RRM2 expression in different molecular subtypes of breast cancer and its prognostic significance
Abstract Background Breast cancer is one of the most common types of cancer. Ribonucleotide reductase (RNR) is a heterodimeric tetramer consisting of two Ribonucleoside-diphosphate reductase large subunits (RRM1) and two Ribonucleoside-diphosphate reductase small subunits (RRM2). RRM2 is the buildin...
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13000-021-01174-4 |
| _version_ | 1798034666608918528 |
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| author | Manar Ahmed Abdel-Rahman Mena Mahfouz Hany Onsy Habashy |
| author_facet | Manar Ahmed Abdel-Rahman Mena Mahfouz Hany Onsy Habashy |
| author_sort | Manar Ahmed Abdel-Rahman |
| collection | DOAJ |
| description | Abstract Background Breast cancer is one of the most common types of cancer. Ribonucleotide reductase (RNR) is a heterodimeric tetramer consisting of two Ribonucleoside-diphosphate reductase large subunits (RRM1) and two Ribonucleoside-diphosphate reductase small subunits (RRM2). RRM2 is the building subunit of RNR that is important for synthesis of Deoxynucleoside triphosphate (dNTP) during S phase of cell cycle during DNA replication. RRM2 is associated with poor prognosis in lung and colorectal cancer. In breast cancer, increased RRM2 protein level is strongly correlated with large tumour size, positive lymph node and relapse. In this study, we aimed to study expression of RRM2 in breast cancer and to correlate it with different clinicopathological parameters in Egyptian women. Material and methods This study was performed by investigating RRM2 protein expression in breast cancer and correlating the results with other clinicopathological variables using immunohistochemistry and tissue microarrays. Results About 77% of cases were RRM2 positive. High Ki67 was observed in cases with high RRM2 score. The majority of non-luminal cases expressed RRM2, however this was statistically insignificant. In ER positive group, RRM2 expression was associated with shorter disease free survival with borderline significance. Conclusion RRM2 protein expression can help in evaluating outcome of breast cancer patients and could be a potential therapeutic target. |
| first_indexed | 2024-04-11T20:47:27Z |
| format | Article |
| id | doaj.art-b4a92475ed9a48bdb5644cb515997539 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-04-11T20:47:27Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-b4a92475ed9a48bdb5644cb5159975392022-12-22T04:03:58ZengBMCDiagnostic Pathology1746-15962022-01-011711810.1186/s13000-021-01174-4RRM2 expression in different molecular subtypes of breast cancer and its prognostic significanceManar Ahmed Abdel-Rahman0Mena Mahfouz1Hany Onsy Habashy2Department of Pathology, Faculty of Medicine, Mansoura UniversityDepartment of Pathology, Faculty of Medicine, Mansoura UniversityDepartment of Pathology, Faculty of Medicine, Mansoura UniversityAbstract Background Breast cancer is one of the most common types of cancer. Ribonucleotide reductase (RNR) is a heterodimeric tetramer consisting of two Ribonucleoside-diphosphate reductase large subunits (RRM1) and two Ribonucleoside-diphosphate reductase small subunits (RRM2). RRM2 is the building subunit of RNR that is important for synthesis of Deoxynucleoside triphosphate (dNTP) during S phase of cell cycle during DNA replication. RRM2 is associated with poor prognosis in lung and colorectal cancer. In breast cancer, increased RRM2 protein level is strongly correlated with large tumour size, positive lymph node and relapse. In this study, we aimed to study expression of RRM2 in breast cancer and to correlate it with different clinicopathological parameters in Egyptian women. Material and methods This study was performed by investigating RRM2 protein expression in breast cancer and correlating the results with other clinicopathological variables using immunohistochemistry and tissue microarrays. Results About 77% of cases were RRM2 positive. High Ki67 was observed in cases with high RRM2 score. The majority of non-luminal cases expressed RRM2, however this was statistically insignificant. In ER positive group, RRM2 expression was associated with shorter disease free survival with borderline significance. Conclusion RRM2 protein expression can help in evaluating outcome of breast cancer patients and could be a potential therapeutic target.https://doi.org/10.1186/s13000-021-01174-4Breast cancerRRM2ExpressionPrognosis |
| spellingShingle | Manar Ahmed Abdel-Rahman Mena Mahfouz Hany Onsy Habashy RRM2 expression in different molecular subtypes of breast cancer and its prognostic significance Diagnostic Pathology Breast cancer RRM2 Expression Prognosis |
| title | RRM2 expression in different molecular subtypes of breast cancer and its prognostic significance |
| title_full | RRM2 expression in different molecular subtypes of breast cancer and its prognostic significance |
| title_fullStr | RRM2 expression in different molecular subtypes of breast cancer and its prognostic significance |
| title_full_unstemmed | RRM2 expression in different molecular subtypes of breast cancer and its prognostic significance |
| title_short | RRM2 expression in different molecular subtypes of breast cancer and its prognostic significance |
| title_sort | rrm2 expression in different molecular subtypes of breast cancer and its prognostic significance |
| topic | Breast cancer RRM2 Expression Prognosis |
| url | https://doi.org/10.1186/s13000-021-01174-4 |
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