Brazilian Populations of <i>Aedes aegypti</i> Resistant to Pyriproxyfen Exhibit Lower Susceptibility to Infection with Zika Virus
Zika virus (ZIKV) infection has caused devastating consequences in Brazil as infections were associated with neurological complications in neonates. <i>Aedes aegypti</i> is the primary vector of ZIKV, and the evolution of insecticide resistance (IR) in this species can compromise control...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/10/2198 |
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| author | Kauara Brito Campos Abdullah A. Alomar Bradley H. Eastmond Marcos Takashi Obara Barry W. Alto |
| author_facet | Kauara Brito Campos Abdullah A. Alomar Bradley H. Eastmond Marcos Takashi Obara Barry W. Alto |
| author_sort | Kauara Brito Campos |
| collection | DOAJ |
| description | Zika virus (ZIKV) infection has caused devastating consequences in Brazil as infections were associated with neurological complications in neonates. <i>Aedes aegypti</i> is the primary vector of ZIKV, and the evolution of insecticide resistance (IR) in this species can compromise control efforts. Although relative levels of phenotypic IR in mosquitoes can change considerably over time, its influence on vector competence for arboviruses is unclear. Pyriproxyfen (PPF)-resistant populations of <i>Ae. aegypti</i> were collected from five municipalities located in Northeast of Brazil, which demonstrated different resistance levels; low (Serrinha, Brumado), moderate (Juazeiro do Norte, Itabuna), and high (Quixadá). Experimental per os infection using ZIKV were performed with individuals from these populations and with an insecticide susceptible strain (Rockefeller) to determine their relative vector competence for ZIKV. Although all populations were competent to transmit ZIKV, mosquitoes derived from populations with moderate to high levels of IR exhibited similar or lower susceptibility to ZIKV infection than those from populations with low IR or the susceptible strain. These observations suggest an association between IR and arbovirus infection, which may be attributable to genetic hitchhiking. The use of PPF to control Brazilian <i>Ae. aegypti</i> may be associated with an indirect benefit of reduced susceptibility to infection, but no changes in disseminated infection and transmission of ZIKV among PPF-resistant phenotypes. |
| first_indexed | 2024-03-09T19:23:12Z |
| format | Article |
| id | doaj.art-b4ac9126ac104da4ba268fa219b6122f |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T19:23:12Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-b4ac9126ac104da4ba268fa219b6122f2023-11-24T03:09:12ZengMDPI AGViruses1999-49152022-10-011410219810.3390/v14102198Brazilian Populations of <i>Aedes aegypti</i> Resistant to Pyriproxyfen Exhibit Lower Susceptibility to Infection with Zika VirusKauara Brito Campos0Abdullah A. Alomar1Bradley H. Eastmond2Marcos Takashi Obara3Barry W. Alto4Entomology and Nematology Department, Florida Medical Entomology Laboratory, Institute of Food and Agricultural Sciences, University of Florida, 200 9th SE, Vero Beach, FL 32962, USAEntomology and Nematology Department, Florida Medical Entomology Laboratory, Institute of Food and Agricultural Sciences, University of Florida, 200 9th SE, Vero Beach, FL 32962, USAEntomology and Nematology Department, Florida Medical Entomology Laboratory, Institute of Food and Agricultural Sciences, University of Florida, 200 9th SE, Vero Beach, FL 32962, USALaboratório de Parasitologia Médica e Biologia de Vetores, Faculdade de Medicina, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília 70910-900, BrazilEntomology and Nematology Department, Florida Medical Entomology Laboratory, Institute of Food and Agricultural Sciences, University of Florida, 200 9th SE, Vero Beach, FL 32962, USAZika virus (ZIKV) infection has caused devastating consequences in Brazil as infections were associated with neurological complications in neonates. <i>Aedes aegypti</i> is the primary vector of ZIKV, and the evolution of insecticide resistance (IR) in this species can compromise control efforts. Although relative levels of phenotypic IR in mosquitoes can change considerably over time, its influence on vector competence for arboviruses is unclear. Pyriproxyfen (PPF)-resistant populations of <i>Ae. aegypti</i> were collected from five municipalities located in Northeast of Brazil, which demonstrated different resistance levels; low (Serrinha, Brumado), moderate (Juazeiro do Norte, Itabuna), and high (Quixadá). Experimental per os infection using ZIKV were performed with individuals from these populations and with an insecticide susceptible strain (Rockefeller) to determine their relative vector competence for ZIKV. Although all populations were competent to transmit ZIKV, mosquitoes derived from populations with moderate to high levels of IR exhibited similar or lower susceptibility to ZIKV infection than those from populations with low IR or the susceptible strain. These observations suggest an association between IR and arbovirus infection, which may be attributable to genetic hitchhiking. The use of PPF to control Brazilian <i>Ae. aegypti</i> may be associated with an indirect benefit of reduced susceptibility to infection, but no changes in disseminated infection and transmission of ZIKV among PPF-resistant phenotypes.https://www.mdpi.com/1999-4915/14/10/2198Zika virus<i>Aedes aegypti</i>pyriproxyfenper os infectioninsecticide resistanceviral titer |
| spellingShingle | Kauara Brito Campos Abdullah A. Alomar Bradley H. Eastmond Marcos Takashi Obara Barry W. Alto Brazilian Populations of <i>Aedes aegypti</i> Resistant to Pyriproxyfen Exhibit Lower Susceptibility to Infection with Zika Virus Viruses Zika virus <i>Aedes aegypti</i> pyriproxyfen per os infection insecticide resistance viral titer |
| title | Brazilian Populations of <i>Aedes aegypti</i> Resistant to Pyriproxyfen Exhibit Lower Susceptibility to Infection with Zika Virus |
| title_full | Brazilian Populations of <i>Aedes aegypti</i> Resistant to Pyriproxyfen Exhibit Lower Susceptibility to Infection with Zika Virus |
| title_fullStr | Brazilian Populations of <i>Aedes aegypti</i> Resistant to Pyriproxyfen Exhibit Lower Susceptibility to Infection with Zika Virus |
| title_full_unstemmed | Brazilian Populations of <i>Aedes aegypti</i> Resistant to Pyriproxyfen Exhibit Lower Susceptibility to Infection with Zika Virus |
| title_short | Brazilian Populations of <i>Aedes aegypti</i> Resistant to Pyriproxyfen Exhibit Lower Susceptibility to Infection with Zika Virus |
| title_sort | brazilian populations of i aedes aegypti i resistant to pyriproxyfen exhibit lower susceptibility to infection with zika virus |
| topic | Zika virus <i>Aedes aegypti</i> pyriproxyfen per os infection insecticide resistance viral titer |
| url | https://www.mdpi.com/1999-4915/14/10/2198 |
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