Recent Advances on DNAzyme-Based Biosensors for Detection of Uranyl
Nuclear facilities are widely used in fields such as national defense, industry, scientific research, and medicine, which play a huge role in military and civilian use. However, in the process of widespread application of nuclear technology, uranium and its compounds with high carcinogenic and biolo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.882250/full |
| _version_ | 1818275100455075840 |
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| author | Yunlong Bai Lechang Xu Huining Chai Lei Zhou Guoping Jiang Guangyao Zhang |
| author_facet | Yunlong Bai Lechang Xu Huining Chai Lei Zhou Guoping Jiang Guangyao Zhang |
| author_sort | Yunlong Bai |
| collection | DOAJ |
| description | Nuclear facilities are widely used in fields such as national defense, industry, scientific research, and medicine, which play a huge role in military and civilian use. However, in the process of widespread application of nuclear technology, uranium and its compounds with high carcinogenic and biologically toxic cause a lot of environmental problems, such as pollutions of water, atmosphere, soil, or ecosystem. Bioensors with sensitivity and specificity for the detection of uranium are highly demand. Nucleic acid enzymes (DNAzyme) with merits of high sensitivity and selectivity for targets as excellent molecular recognition elements are commonly used for uranium sensor development. In this perspective review, we summarize DNAzyme-based biosensors for the quantitative detection of uranyl ions by integrating with diverse signal outputting strategies, such as fluorescent, colorimetry, surface-enhanced Raman scattering, and electrochemistry. Different design methods, limit of detection, and practical applications are fully discussed. Finally, the challenges, potential solutions, and future prospects of such DNAzyme-based sensors are also presented. |
| first_indexed | 2024-12-12T22:24:23Z |
| format | Article |
| id | doaj.art-b4ad3a6be7d94505b6fc693b247d8029 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-12T22:24:23Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-b4ad3a6be7d94505b6fc693b247d80292022-12-22T00:09:49ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-04-011010.3389/fchem.2022.882250882250Recent Advances on DNAzyme-Based Biosensors for Detection of UranylYunlong Bai0Lechang Xu1Huining Chai2Lei Zhou3Guoping Jiang4Guangyao Zhang5Beijing Research Institute of Chemical Engineering and Metallurgy, China National Nuclear Corporation, Beijing, ChinaBeijing Research Institute of Chemical Engineering and Metallurgy, China National Nuclear Corporation, Beijing, ChinaSchool of Environmental and Municipal Engineering, Qingdao University of Technology, Qingdao, ChinaBeijing Research Institute of Chemical Engineering and Metallurgy, China National Nuclear Corporation, Beijing, ChinaBeijing Research Institute of Chemical Engineering and Metallurgy, China National Nuclear Corporation, Beijing, ChinaIntelligent Wearable Engineering Research Center of Qingdao, Research Center for Intelligent and Wearable Technology, College of Textiles and Clothing, State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, ChinaNuclear facilities are widely used in fields such as national defense, industry, scientific research, and medicine, which play a huge role in military and civilian use. However, in the process of widespread application of nuclear technology, uranium and its compounds with high carcinogenic and biologically toxic cause a lot of environmental problems, such as pollutions of water, atmosphere, soil, or ecosystem. Bioensors with sensitivity and specificity for the detection of uranium are highly demand. Nucleic acid enzymes (DNAzyme) with merits of high sensitivity and selectivity for targets as excellent molecular recognition elements are commonly used for uranium sensor development. In this perspective review, we summarize DNAzyme-based biosensors for the quantitative detection of uranyl ions by integrating with diverse signal outputting strategies, such as fluorescent, colorimetry, surface-enhanced Raman scattering, and electrochemistry. Different design methods, limit of detection, and practical applications are fully discussed. Finally, the challenges, potential solutions, and future prospects of such DNAzyme-based sensors are also presented.https://www.frontiersin.org/articles/10.3389/fchem.2022.882250/fulluranyl sensorDNAzymeenvironmental monitoringdetectionspectrumelectrochemistry |
| spellingShingle | Yunlong Bai Lechang Xu Huining Chai Lei Zhou Guoping Jiang Guangyao Zhang Recent Advances on DNAzyme-Based Biosensors for Detection of Uranyl Frontiers in Chemistry uranyl sensor DNAzyme environmental monitoring detection spectrum electrochemistry |
| title | Recent Advances on DNAzyme-Based Biosensors for Detection of Uranyl |
| title_full | Recent Advances on DNAzyme-Based Biosensors for Detection of Uranyl |
| title_fullStr | Recent Advances on DNAzyme-Based Biosensors for Detection of Uranyl |
| title_full_unstemmed | Recent Advances on DNAzyme-Based Biosensors for Detection of Uranyl |
| title_short | Recent Advances on DNAzyme-Based Biosensors for Detection of Uranyl |
| title_sort | recent advances on dnazyme based biosensors for detection of uranyl |
| topic | uranyl sensor DNAzyme environmental monitoring detection spectrum electrochemistry |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.882250/full |
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