The molecular basis of the genesis of basal tone in internal anal sphincter
The molecular basis of the basal tone generated by internal anal sphincters (IAS) is largely unknown. Here, the authors show that the tone arises from a global rise in intracellular Ca2+ in smooth muscle cells via a Ryanodine receptor-TMEM16A-L-type Ca2+channel-MLC kinase pathway, suggesting a poten...
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Bibliographic Details
| Main Authors: |
Cheng-Hai Zhang,
Pei Wang,
Dong-Hai Liu,
Cai-Ping Chen,
Wei Zhao,
Xin Chen,
Chen Chen,
Wei-Qi He,
Yan-Ning Qiao,
Tao Tao,
Jie Sun,
Ya-Jing Peng,
Ping Lu,
Kaizhi Zheng,
Siobhan M. Craige,
Lawrence M. Lifshitz,
John F. Keaney Jr,
Kevin E. Fogarty,
Ronghua ZhuGe,
Min-Sheng Zhu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2016-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms11358
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