Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps.

Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps.

A key function of the Vpu protein of HIV-1 is the targeting of newly-synthesized CD4 for proteasomal degradation. This function has been proposed to occur by a mechanism that is fundamentally distinct from the cellular ER-associated degradation (ERAD) pathway. However, using a combination of genetic...

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Bibliographic Details
Main Authors: Javier G Magadán, F Javier Pérez-Victoria, Rachid Sougrat, Yihong Ye, Klaus Strebel, Juan S Bonifacino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20442859/?tool=EBI

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