Epithelial-to-Pericyte Transition in Cancer
During epithelial-to-mesenchymal transition (EMT), cells lose epithelial characteristics and acquire mesenchymal properties. These two processes are genetically separable and governed by distinct transcriptional programs, rendering the EMT outputs highly heterogeneous. Our recent study shows that th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/9/7/77 |
| _version_ | 1797766737883561984 |
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| author | Jianrong Lu Anitha K. Shenoy |
| author_facet | Jianrong Lu Anitha K. Shenoy |
| author_sort | Jianrong Lu |
| collection | DOAJ |
| description | During epithelial-to-mesenchymal transition (EMT), cells lose epithelial characteristics and acquire mesenchymal properties. These two processes are genetically separable and governed by distinct transcriptional programs, rendering the EMT outputs highly heterogeneous. Our recent study shows that the mesenchymal products generated by EMT often express multiple pericyte markers, associate with and stabilize blood vessels to fuel tumor growth, thus phenotypically and functionally resembling pericytes. Therefore, some EMT events represent epithelial-to-pericyte transition (EPT). The serum response factor (SRF) plays key roles in both EMT and differentiation of pericytes, and may inherently confer the pericyte attributes on EMT cancer cells. By impacting their intratumoral location and cell surface receptor expression, EPT may enable cancer cells to receive and respond to angiocrine factors produced by the vascular niche, and develop therapy resistance. |
| first_indexed | 2024-03-12T20:28:34Z |
| format | Article |
| id | doaj.art-b4adacd659f8466684cb9033dcff7a7f |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T20:28:34Z |
| publishDate | 2017-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b4adacd659f8466684cb9033dcff7a7f2023-08-02T00:16:49ZengMDPI AGCancers2072-66942017-07-01977710.3390/cancers9070077cancers9070077Epithelial-to-Pericyte Transition in CancerJianrong Lu0Anitha K. Shenoy1Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610-3633, USADepartment of Pharmaceutics and Biomedical Sciences, California Health Sciences University, Clovis, CA 93612, USADuring epithelial-to-mesenchymal transition (EMT), cells lose epithelial characteristics and acquire mesenchymal properties. These two processes are genetically separable and governed by distinct transcriptional programs, rendering the EMT outputs highly heterogeneous. Our recent study shows that the mesenchymal products generated by EMT often express multiple pericyte markers, associate with and stabilize blood vessels to fuel tumor growth, thus phenotypically and functionally resembling pericytes. Therefore, some EMT events represent epithelial-to-pericyte transition (EPT). The serum response factor (SRF) plays key roles in both EMT and differentiation of pericytes, and may inherently confer the pericyte attributes on EMT cancer cells. By impacting their intratumoral location and cell surface receptor expression, EPT may enable cancer cells to receive and respond to angiocrine factors produced by the vascular niche, and develop therapy resistance.https://www.mdpi.com/2072-6694/9/7/77EMTEPTSRFmyocardin-related transcription factors (MRTF)pericyteresistancevascular nicheangiocrine factors |
| spellingShingle | Jianrong Lu Anitha K. Shenoy Epithelial-to-Pericyte Transition in Cancer Cancers EMT EPT SRF myocardin-related transcription factors (MRTF) pericyte resistance vascular niche angiocrine factors |
| title | Epithelial-to-Pericyte Transition in Cancer |
| title_full | Epithelial-to-Pericyte Transition in Cancer |
| title_fullStr | Epithelial-to-Pericyte Transition in Cancer |
| title_full_unstemmed | Epithelial-to-Pericyte Transition in Cancer |
| title_short | Epithelial-to-Pericyte Transition in Cancer |
| title_sort | epithelial to pericyte transition in cancer |
| topic | EMT EPT SRF myocardin-related transcription factors (MRTF) pericyte resistance vascular niche angiocrine factors |
| url | https://www.mdpi.com/2072-6694/9/7/77 |
| work_keys_str_mv | AT jianronglu epithelialtopericytetransitionincancer AT anithakshenoy epithelialtopericytetransitionincancer |