 14. Length of hospital stay was significantly shorter in the iron group; however, the rate of transfusion did not differ between the two groups. <i>Conclusions:</i> IV iron administered one day before TKA was associated with postoperative anemia recovery and length of hospital stay; however, it did not lower the postoperative transfusion rate. |
| first_indexed | 2024-03-11T00:52:03Z |
| format | Article |
| id | doaj.art-b4a35d4e857a4d988fbf7ed7f2ea4893 |
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| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T00:52:03Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-b4a35d4e857a4d988fbf7ed7f2ea48932023-11-18T20:23:24ZengMDPI AGMedicina1010-660X1648-91442023-06-01597121210.3390/medicina59071212The Association of Intravenous Iron Administered the Day before Total Knee Arthroplasty with Postoperative Anemia and Functional RecoveryHo Jung Jung0Min Wook Kang1Jong Hwa Lee2Joon Kyu Lee3Joong Il Kim4Department of Orthopaedic Surgery, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, 77, Sakju-ro, Chuncheon-si 24253, Republic of KoreaDepartment of Orthopaedic Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 1 Singil-ro, Yeongdeungpo-gu, Seoul 07441, Republic of KoreaDepartment of Orthopaedic Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 1 Singil-ro, Yeongdeungpo-gu, Seoul 07441, Republic of KoreaDepartment of Orthopaedic Surgery, Konkuk University Medical Center, Konkuk University School of Medcine, Seoul 05030, Republic of KoreaDepartment of Orthopaedic Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 1 Singil-ro, Yeongdeungpo-gu, Seoul 07441, Republic of Korea<i>Background and Objectives:</i> Total knee arthroplasty (TKA) involves blood loss, increasing the risk of postoperative anemia and delayed functional recovery. Intravenous (IV) iron supplementation limits postoperative anemia; however, the effectiveness of IV iron, administered one day before TKA, on postoperative anemia and functional recovery has scarcely been studied. <i>Materials and Methods:</i> We conducted a retrospective cohort study with propensity score matching using two consecutive groups of patients who underwent TKA using tranexamic acid: the iron group received 500 mg ferric derisomaltose intravenously one day before surgery (n = 46); the non-iron group did not (n = 46). Hemoglobin (Hb) level was determined at postoperative days (PODs) 2, 4, 6, 14, and 30. Ferritin, transferrin saturation (TSAT), and functional iron deficiency anemia (IDA) rate were measured at PODs 2, 4, 6, and 14. Length of hospital stay and transfusion rate were also evaluated. <i>Results:</i> The iron group had higher Hb levels at PODs 6, 14, and 30 and higher ferritin and TSAT at PODs 2, 4, 6, and 14. The functional IDA rate was significantly higher in the non-iron group at PODs 2, 4, 6, and 14. Length of hospital stay was significantly shorter in the iron group; however, the rate of transfusion did not differ between the two groups. <i>Conclusions:</i> IV iron administered one day before TKA was associated with postoperative anemia recovery and length of hospital stay; however, it did not lower the postoperative transfusion rate.https://www.mdpi.com/1648-9144/59/7/1212ironhemoglobinanemia recoverylength of hospital staytotal knee arthroplasty |
| spellingShingle | Ho Jung Jung Min Wook Kang Jong Hwa Lee Joon Kyu Lee Joong Il Kim The Association of Intravenous Iron Administered the Day before Total Knee Arthroplasty with Postoperative Anemia and Functional Recovery Medicina iron hemoglobin anemia recovery length of hospital stay total knee arthroplasty |
| title | The Association of Intravenous Iron Administered the Day before Total Knee Arthroplasty with Postoperative Anemia and Functional Recovery |
| title_full | The Association of Intravenous Iron Administered the Day before Total Knee Arthroplasty with Postoperative Anemia and Functional Recovery |
| title_fullStr | The Association of Intravenous Iron Administered the Day before Total Knee Arthroplasty with Postoperative Anemia and Functional Recovery |
| title_full_unstemmed | The Association of Intravenous Iron Administered the Day before Total Knee Arthroplasty with Postoperative Anemia and Functional Recovery |
| title_short | The Association of Intravenous Iron Administered the Day before Total Knee Arthroplasty with Postoperative Anemia and Functional Recovery |
| title_sort | association of intravenous iron administered the day before total knee arthroplasty with postoperative anemia and functional recovery |
| topic | iron hemoglobin anemia recovery length of hospital stay total knee arthroplasty |
| url | https://www.mdpi.com/1648-9144/59/7/1212 |
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