Predicting response to combination evofosfamide and immunotherapy under hypoxic conditions in murine models of colon cancer

The goal of this study is to develop a mathematical model that captures the interaction between evofosfamide, immunotherapy, and the hypoxic landscape of the tumor in the treatment of tumors. Recently, we showed that evofosfamide, a hypoxia-activated prodrug, can synergistically improve treatment ou...

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Bibliographic Details
Main Authors: Ernesto A. B. F. Lima, Patrick N. Song, Kirsten Reeves, Benjamin Larimer, Anna G. Sorace, Thomas E. Yankeelov
Format: Article
Language:English
Published: AIMS Press 2023-09-01
Series:Mathematical Biosciences and Engineering
Subjects:
Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2023783?viewType=HTML

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