Recent advance of herbal medicines in cancer- a molecular approach
Bioactive compounds are crucial for an extensive range of therapeutic uses, and some exhibit anticancer activity. Scientists advocate that phytochemicals modulate autophagy and apoptosis, involved in the underlying pathobiology of cancer development and regulation. The pharmacological aiming of the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023008915 |
| _version_ | 1811161710927544320 |
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| author | Mohammad Ali Shahid Ud Din Wani Md Salahuddin Manjula S.N. Mruthunjaya K Tathagata Dey Mohammed Iqbal Zargar Jagadeesh Singh |
| author_facet | Mohammad Ali Shahid Ud Din Wani Md Salahuddin Manjula S.N. Mruthunjaya K Tathagata Dey Mohammed Iqbal Zargar Jagadeesh Singh |
| author_sort | Mohammad Ali |
| collection | DOAJ |
| description | Bioactive compounds are crucial for an extensive range of therapeutic uses, and some exhibit anticancer activity. Scientists advocate that phytochemicals modulate autophagy and apoptosis, involved in the underlying pathobiology of cancer development and regulation. The pharmacological aiming of the autophagy-apoptosis signaling pathway using phytocompounds hence offers an auspicious method that is complementary to conventional cancer chemotherapy. The current review aims to explore the molecular level of the autophagic-apoptotic pathway to know its implication in the pathobiology of cancer and explore the essential cellular process as a druggable anticancer target and therapeutic emergence of naturally derived phytocompound-based anticancer agents. The data in the review were collected from scientific databases such as Google search, Web of Science, PubMed, Scopus, Medline, and Clinical Trials. With a broad outlook, we investigated their cutting-edge scientifically revealed and/or searched pharmacologic effects, a novel mechanism of action, and molecular signaling pathway of phytochemicals in cancer therapy. In this review, the evidence is focused on molecular pharmacology, specifically caspase, Nrf2, NF-kB, autophagic-apoptotic pathway, and several mechanisms to understand their role in cancer biology. |
| first_indexed | 2024-04-10T06:19:49Z |
| format | Article |
| id | doaj.art-b4b7d84db32e4149abe895d26b3c1521 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-10T06:19:49Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-b4b7d84db32e4149abe895d26b3c15212023-03-02T05:02:28ZengElsevierHeliyon2405-84402023-02-0192e13684Recent advance of herbal medicines in cancer- a molecular approachMohammad Ali0Shahid Ud Din Wani1Md Salahuddin2Manjula S.N.3Mruthunjaya K4Tathagata Dey5Mohammed Iqbal Zargar6Jagadeesh Singh7Department of Pharmacy Practice, East Point College of Pharmacy, Bangalore, 560049, IndiaDepartment of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Srinagar, 190006, India; Corresponding author.Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy, Bangalore, 560027, IndiaDepartment of Pharmacology, JSS College of Pharmacy Mysuru, JSS Academy of Higher Education and Research, Mysuru, 570004, IndiaDepartment of Pharmacognosy, JSS College of Pharmacy Mysuru, JSS Academy of Higher Education and Research, Mysuru, 570004, IndiaDepartment of Pharmaceutical Chemistry, East Point College of Pharmacy, Bangalore, 560049, IndiaDepartment of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Srinagar, 190006, IndiaDepartment of Pharmacognosy, East Point College of Pharmacy, Bangalore, 560049, IndiaBioactive compounds are crucial for an extensive range of therapeutic uses, and some exhibit anticancer activity. Scientists advocate that phytochemicals modulate autophagy and apoptosis, involved in the underlying pathobiology of cancer development and regulation. The pharmacological aiming of the autophagy-apoptosis signaling pathway using phytocompounds hence offers an auspicious method that is complementary to conventional cancer chemotherapy. The current review aims to explore the molecular level of the autophagic-apoptotic pathway to know its implication in the pathobiology of cancer and explore the essential cellular process as a druggable anticancer target and therapeutic emergence of naturally derived phytocompound-based anticancer agents. The data in the review were collected from scientific databases such as Google search, Web of Science, PubMed, Scopus, Medline, and Clinical Trials. With a broad outlook, we investigated their cutting-edge scientifically revealed and/or searched pharmacologic effects, a novel mechanism of action, and molecular signaling pathway of phytochemicals in cancer therapy. In this review, the evidence is focused on molecular pharmacology, specifically caspase, Nrf2, NF-kB, autophagic-apoptotic pathway, and several mechanisms to understand their role in cancer biology.http://www.sciencedirect.com/science/article/pii/S2405844023008915AnticancerPhytochemicalsPharmacologyAutophagyApoptosisMolecular mechanism |
| spellingShingle | Mohammad Ali Shahid Ud Din Wani Md Salahuddin Manjula S.N. Mruthunjaya K Tathagata Dey Mohammed Iqbal Zargar Jagadeesh Singh Recent advance of herbal medicines in cancer- a molecular approach Heliyon Anticancer Phytochemicals Pharmacology Autophagy Apoptosis Molecular mechanism |
| title | Recent advance of herbal medicines in cancer- a molecular approach |
| title_full | Recent advance of herbal medicines in cancer- a molecular approach |
| title_fullStr | Recent advance of herbal medicines in cancer- a molecular approach |
| title_full_unstemmed | Recent advance of herbal medicines in cancer- a molecular approach |
| title_short | Recent advance of herbal medicines in cancer- a molecular approach |
| title_sort | recent advance of herbal medicines in cancer a molecular approach |
| topic | Anticancer Phytochemicals Pharmacology Autophagy Apoptosis Molecular mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023008915 |
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