P478: THE GERMLINE VARIANT GFI1-36N PROMOTES GENETIC INSTABILITY IN LEUKEMIC CELLS AND OPENS NEW THERAPEUTIC APPROACHES FOR ABOUT 15% OF ALL AML PATIENTS

P478: THE GERMLINE VARIANT GFI1-36N PROMOTES GENETIC INSTABILITY IN LEUKEMIC CELLS AND OPENS NEW THERAPEUTIC APPROACHES FOR ABOUT 15% OF ALL AML PATIENTS

Bibliographic Details
Main Authors:	J. Vorwerk, D. Frank, K. Sun, F. Neumannn, M. Heuser, D. Kunadt, W. E. Berdel, J.-H. Mikesch, C. Schliemann, G. Lenz, A. K. Jayavelu, C. Khandanpour
Format:	Article
Language:	English
Published:	Wiley 2022-06-01
Series:	HemaSphere
Online Access:	http://journals.lww.com/10.1097/01.HS9.0000844800.63968.ef

Similar Items

Presence of the GFI1-36N single nucleotide polymorphism enhances the response of MLL-AF9 leukemic cells to CDK4/6 inhibition
by: Jan Vorwerk, et al.
Published: (2022-08-01)

Prevalence of the GFI1-36N SNP in Multiple Myeloma Patients and Its Impact on the Prognosis
by: Cyrus Khandanpour, et al.
Published: (2021-10-01)

GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome (MDS)
by: Botezatu, L, et al.
Published: (2016)

Dose-dependent effect of GFI1 expression in the reconstitution and the differentiation capacity of HSCs
by: Xiaoqing Xie, et al.
Published: (2023-04-01)

P478: MOLECULAR CHARACTERIZATION OF EXTRAMEDULLARY LOCALIZATIONS IN ACUTE MYELOID LEUKEMIA (AML)
by: Giorgia Silvestrini, et al.
Published: (2023-08-01)

Superior efficacy of co-targeting GFI1/KDM1A and BRD4 against AML and post-MPN secondary AML cells
by: Warren Fiskus, et al.
Published: (2021-05-01)

P490: SNORNA-DERIVED RNAS (SDRNAS) ARE IMPORTANT DRIVERS OF LEUKEMOGENESIS AND LEUKEMIC MAINTENANCE IN AML
by: R. Zinz, et al.
Published: (2022-06-01)

Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1.
by: Jennifer Fraszczak, et al.
Published: (2016-01-01)

Multifaceted Actions of GFI1 and GFI1B in Hematopoietic Stem Cell Self-Renewal and Lineage Commitment
by: Hugues Beauchemin, et al.
Published: (2020-10-01)

P478: Streamlining precision medicine: Cancer predisposition germline testing in a large, integrated health system
by: Leslie Manace, et al.
Published: (2024-01-01)

β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells
by: Xin Zhao, et al.
Published: (2020-08-01)

PB2413: SALVAGE THERAPY WITH VENETOCLAX AND A HYPOMETHYLATING AGENT FOR PATIENTS WITH AML RELAPSE AFTER ALLOGENEIC STEM CELL TRANSPLANTATION
by: Inna Shaforostova, et al.
Published: (2023-08-01)

GFI1B variants associated with thrombocytopenia
by: David J. Rabbolini, et al.
Published: (2017-07-01)

Cell-Intrinsic Depletion of AML1-ETO-Positive Pre-Leukemic HSCs By Kras Activating Mutation
by: Di Genua, C, et al.
Published: (2017)

From hypoxia single‐cell gene signatures to HIF targeting of AML leukemic stem cells
by: Thomas Mercher, et al.
Published: (2024-03-01)

Extramedullary Acute Myeloid Leukemia (AML): Leukemic Pleural Effusion, Case Report and Review of the Literature
by: Naveen ePemmaraju, et al.
Published: (2014-06-01)

