Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1

Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1

The initiation of DNA replication requires two protein kinases: cyclin-dependent kinase (Cdk) and Cdc7. Although S phase Cdk activity has been intensively studied, relatively little is known about how Cdc7 regulates progression through S phase. We have used a Cdc7 inhibitor, PHA-767491, to dissect t...

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Bibliographic Details
Main Authors: Wei Theng Poh, Gaganmeet Singh Chadha, Peter J. Gillespie, Philipp Kaldis, J. Julian Blow
Format: Article
Language:English
Published: The Royal Society 2014-01-01
Series:Open Biology
Subjects:
cdc7
xenopus
dna replication
pp1
pha-767491
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.130138

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