An autopsy case of cerebral arterial thrombosis after vaccination with ChAdOx1 nCOV-19

We present a fatal case of cerebral arterial thrombosis after corona virus disease 19 (COVID-19) vaccination with ChAdOx1 nCOV-19. The deceased was a 63-year-old woman with no relevant medical history. She presented symptoms of nausea, fatigue, and headache immediately after vaccination. Ten days af...

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Main Authors: Hyeji Yang, Jaeyoon Ha, Hyun Wook Kang
Format: Article
Language:English
Published: Institute for Medical Science, Jeju National University 2022-08-01
Series:Journal of Medicine and Life Science
Subjects:
Online Access:http://www.e-jmls.org/upload/pdf/jmls-2022-19-2-74.pdf
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author Hyeji Yang
Jaeyoon Ha
Hyun Wook Kang
author_facet Hyeji Yang
Jaeyoon Ha
Hyun Wook Kang
author_sort Hyeji Yang
collection DOAJ
description We present a fatal case of cerebral arterial thrombosis after corona virus disease 19 (COVID-19) vaccination with ChAdOx1 nCOV-19. The deceased was a 63-year-old woman with no relevant medical history. She presented symptoms of nausea, fatigue, and headache immediately after vaccination. Ten days after vaccination, she suddenly started vomiting and developed high blood pressure. The patient eventually died 23 days after vaccination. Autopsy findings showed that the cerebral arteries and internal carotid arteries were fully enlarged and were compacted with thrombi. The brain stem showed ischemic necrosis, and extravasation from this necrotic lesion led to focal subarachnoid hemorrhage around the brain stem where large blood clots still remained. No aneurysms or atherosclerotic changes were found in these arteries. We note the following three facts. Firstly, all symptoms occurred immediately after vaccination; secondly, the main cause of death was consistent with known side effects of the vaccine; and lastly, the mechanism of thrombus formation in this case goes beyond the general category of thrombogenesis known so far. While the authors know that this case does not fall into known categories of vaccine side effects, we presenting this case to demonstrate that a comprehensive review of various possibilities related to vaccine side effects is needed to establish a COVID-19 defense system.
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spelling doaj.art-b4b0e3de5c584e49b6b193b4ba90bb3b2023-08-31T05:23:38ZengInstitute for Medical Science, Jeju National UniversityJournal of Medicine and Life Science2671-49222022-08-01192747710.22730/jmls.2022.19.2.74494An autopsy case of cerebral arterial thrombosis after vaccination with ChAdOx1 nCOV-19Hyeji Yang0Jaeyoon Ha1Hyun Wook Kang2 Department of Forensic Medicine, Jeju National University College of Medicine, Jeju, Republic of Korea Department of Forensic Medicine, Jeju National University College of Medicine, Jeju, Republic of Korea Department of Forensic Medicine, Jeju National University College of Medicine, Jeju, Republic of KoreaWe present a fatal case of cerebral arterial thrombosis after corona virus disease 19 (COVID-19) vaccination with ChAdOx1 nCOV-19. The deceased was a 63-year-old woman with no relevant medical history. She presented symptoms of nausea, fatigue, and headache immediately after vaccination. Ten days after vaccination, she suddenly started vomiting and developed high blood pressure. The patient eventually died 23 days after vaccination. Autopsy findings showed that the cerebral arteries and internal carotid arteries were fully enlarged and were compacted with thrombi. The brain stem showed ischemic necrosis, and extravasation from this necrotic lesion led to focal subarachnoid hemorrhage around the brain stem where large blood clots still remained. No aneurysms or atherosclerotic changes were found in these arteries. We note the following three facts. Firstly, all symptoms occurred immediately after vaccination; secondly, the main cause of death was consistent with known side effects of the vaccine; and lastly, the mechanism of thrombus formation in this case goes beyond the general category of thrombogenesis known so far. While the authors know that this case does not fall into known categories of vaccine side effects, we presenting this case to demonstrate that a comprehensive review of various possibilities related to vaccine side effects is needed to establish a COVID-19 defense system.http://www.e-jmls.org/upload/pdf/jmls-2022-19-2-74.pdfcovid-19chadox1 ncov-19cerebral infarction
spellingShingle Hyeji Yang
Jaeyoon Ha
Hyun Wook Kang
An autopsy case of cerebral arterial thrombosis after vaccination with ChAdOx1 nCOV-19
Journal of Medicine and Life Science
covid-19
chadox1 ncov-19
cerebral infarction
title An autopsy case of cerebral arterial thrombosis after vaccination with ChAdOx1 nCOV-19
title_full An autopsy case of cerebral arterial thrombosis after vaccination with ChAdOx1 nCOV-19
title_fullStr An autopsy case of cerebral arterial thrombosis after vaccination with ChAdOx1 nCOV-19
title_full_unstemmed An autopsy case of cerebral arterial thrombosis after vaccination with ChAdOx1 nCOV-19
title_short An autopsy case of cerebral arterial thrombosis after vaccination with ChAdOx1 nCOV-19
title_sort autopsy case of cerebral arterial thrombosis after vaccination with chadox1 ncov 19
topic covid-19
chadox1 ncov-19
cerebral infarction
url http://www.e-jmls.org/upload/pdf/jmls-2022-19-2-74.pdf
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