Resveratrol and piperine enhance radiosensitivity of tumor cells
The use of ionizing radiation (IR) is essential for treating manyhuman cancers. However, radioresistance markedly impairsthe efficacy of tumor radiotherapy. IR enhances the productionof reactive oxygen species (ROS) in a variety of cells which aredeterminant components in the induction of apoptosis....
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| Format: | Article |
| Language: | English |
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Korean Society for Biochemistry and Molecular Biology
2012-04-01
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| Series: | BMB Reports |
| Subjects: | |
| Online Access: | http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS00JTVEMTIwNDI2MTkxMF8lMjgyNDItMjQ2JTI5Qk1CXzExLTIzNS5wZGY= |
| _version_ | 1818030678492577792 |
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| author | Jean Kyoung Tak Jun Ho Lee Jeen-Woo Park |
| author_facet | Jean Kyoung Tak Jun Ho Lee Jeen-Woo Park |
| author_sort | Jean Kyoung Tak |
| collection | DOAJ |
| description | The use of ionizing radiation (IR) is essential for treating manyhuman cancers. However, radioresistance markedly impairsthe efficacy of tumor radiotherapy. IR enhances the productionof reactive oxygen species (ROS) in a variety of cells which aredeterminant components in the induction of apoptosis. Muchinterest has developed to augment the effect of radiation in tumorsby combining it with radiosensitizers to improve the therapeuticratio. In the current study, the radiosensitizing effectsof resveratrol and piperine on cancer cells were evaluated.Cancer cell lines treated with these natural products exhibitedsignificantly augmented IR-induced apoptosis and loss of mitochondrialmembrane potential, presumably through enhancedROS generation. Applying natural products as sensitizersfor IR-induced apoptotic cell death offers a promisingtherapeutic approach to treat cancer. [BMB reports 2012;45(4): 242-246] |
| first_indexed | 2024-12-10T05:39:24Z |
| format | Article |
| id | doaj.art-b4a93c6053da409d8b4cc10ff0982378 |
| institution | Directory Open Access Journal |
| issn | 1976-6696 1976-670X |
| language | English |
| last_indexed | 2024-12-10T05:39:24Z |
| publishDate | 2012-04-01 |
| publisher | Korean Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | BMB Reports |
| spelling | doaj.art-b4a93c6053da409d8b4cc10ff09823782022-12-22T02:00:20ZengKorean Society for Biochemistry and Molecular BiologyBMB Reports1976-66961976-670X2012-04-01454242246http://dx.doi.org/10.5483/BMBRep.2012.45.4.242Resveratrol and piperine enhance radiosensitivity of tumor cellsJean Kyoung TakJun Ho LeeJeen-Woo ParkThe use of ionizing radiation (IR) is essential for treating manyhuman cancers. However, radioresistance markedly impairsthe efficacy of tumor radiotherapy. IR enhances the productionof reactive oxygen species (ROS) in a variety of cells which aredeterminant components in the induction of apoptosis. Muchinterest has developed to augment the effect of radiation in tumorsby combining it with radiosensitizers to improve the therapeuticratio. In the current study, the radiosensitizing effectsof resveratrol and piperine on cancer cells were evaluated.Cancer cell lines treated with these natural products exhibitedsignificantly augmented IR-induced apoptosis and loss of mitochondrialmembrane potential, presumably through enhancedROS generation. Applying natural products as sensitizersfor IR-induced apoptotic cell death offers a promisingtherapeutic approach to treat cancer. [BMB reports 2012;45(4): 242-246]http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS00JTVEMTIwNDI2MTkxMF8lMjgyNDItMjQ2JTI5Qk1CXzExLTIzNS5wZGY=ApoptosisIonizing radiationNatural productsRadiosensitizerRedox status |
| spellingShingle | Jean Kyoung Tak Jun Ho Lee Jeen-Woo Park Resveratrol and piperine enhance radiosensitivity of tumor cells BMB Reports Apoptosis Ionizing radiation Natural products Radiosensitizer Redox status |
| title | Resveratrol and piperine enhance radiosensitivity of tumor cells |
| title_full | Resveratrol and piperine enhance radiosensitivity of tumor cells |
| title_fullStr | Resveratrol and piperine enhance radiosensitivity of tumor cells |
| title_full_unstemmed | Resveratrol and piperine enhance radiosensitivity of tumor cells |
| title_short | Resveratrol and piperine enhance radiosensitivity of tumor cells |
| title_sort | resveratrol and piperine enhance radiosensitivity of tumor cells |
| topic | Apoptosis Ionizing radiation Natural products Radiosensitizer Redox status |
| url | http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS00JTVEMTIwNDI2MTkxMF8lMjgyNDItMjQ2JTI5Qk1CXzExLTIzNS5wZGY= |
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