Cortical circuitry mediating interareal touch signal amplification
Summary: Sensory cortical areas are organized into topographic maps representing the sensory epithelium. Interareal projections typically connect topographically matched subregions across areas. Because matched subregions process the same stimulus, their interaction is central to many computations....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723015449 |
| _version_ | 1827592950068019200 |
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| author | Lauren Ryan Andrew Sun-Yan Maya Laughton Simon Peron |
| author_facet | Lauren Ryan Andrew Sun-Yan Maya Laughton Simon Peron |
| author_sort | Lauren Ryan |
| collection | DOAJ |
| description | Summary: Sensory cortical areas are organized into topographic maps representing the sensory epithelium. Interareal projections typically connect topographically matched subregions across areas. Because matched subregions process the same stimulus, their interaction is central to many computations. Here, we ask how topographically matched subregions of primary and secondary vibrissal somatosensory cortices (vS1 and vS2) interact during active touch. Volumetric calcium imaging in mice palpating an object with two whiskers revealed a sparse population of highly responsive, broadly tuned touch neurons especially pronounced in layer 2 of both areas. These rare neurons exhibited elevated synchrony and carried most touch-evoked activity in both directions. Lesioning the subregion of either area responding to the spared whiskers degraded touch responses in the unlesioned area, with whisker-specific vS1 lesions degrading whisker-specific vS2 touch responses. Thus, a sparse population of broadly tuned touch neurons dominates vS1-vS2 communication in both directions, and topographically matched vS1 and vS2 subregions recurrently amplify whisker touch activity. |
| first_indexed | 2024-03-09T02:02:06Z |
| format | Article |
| id | doaj.art-b4b359c4027b40db8ef3c62f9922aec3 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-09T02:02:06Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-b4b359c4027b40db8ef3c62f9922aec32023-12-08T04:45:19ZengElsevierCell Reports2211-12472023-12-014212113532Cortical circuitry mediating interareal touch signal amplificationLauren Ryan0Andrew Sun-Yan1Maya Laughton2Simon Peron3Center for Neural Science, New York University, 4 Washington Place, Rm. 621, New York, NY 10003, USACenter for Neural Science, New York University, 4 Washington Place, Rm. 621, New York, NY 10003, USACenter for Neural Science, New York University, 4 Washington Place, Rm. 621, New York, NY 10003, USACenter for Neural Science, New York University, 4 Washington Place, Rm. 621, New York, NY 10003, USA; Corresponding authorSummary: Sensory cortical areas are organized into topographic maps representing the sensory epithelium. Interareal projections typically connect topographically matched subregions across areas. Because matched subregions process the same stimulus, their interaction is central to many computations. Here, we ask how topographically matched subregions of primary and secondary vibrissal somatosensory cortices (vS1 and vS2) interact during active touch. Volumetric calcium imaging in mice palpating an object with two whiskers revealed a sparse population of highly responsive, broadly tuned touch neurons especially pronounced in layer 2 of both areas. These rare neurons exhibited elevated synchrony and carried most touch-evoked activity in both directions. Lesioning the subregion of either area responding to the spared whiskers degraded touch responses in the unlesioned area, with whisker-specific vS1 lesions degrading whisker-specific vS2 touch responses. Thus, a sparse population of broadly tuned touch neurons dominates vS1-vS2 communication in both directions, and topographically matched vS1 and vS2 subregions recurrently amplify whisker touch activity.http://www.sciencedirect.com/science/article/pii/S2211124723015449CP: NeuroscienceCP: Cell biology |
| spellingShingle | Lauren Ryan Andrew Sun-Yan Maya Laughton Simon Peron Cortical circuitry mediating interareal touch signal amplification Cell Reports CP: Neuroscience CP: Cell biology |
| title | Cortical circuitry mediating interareal touch signal amplification |
| title_full | Cortical circuitry mediating interareal touch signal amplification |
| title_fullStr | Cortical circuitry mediating interareal touch signal amplification |
| title_full_unstemmed | Cortical circuitry mediating interareal touch signal amplification |
| title_short | Cortical circuitry mediating interareal touch signal amplification |
| title_sort | cortical circuitry mediating interareal touch signal amplification |
| topic | CP: Neuroscience CP: Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723015449 |
| work_keys_str_mv | AT laurenryan corticalcircuitrymediatinginterarealtouchsignalamplification AT andrewsunyan corticalcircuitrymediatinginterarealtouchsignalamplification AT mayalaughton corticalcircuitrymediatinginterarealtouchsignalamplification AT simonperon corticalcircuitrymediatinginterarealtouchsignalamplification |