P442: DDX41 GERMLINE VARIANTS: POPULATION PREVALENCE, SIGNIFICANCE AND LEUKEMIC EVOLUTION
by: Sruthi Cheloor Kovilakam, et al.
Published: (2023-08-01)

LSD1 inhibitors disrupt the GFI1 transcription repressor complex
by: Alba Maiques-Diaz, et al.
Published: (2018-07-01)

Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML
by: Yongping Zhang, et al.
Published: (2023-08-01)

Germline RUNX1 Intragenic Deletion: Implications for Accurate Diagnosis of FPD/AML
by: Nicolas Duployez, et al.
Published: (2019-06-01)

The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants
by: Ana Rio-Machin, et al.
Published: (2020-02-01)

P384: THE ROLE OF THE MANNOSE RECEPTOR C-TYPE 2 (MRC2) IN LEUKEMIC STEM CELL MAINTENANCE IN AML
by: M. Arnone, et al.
Published: (2022-06-01)

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1
by: Charles Vadnais, et al.
Published: (2018-04-01)

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation.
by: Di Genua, C, et al.
Published: (2019)

Proteomic Profiling Identifies Specific Leukemic Stem Cell-Associated Protein Expression Patterns in Pediatric AML Patients
by: Marianne Agerlund Petersen, et al.
Published: (2022-07-01)

Venetoclax combination therapy induces deep AML remission with eradication of leukemic stem cells and remodeling of clonal haematopoiesis
by: Romain Vazquez, et al.
Published: (2021-03-01)

PLG 478 - Kaedah Mengajar Kesusasteraan II
by: PPIP, Pusat Pengajian Ilmu Pendidikan
Published: (1997)

RNA-Guided CRISPR-Cas9 System-Mediated Engineering of Acute Myeloid Leukemia Mutations
by: Oliver Brabetz, et al.
Published: (2017-03-01)

GFI-Net: Global Feature Interaction Network for Monocular Depth Estimation
by: Cong Zhang, et al.
Published: (2023-02-01)

Gfi1 Loss Protects against Two Models of Induced Diabetes
by: Tiziana Napolitano, et al.
Published: (2021-10-01)

Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML
by: Bin Zhang, et al.
Published: (2021-08-01)

A phase I/II feasibility vaccine study by autologous leukemic apoptotic corpse-pulsed dendritic cells for elderly AML patients
by: Patrice Chevallier, et al.
Published: (2021-10-01)

PDP 478 - KAEDAH MENGAJAR KESUSASTERAAN APRIL 1994
by: PPIP, Pusat Pengajian Ilmu Pendidikan
Published: (1994)

PDP 478 - KAEDAH MENGAJAR KESUSASTERAAN APRIL 1993
by: PPIP, Pusat Pengajian Ilmu Pendidikan
Published: (1993)

PDP 478 - KAEDAH MENGAJAR KESUSASTERAAN APRIL 1993.
by: PPIP, Pusat Pengajian Ilmu Pendidikan
Published: (1993)

PDP 478 - KAEDAH MENGAJAR KESUSASTERAAN APRIL 1994.
by: PPIP, Pusat Pengajian Ilmu Pendidikan
Published: (1994)

GFI1 is repressed by p53 and inhibits DNA damage-induced apoptosis.
by: Pei Du, et al.
Published: (2013-01-01)

High GPR56 surface expression correlates with a leukemic stem cell gene signature in CD34‐positive AML
by: Shruti Daga, et al.
Published: (2019-04-01)

Cutaneous Leukemic Infiltrates Successfully Treated With Biomodulatory Therapy in a Rare Case of Therapy-Related High Risk MDS/AML
by: Daniel Heudobler, et al.
Published: (2018-11-01)

COMPARATIVE ANALYSIS OF THE MCDA AND GFI METHODS IN DETERMINING FLOOD-PRONE AREAS IN JATINANGOR DISTRICT, SUMEDANG
by: R. Virtriana, et al.
Published: (2023-09-01)