Aspartic Acid Stabilized Iron Oxide Nanoparticles for Biomedical Applications
Aspartic acid stabilized iron oxide nanoparticles (A-IONPs) with globular shape and narrow size distribution were prepared by the co-precipitation method in aqueous medium. A quantum-mechanical approach to aspartic acid optimized structure displayed negative charged sites, relatively high dipole mom...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/7/1151 |
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| author | Mihaela Răcuciu Lucian Barbu-Tudoran Simona Oancea Olga Drăghici Cezarina Morosanu Marian Grigoras Florin Brînză Dorina E. Creangă |
| author_facet | Mihaela Răcuciu Lucian Barbu-Tudoran Simona Oancea Olga Drăghici Cezarina Morosanu Marian Grigoras Florin Brînză Dorina E. Creangă |
| author_sort | Mihaela Răcuciu |
| collection | DOAJ |
| description | Aspartic acid stabilized iron oxide nanoparticles (A-IONPs) with globular shape and narrow size distribution were prepared by the co-precipitation method in aqueous medium. A quantum-mechanical approach to aspartic acid optimized structure displayed negative charged sites, relatively high dipole moment, and hydrophilicity, which recommended it for interaction with iron cations and surrounding water electrical dipoles. A-IONPs were characterized by TEM, XRD, ATR-FTIR, EDS, DSC, TG, DLS, NTA, and VSM techniques. Theoretical study carried out by applying Hartree-Fock and density functional algorithms suggested that some aspartic acid properties related to the interaction can develop with nanoparticles and water molecules. The results of experimental investigation showed that the mean value of particle physical diameters was 9.17 ± 2.2 nm according to TEM image analysis, the crystallite size was about 8.9 nm according to XRD data, while the magnetic diameter was about 8.8 nm, as was determined from VSM data interpretation with Langevin’s theory. The A-IONP suspension was characterized by zeta-potential of about −11.7 mV, while the NTA investigation revealed a hydrodynamic diameter of 153.9 nm. These results recommend the A-IONP suspension for biomedical applications. |
| first_indexed | 2024-03-09T11:35:16Z |
| format | Article |
| id | doaj.art-b4b07d44f4f247698c0ae7bb4cabc8b9 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T11:35:16Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-b4b07d44f4f247698c0ae7bb4cabc8b92023-11-30T23:45:12ZengMDPI AGNanomaterials2079-49912022-03-01127115110.3390/nano12071151Aspartic Acid Stabilized Iron Oxide Nanoparticles for Biomedical ApplicationsMihaela Răcuciu0Lucian Barbu-Tudoran1Simona Oancea2Olga Drăghici3Cezarina Morosanu4Marian Grigoras5Florin Brînză6Dorina E. Creangă7Environmental Sciences and Physics Department, Faculty of Sciences, “Lucian Blaga” University of Sibiu, Dr. I. Ratiu Str., no. 5-7, 550012 Sibiu, RomaniaElectron Microscopy Integrated Laboratory, National Institute for R&D of Isotopic and Molecular Technologies, Donat Str., no. 67-103, 400293 Cluj-Napoca, RomaniaAgricultural Sciences and Food Engineering Department, Lucian Blaga University of Sibiu, Dr. I. Ratiu Str., no. 7-9, 550012 Sibiu, RomaniaAgricultural Sciences and Food Engineering Department, Lucian Blaga University of Sibiu, Dr. I. Ratiu Str., no. 7-9, 550012 Sibiu, RomaniaBiophysics and Medical Physics Laboratory, Faculty of Physics, “Alexandru Ioan Cuza” University, 11, Carol I Blvd., 700506 Iasi, RomaniaNational Institute of Research and Development for Technical Physics, 47, Mangeron Blvd., 700050 Iasi, RomaniaBiophysics and Medical Physics Laboratory, Faculty of Physics, “Alexandru Ioan Cuza” University, 11, Carol I Blvd., 700506 Iasi, RomaniaBiophysics and Medical Physics Laboratory, Faculty of Physics, “Alexandru Ioan Cuza” University, 11, Carol I Blvd., 700506 Iasi, RomaniaAspartic acid stabilized iron oxide nanoparticles (A-IONPs) with globular shape and narrow size distribution were prepared by the co-precipitation method in aqueous medium. A quantum-mechanical approach to aspartic acid optimized structure displayed negative charged sites, relatively high dipole moment, and hydrophilicity, which recommended it for interaction with iron cations and surrounding water electrical dipoles. A-IONPs were characterized by TEM, XRD, ATR-FTIR, EDS, DSC, TG, DLS, NTA, and VSM techniques. Theoretical study carried out by applying Hartree-Fock and density functional algorithms suggested that some aspartic acid properties related to the interaction can develop with nanoparticles and water molecules. The results of experimental investigation showed that the mean value of particle physical diameters was 9.17 ± 2.2 nm according to TEM image analysis, the crystallite size was about 8.9 nm according to XRD data, while the magnetic diameter was about 8.8 nm, as was determined from VSM data interpretation with Langevin’s theory. The A-IONP suspension was characterized by zeta-potential of about −11.7 mV, while the NTA investigation revealed a hydrodynamic diameter of 153.9 nm. These results recommend the A-IONP suspension for biomedical applications.https://www.mdpi.com/2079-4991/12/7/1151iron oxide nanoparticlesnanoparticles synthesisL-aspartic acidnanoparticles sizephysical and chemical characterization |
| spellingShingle | Mihaela Răcuciu Lucian Barbu-Tudoran Simona Oancea Olga Drăghici Cezarina Morosanu Marian Grigoras Florin Brînză Dorina E. Creangă Aspartic Acid Stabilized Iron Oxide Nanoparticles for Biomedical Applications Nanomaterials iron oxide nanoparticles nanoparticles synthesis L-aspartic acid nanoparticles size physical and chemical characterization |
| title | Aspartic Acid Stabilized Iron Oxide Nanoparticles for Biomedical Applications |
| title_full | Aspartic Acid Stabilized Iron Oxide Nanoparticles for Biomedical Applications |
| title_fullStr | Aspartic Acid Stabilized Iron Oxide Nanoparticles for Biomedical Applications |
| title_full_unstemmed | Aspartic Acid Stabilized Iron Oxide Nanoparticles for Biomedical Applications |
| title_short | Aspartic Acid Stabilized Iron Oxide Nanoparticles for Biomedical Applications |
| title_sort | aspartic acid stabilized iron oxide nanoparticles for biomedical applications |
| topic | iron oxide nanoparticles nanoparticles synthesis L-aspartic acid nanoparticles size physical and chemical characterization |
| url | https://www.mdpi.com/2079-4991/12/7/1151 |
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