Effects of Gut Microbiota on Host Adaptive Immunity Under Immune Homeostasis and Tumor Pathology State
Gut microbiota stimulate and shape the body’s adaptive immune response through bacterial components and its active metabolites, which orchestrates the formation and maintenance of the body’s immune homeostasis. In addition, the imbalances in microbiota-adaptive immunity contribute to the development...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.844335/full |
| _version_ | 1819320419442753536 |
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| author | Yanan Li Zixuan Ye Jianguo Zhu Shuguang Fang Lijuan Meng Chen Zhou |
| author_facet | Yanan Li Zixuan Ye Jianguo Zhu Shuguang Fang Lijuan Meng Chen Zhou |
| author_sort | Yanan Li |
| collection | DOAJ |
| description | Gut microbiota stimulate and shape the body’s adaptive immune response through bacterial components and its active metabolites, which orchestrates the formation and maintenance of the body’s immune homeostasis. In addition, the imbalances in microbiota-adaptive immunity contribute to the development of tumor and the antitumor efficiency of a series of antitumor therapies at the preclinical and clinical levels. Regardless of significant results, the regulation of gut microbiota on adaptive immunity in immune homeostasis and tumors needs a more thorough understanding. Herein, we highlighted the comprehensive knowledge, status, and limitations in the mechanism of microbiome interaction with adaptive immunity and put forward the prospect of how to translate these insights in inhibiting tumor progression and enhancing the efficacy of antitumor interventions. |
| first_indexed | 2024-12-24T11:19:17Z |
| format | Article |
| id | doaj.art-b4ac7ecc57d34175ac1eff1a9d72b0a6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-24T11:19:17Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b4ac7ecc57d34175ac1eff1a9d72b0a62022-12-21T16:58:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-03-011310.3389/fimmu.2022.844335844335Effects of Gut Microbiota on Host Adaptive Immunity Under Immune Homeostasis and Tumor Pathology StateYanan Li0Zixuan Ye1Jianguo Zhu2Shuguang Fang3Lijuan Meng4Chen Zhou5School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, ChinaSchool of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, ChinaResearch and Development Department，Wecare-bio Probiotics Co., Ltd., Suzhou, ChinaResearch and Development Department，Wecare-bio Probiotics Co., Ltd., Suzhou, ChinaDepartment of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaGut microbiota stimulate and shape the body’s adaptive immune response through bacterial components and its active metabolites, which orchestrates the formation and maintenance of the body’s immune homeostasis. In addition, the imbalances in microbiota-adaptive immunity contribute to the development of tumor and the antitumor efficiency of a series of antitumor therapies at the preclinical and clinical levels. Regardless of significant results, the regulation of gut microbiota on adaptive immunity in immune homeostasis and tumors needs a more thorough understanding. Herein, we highlighted the comprehensive knowledge, status, and limitations in the mechanism of microbiome interaction with adaptive immunity and put forward the prospect of how to translate these insights in inhibiting tumor progression and enhancing the efficacy of antitumor interventions.https://www.frontiersin.org/articles/10.3389/fimmu.2022.844335/fullmicrobiotaadaptive immunityhomeostasistumorimmunotherapy |
| spellingShingle | Yanan Li Zixuan Ye Jianguo Zhu Shuguang Fang Lijuan Meng Chen Zhou Effects of Gut Microbiota on Host Adaptive Immunity Under Immune Homeostasis and Tumor Pathology State Frontiers in Immunology microbiota adaptive immunity homeostasis tumor immunotherapy |
| title | Effects of Gut Microbiota on Host Adaptive Immunity Under Immune Homeostasis and Tumor Pathology State |
| title_full | Effects of Gut Microbiota on Host Adaptive Immunity Under Immune Homeostasis and Tumor Pathology State |
| title_fullStr | Effects of Gut Microbiota on Host Adaptive Immunity Under Immune Homeostasis and Tumor Pathology State |
| title_full_unstemmed | Effects of Gut Microbiota on Host Adaptive Immunity Under Immune Homeostasis and Tumor Pathology State |
| title_short | Effects of Gut Microbiota on Host Adaptive Immunity Under Immune Homeostasis and Tumor Pathology State |
| title_sort | effects of gut microbiota on host adaptive immunity under immune homeostasis and tumor pathology state |
| topic | microbiota adaptive immunity homeostasis tumor immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.844335/full |
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