Impact of nausea/vomiting on EQ-5D-5L utility scores in patients taking iron preparations for heavy menstrual bleeding or anemia
Abstract Background The purpose of this study was to establish an estimating equation to predict the 5-level EQ-5D version (EQ-5D-5L) utility score in patients taking iron preparations for heavy menstrual bleeding (HMB) or anemia and to evaluate whether the presence of nausea or vomiting was a signi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Women's Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12905-023-02652-1 |
| _version_ | 1797556803653861376 |
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| author | Kyoko Ito Yuko Mitobe Ryo Inoue Mikio Momoeda |
| author_facet | Kyoko Ito Yuko Mitobe Ryo Inoue Mikio Momoeda |
| author_sort | Kyoko Ito |
| collection | DOAJ |
| description | Abstract Background The purpose of this study was to establish an estimating equation to predict the 5-level EQ-5D version (EQ-5D-5L) utility score in patients taking iron preparations for heavy menstrual bleeding (HMB) or anemia and to evaluate whether the presence of nausea or vomiting was a significant predictor of EQ-5D-5L-based quality of life. Methods A cross-sectional survey was conducted to collect EQ-5D-5L utility scores and other patient reported outcomes from 385 patients taking iron preparations for HMB or anemia who were selected from the disease patient panel. Using the utility scores as objective variables, explanatory variable candidates were selected considering correlations, multicollinearity, and clinical validity. Predicting models were constructed using regression-based models (linear model, generalized linear model (GLM), Tobit model). Stepwise regression method was applied for selecting statistically significant (p < 0.05) predictors. Goodness-of-fit of models were assessed by mean absolute error and mean squared error (MSE). Results The EQ-5D-5L utility scores (mean ± standard deviation) of 96 patients with nausea/vomiting and 289 patients without nausea/vomiting were 0.67 ± 0.16 and 0.84 ± 0.14, respectively (p < 0.001). The presence of nausea/vomiting was shown to be the most significant factor reducing the utility score in the statistical models using the explanatory variable candidates selected in the study. As the results of the goodness-of-fit test, GLM with the smallest MSE was selected to establish the estimating equation. Conclusion The estimating equation to predict the EQ-5D-5L utility scores in patients taking iron preparations for HMB or anemia was established. The presence of nausea/vomiting was found to be a factor significantly reducing utility scores, with a decrement of the value estimated to be -0.117. Trial registration UMIN000045700 ( http://www.umin.ac.jp/ctr/ ). Registered on October 11, 2021. |
| first_indexed | 2024-03-10T17:07:12Z |
| format | Article |
| id | doaj.art-b4a57e2b8afe43bd8fee369e4cc1fb44 |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-03-10T17:07:12Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-b4a57e2b8afe43bd8fee369e4cc1fb442023-11-20T10:46:11ZengBMCBMC Women's Health1472-68742023-09-0123111110.1186/s12905-023-02652-1Impact of nausea/vomiting on EQ-5D-5L utility scores in patients taking iron preparations for heavy menstrual bleeding or anemiaKyoko Ito0Yuko Mitobe1Ryo Inoue2Mikio Momoeda3Medical Affairs Department, Torii Pharmaceutical Co., Ltd.Medical Affairs Department, Torii Pharmaceutical Co., Ltd.Medical Affairs Department, Torii Pharmaceutical Co., Ltd.Aiiku Maternal and Child Health Center, Aiiku HospitalAbstract Background The purpose of this study was to establish an estimating equation to predict the 5-level EQ-5D version (EQ-5D-5L) utility score in patients taking iron preparations for heavy menstrual bleeding (HMB) or anemia and to evaluate whether the presence of nausea or vomiting was a significant predictor of EQ-5D-5L-based quality of life. Methods A cross-sectional survey was conducted to collect EQ-5D-5L utility scores and other patient reported outcomes from 385 patients taking iron preparations for HMB or anemia who were selected from the disease patient panel. Using the utility scores as objective variables, explanatory variable candidates were selected considering correlations, multicollinearity, and clinical validity. Predicting models were constructed using regression-based models (linear model, generalized linear model (GLM), Tobit model). Stepwise regression method was applied for selecting statistically significant (p < 0.05) predictors. Goodness-of-fit of models were assessed by mean absolute error and mean squared error (MSE). Results The EQ-5D-5L utility scores (mean ± standard deviation) of 96 patients with nausea/vomiting and 289 patients without nausea/vomiting were 0.67 ± 0.16 and 0.84 ± 0.14, respectively (p < 0.001). The presence of nausea/vomiting was shown to be the most significant factor reducing the utility score in the statistical models using the explanatory variable candidates selected in the study. As the results of the goodness-of-fit test, GLM with the smallest MSE was selected to establish the estimating equation. Conclusion The estimating equation to predict the EQ-5D-5L utility scores in patients taking iron preparations for HMB or anemia was established. The presence of nausea/vomiting was found to be a factor significantly reducing utility scores, with a decrement of the value estimated to be -0.117. Trial registration UMIN000045700 ( http://www.umin.ac.jp/ctr/ ). Registered on October 11, 2021.https://doi.org/10.1186/s12905-023-02652-1Iron preparationsNauseaVomitingEQ-5D-5L utility scoresHeavy menstrual bleedingAnemia |
| spellingShingle | Kyoko Ito Yuko Mitobe Ryo Inoue Mikio Momoeda Impact of nausea/vomiting on EQ-5D-5L utility scores in patients taking iron preparations for heavy menstrual bleeding or anemia BMC Women's Health Iron preparations Nausea Vomiting EQ-5D-5L utility scores Heavy menstrual bleeding Anemia |
| title | Impact of nausea/vomiting on EQ-5D-5L utility scores in patients taking iron preparations for heavy menstrual bleeding or anemia |
| title_full | Impact of nausea/vomiting on EQ-5D-5L utility scores in patients taking iron preparations for heavy menstrual bleeding or anemia |
| title_fullStr | Impact of nausea/vomiting on EQ-5D-5L utility scores in patients taking iron preparations for heavy menstrual bleeding or anemia |
| title_full_unstemmed | Impact of nausea/vomiting on EQ-5D-5L utility scores in patients taking iron preparations for heavy menstrual bleeding or anemia |
| title_short | Impact of nausea/vomiting on EQ-5D-5L utility scores in patients taking iron preparations for heavy menstrual bleeding or anemia |
| title_sort | impact of nausea vomiting on eq 5d 5l utility scores in patients taking iron preparations for heavy menstrual bleeding or anemia |
| topic | Iron preparations Nausea Vomiting EQ-5D-5L utility scores Heavy menstrual bleeding Anemia |
| url | https://doi.org/10.1186/s12905-023-02652-1 |
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