RNA Biomarkers: Frontier of Precision Medicine for Cancer
As an essential part of central dogma, RNA delivers genetic and regulatory information and reflects cellular states. Based on high‐throughput sequencing technologies, cumulating data show that various RNA molecules are able to serve as biomarkers for the diagnosis and prognosis of various diseases,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-02-01
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| Series: | Non-Coding RNA |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2311-553X/3/1/9 |
| _version_ | 1818369139231686656 |
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| author | Xiaochen Xi Tianxiao Li Yiming Huang Jiahui Sun Yumin Zhu Yang Yang Zhi John Lu |
| author_facet | Xiaochen Xi Tianxiao Li Yiming Huang Jiahui Sun Yumin Zhu Yang Yang Zhi John Lu |
| author_sort | Xiaochen Xi |
| collection | DOAJ |
| description | As an essential part of central dogma, RNA delivers genetic and regulatory information and reflects cellular states. Based on high‐throughput sequencing technologies, cumulating data show that various RNA molecules are able to serve as biomarkers for the diagnosis and prognosis of various diseases, for instance, cancer. In particular, detectable in various bio‐fluids, such as serum, saliva and urine, extracellular RNAs (exRNAs) are emerging as non‐invasive biomarkers for earlier cancer diagnosis, tumor progression monitor, and prediction of therapy response. In this review, we summarize the latest studies on various types of RNA biomarkers, especially extracellular RNAs, in cancer diagnosis and prognosis, and illustrate several well‐known RNA biomarkers of clinical utility. In addition, we describe and discuss general procedures and issues in investigating exRNA biomarkers, and perspectives on utility of exRNAs in precision medicine. |
| first_indexed | 2024-12-13T23:19:05Z |
| format | Article |
| id | doaj.art-b4a65a2f7d12431fb4a98aaef0a8f9c8 |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-12-13T23:19:05Z |
| publishDate | 2017-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-b4a65a2f7d12431fb4a98aaef0a8f9c82022-12-21T23:27:50ZengMDPI AGNon-Coding RNA2311-553X2017-02-0131910.3390/ncrna3010009ncrna3010009RNA Biomarkers: Frontier of Precision Medicine for CancerXiaochen Xi0Tianxiao Li1Yiming Huang2Jiahui Sun3Yumin Zhu4Yang Yang5Zhi John Lu6MOE Key Laboratory of Bioinformatics, Tsinghua‐Peking Joint Center for Life Sciences, Center for Plant Biology and Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory of Bioinformatics, Tsinghua‐Peking Joint Center for Life Sciences, Center for Plant Biology and Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory of Bioinformatics, Tsinghua‐Peking Joint Center for Life Sciences, Center for Plant Biology and Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory of Bioinformatics, Tsinghua‐Peking Joint Center for Life Sciences, Center for Plant Biology and Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory of Bioinformatics, Tsinghua‐Peking Joint Center for Life Sciences, Center for Plant Biology and Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory of Bioinformatics, Tsinghua‐Peking Joint Center for Life Sciences, Center for Plant Biology and Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory of Bioinformatics, Tsinghua‐Peking Joint Center for Life Sciences, Center for Plant Biology and Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaAs an essential part of central dogma, RNA delivers genetic and regulatory information and reflects cellular states. Based on high‐throughput sequencing technologies, cumulating data show that various RNA molecules are able to serve as biomarkers for the diagnosis and prognosis of various diseases, for instance, cancer. In particular, detectable in various bio‐fluids, such as serum, saliva and urine, extracellular RNAs (exRNAs) are emerging as non‐invasive biomarkers for earlier cancer diagnosis, tumor progression monitor, and prediction of therapy response. In this review, we summarize the latest studies on various types of RNA biomarkers, especially extracellular RNAs, in cancer diagnosis and prognosis, and illustrate several well‐known RNA biomarkers of clinical utility. In addition, we describe and discuss general procedures and issues in investigating exRNA biomarkers, and perspectives on utility of exRNAs in precision medicine.http://www.mdpi.com/2311-553X/3/1/9biomarker exRNA precision medicine cancer |
| spellingShingle | Xiaochen Xi Tianxiao Li Yiming Huang Jiahui Sun Yumin Zhu Yang Yang Zhi John Lu RNA Biomarkers: Frontier of Precision Medicine for Cancer Non-Coding RNA biomarker exRNA precision medicine cancer |
| title | RNA Biomarkers: Frontier of Precision Medicine for Cancer |
| title_full | RNA Biomarkers: Frontier of Precision Medicine for Cancer |
| title_fullStr | RNA Biomarkers: Frontier of Precision Medicine for Cancer |
| title_full_unstemmed | RNA Biomarkers: Frontier of Precision Medicine for Cancer |
| title_short | RNA Biomarkers: Frontier of Precision Medicine for Cancer |
| title_sort | rna biomarkers frontier of precision medicine for cancer |
| topic | biomarker exRNA precision medicine cancer |
| url | http://www.mdpi.com/2311-553X/3/1/9 |
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