Xie Zhuo Tiao Zhi formula ameliorates chronic alcohol-induced liver injury in mice
This study aimed to evaluate the protective role and potential mechanisms of Xie Zhuo Tiao Zhi decoction (XZTZ) on alcohol-associated liver disease (ALD). XZTZ significantly alleviated alcohol-induced liver dysfunction, based on histological examinations and biochemical parameters after 4-week admin...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-04-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1363131/full |
| _version_ | 1797213549373685760 |
|---|---|
| author | Kaixin Chang Rui Guo Wenbo Hu Xuezhu Wang Feiwei Cao Jiannan Qiu Jiaomei Li Qiang Han Zhongyan Du Xiaobing Dou Songtao Li |
| author_facet | Kaixin Chang Rui Guo Wenbo Hu Xuezhu Wang Feiwei Cao Jiannan Qiu Jiaomei Li Qiang Han Zhongyan Du Xiaobing Dou Songtao Li |
| author_sort | Kaixin Chang |
| collection | DOAJ |
| description | This study aimed to evaluate the protective role and potential mechanisms of Xie Zhuo Tiao Zhi decoction (XZTZ) on alcohol-associated liver disease (ALD). XZTZ significantly alleviated alcohol-induced liver dysfunction, based on histological examinations and biochemical parameters after 4-week administration. Mechanically, alcohol-stimulated hepatic oxidative stress was ameliorated by XZTZ, accompanied by the improvement of Nrf2/Keap1 expression and alcohol-activated phosphorylation of pro-inflammatory transcription factors, including JNK, P38, P65, and IκBα, were rescued by XZTZ. In conclusion, XZTZ demonstrates potential in alleviating alcohol-induced liver injury, oxidative stress, and inflammation possibly through modulation of Nrf2/Keap1 and MAPKs/NF-κB signaling pathways, suggesting its potential as a therapeutic option for patients with alcoholic liver disease. |
| first_indexed | 2024-04-24T11:00:03Z |
| format | Article |
| id | doaj.art-b4accc3fb7784199bb6d8d46c8f12a5f |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-24T11:00:03Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-b4accc3fb7784199bb6d8d46c8f12a5f2024-04-12T04:19:16ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-04-011510.3389/fphar.2024.13631311363131Xie Zhuo Tiao Zhi formula ameliorates chronic alcohol-induced liver injury in miceKaixin Chang0Rui Guo1Wenbo Hu2Xuezhu Wang3Feiwei Cao4Jiannan Qiu5Jiaomei Li6Qiang Han7Zhongyan Du8Xiaobing Dou9Songtao Li10School of Life Science, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Public Health, Zhejiang Chinese Medical University, Hangzhou, ChinaThe First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Public Health, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Public Health, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Life Science, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Public Health, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Public Health, Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory of Blood-Stasis-Toxin Syndrome of Zhejiang Province, Zhejiang Engineering Research Center for ‘Preventive Treatment’ Smart Health of Traditional Chinese Medicine, School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Life Science, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Public Health, Zhejiang Chinese Medical University, Hangzhou, ChinaThis study aimed to evaluate the protective role and potential mechanisms of Xie Zhuo Tiao Zhi decoction (XZTZ) on alcohol-associated liver disease (ALD). XZTZ significantly alleviated alcohol-induced liver dysfunction, based on histological examinations and biochemical parameters after 4-week administration. Mechanically, alcohol-stimulated hepatic oxidative stress was ameliorated by XZTZ, accompanied by the improvement of Nrf2/Keap1 expression and alcohol-activated phosphorylation of pro-inflammatory transcription factors, including JNK, P38, P65, and IκBα, were rescued by XZTZ. In conclusion, XZTZ demonstrates potential in alleviating alcohol-induced liver injury, oxidative stress, and inflammation possibly through modulation of Nrf2/Keap1 and MAPKs/NF-κB signaling pathways, suggesting its potential as a therapeutic option for patients with alcoholic liver disease.https://www.frontiersin.org/articles/10.3389/fphar.2024.1363131/fullXie Zhuo Tiao Zhi decoctionalcohol-associated liver diseaseliver injuryoxidative stressliver inflammation |
| spellingShingle | Kaixin Chang Rui Guo Wenbo Hu Xuezhu Wang Feiwei Cao Jiannan Qiu Jiaomei Li Qiang Han Zhongyan Du Xiaobing Dou Songtao Li Xie Zhuo Tiao Zhi formula ameliorates chronic alcohol-induced liver injury in mice Frontiers in Pharmacology Xie Zhuo Tiao Zhi decoction alcohol-associated liver disease liver injury oxidative stress liver inflammation |
| title | Xie Zhuo Tiao Zhi formula ameliorates chronic alcohol-induced liver injury in mice |
| title_full | Xie Zhuo Tiao Zhi formula ameliorates chronic alcohol-induced liver injury in mice |
| title_fullStr | Xie Zhuo Tiao Zhi formula ameliorates chronic alcohol-induced liver injury in mice |
| title_full_unstemmed | Xie Zhuo Tiao Zhi formula ameliorates chronic alcohol-induced liver injury in mice |
| title_short | Xie Zhuo Tiao Zhi formula ameliorates chronic alcohol-induced liver injury in mice |
| title_sort | xie zhuo tiao zhi formula ameliorates chronic alcohol induced liver injury in mice |
| topic | Xie Zhuo Tiao Zhi decoction alcohol-associated liver disease liver injury oxidative stress liver inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1363131/full |
| work_keys_str_mv | AT kaixinchang xiezhuotiaozhiformulaameliorateschronicalcoholinducedliverinjuryinmice AT ruiguo xiezhuotiaozhiformulaameliorateschronicalcoholinducedliverinjuryinmice AT wenbohu xiezhuotiaozhiformulaameliorateschronicalcoholinducedliverinjuryinmice AT xuezhuwang xiezhuotiaozhiformulaameliorateschronicalcoholinducedliverinjuryinmice AT feiweicao xiezhuotiaozhiformulaameliorateschronicalcoholinducedliverinjuryinmice AT jiannanqiu xiezhuotiaozhiformulaameliorateschronicalcoholinducedliverinjuryinmice AT jiaomeili xiezhuotiaozhiformulaameliorateschronicalcoholinducedliverinjuryinmice AT qianghan xiezhuotiaozhiformulaameliorateschronicalcoholinducedliverinjuryinmice AT zhongyandu xiezhuotiaozhiformulaameliorateschronicalcoholinducedliverinjuryinmice AT xiaobingdou xiezhuotiaozhiformulaameliorateschronicalcoholinducedliverinjuryinmice AT songtaoli xiezhuotiaozhiformulaameliorateschronicalcoholinducedliverinjuryinmice |