Comparative Analysis of Myocardial Protection with HTK Solution and Hypothermic Hyperkalemic Blood Solution in the Correction of Acyanogenic Congenital Cardiopathies - A Randomized Study
Abstract Objective: The goal of the present study was to compare the myocardial protection obtained with histidine-tryptophan-ketoglutarate (HTK) cardioplegic solution (Custodiol®) and with intermittent hypothermic blood solution. Methods: Two homogenous groups of 25 children with acyanotic congen...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Cirurgia Cardiovascular
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| Series: | Brazilian Journal of Cardiovascular Surgery |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382019000300271&lng=en&tlng=en |
| _version_ | 1828347098980941824 |
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| author | Acrisio Sales Valente Gustavo Porto Lustosa Lia Alves Martins Mota Adriano Lima Fernando Antônio de Mesquita Aloísio Gondim Fábio Alércio Rodrigues Ronald Guedes Pompeu Klébia Castelo Branco |
| author_facet | Acrisio Sales Valente Gustavo Porto Lustosa Lia Alves Martins Mota Adriano Lima Fernando Antônio de Mesquita Aloísio Gondim Fábio Alércio Rodrigues Ronald Guedes Pompeu Klébia Castelo Branco |
| author_sort | Acrisio Sales Valente |
| collection | DOAJ |
| description | Abstract Objective: The goal of the present study was to compare the myocardial protection obtained with histidine-tryptophan-ketoglutarate (HTK) cardioplegic solution (Custodiol®) and with intermittent hypothermic blood solution. Methods: Two homogenous groups of 25 children with acyanotic congenital heart disease who underwent total correction with mean aortic clamping time of 60 minutes were evaluated in this randomized study. Troponin and creatine kinase-MB curves, vasoactive-inotropic score, and left ventricular function were obtained by echocardiogram in each group. The values were correlated and presented through graphs and tables after adequate statistical treatment. Results: It was observed that values of all the studied variables varied over time, but there was no difference between the groups. Conclusion: We conclude that in patients with acyanotic congenital cardiopathies submitted to total surgical correction, mean aortic clamping time around one hour, and cardiopulmonary bypass with moderate hypothermia, the HTK crystalloid cardioplegic solution offers the same myocardial protection as the cold-blood hyperkalemic cardioplegic solution analyzed, according to the variables considered in our study model. |
| first_indexed | 2024-04-14T00:35:15Z |
| format | Article |
| id | doaj.art-b4b868413ff445f18120ed29abbfd7c5 |
| institution | Directory Open Access Journal |
| issn | 0102-7638 1678-9741 |
| language | English |
| last_indexed | 2024-04-14T00:35:15Z |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| record_format | Article |
| series | Brazilian Journal of Cardiovascular Surgery |
| spelling | doaj.art-b4b868413ff445f18120ed29abbfd7c52022-12-22T02:22:24ZengSociedade Brasileira de Cirurgia CardiovascularBrazilian Journal of Cardiovascular Surgery0102-76381678-974134327127810.21470/1678-9741-2018-0243S0102-76382019000300271Comparative Analysis of Myocardial Protection with HTK Solution and Hypothermic Hyperkalemic Blood Solution in the Correction of Acyanogenic Congenital Cardiopathies - A Randomized StudyAcrisio Sales ValenteGustavo Porto LustosaLia Alves Martins MotaAdriano LimaFernando Antônio de MesquitaAloísio GondimFábio Alércio RodriguesRonald Guedes PompeuKlébia Castelo BrancoAbstract Objective: The goal of the present study was to compare the myocardial protection obtained with histidine-tryptophan-ketoglutarate (HTK) cardioplegic solution (Custodiol®) and with intermittent hypothermic blood solution. Methods: Two homogenous groups of 25 children with acyanotic congenital heart disease who underwent total correction with mean aortic clamping time of 60 minutes were evaluated in this randomized study. Troponin and creatine kinase-MB curves, vasoactive-inotropic score, and left ventricular function were obtained by echocardiogram in each group. The values were correlated and presented through graphs and tables after adequate statistical treatment. Results: It was observed that values of all the studied variables varied over time, but there was no difference between the groups. Conclusion: We conclude that in patients with acyanotic congenital cardiopathies submitted to total surgical correction, mean aortic clamping time around one hour, and cardiopulmonary bypass with moderate hypothermia, the HTK crystalloid cardioplegic solution offers the same myocardial protection as the cold-blood hyperkalemic cardioplegic solution analyzed, according to the variables considered in our study model.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382019000300271&lng=en&tlng=enCongenital Heart Disease, CHDCardiopulmonary Bypass, CPB (Incl Set-Ups, Equipment, Surface Coatings, Etc.), PediatricMyocardial Protection/CardioplegiaMyocardial Injury (Incl Blunt, Penetrating, Iatrogenic) |
| spellingShingle | Acrisio Sales Valente Gustavo Porto Lustosa Lia Alves Martins Mota Adriano Lima Fernando Antônio de Mesquita Aloísio Gondim Fábio Alércio Rodrigues Ronald Guedes Pompeu Klébia Castelo Branco Comparative Analysis of Myocardial Protection with HTK Solution and Hypothermic Hyperkalemic Blood Solution in the Correction of Acyanogenic Congenital Cardiopathies - A Randomized Study Brazilian Journal of Cardiovascular Surgery Congenital Heart Disease, CHD Cardiopulmonary Bypass, CPB (Incl Set-Ups, Equipment, Surface Coatings, Etc.), Pediatric Myocardial Protection/Cardioplegia Myocardial Injury (Incl Blunt, Penetrating, Iatrogenic) |
| title | Comparative Analysis of Myocardial Protection with HTK Solution and Hypothermic Hyperkalemic Blood Solution in the Correction of Acyanogenic Congenital Cardiopathies - A Randomized Study |
| title_full | Comparative Analysis of Myocardial Protection with HTK Solution and Hypothermic Hyperkalemic Blood Solution in the Correction of Acyanogenic Congenital Cardiopathies - A Randomized Study |
| title_fullStr | Comparative Analysis of Myocardial Protection with HTK Solution and Hypothermic Hyperkalemic Blood Solution in the Correction of Acyanogenic Congenital Cardiopathies - A Randomized Study |
| title_full_unstemmed | Comparative Analysis of Myocardial Protection with HTK Solution and Hypothermic Hyperkalemic Blood Solution in the Correction of Acyanogenic Congenital Cardiopathies - A Randomized Study |
| title_short | Comparative Analysis of Myocardial Protection with HTK Solution and Hypothermic Hyperkalemic Blood Solution in the Correction of Acyanogenic Congenital Cardiopathies - A Randomized Study |
| title_sort | comparative analysis of myocardial protection with htk solution and hypothermic hyperkalemic blood solution in the correction of acyanogenic congenital cardiopathies a randomized study |
| topic | Congenital Heart Disease, CHD Cardiopulmonary Bypass, CPB (Incl Set-Ups, Equipment, Surface Coatings, Etc.), Pediatric Myocardial Protection/Cardioplegia Myocardial Injury (Incl Blunt, Penetrating, Iatrogenic) |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382019000300271&lng=en&tlng=en |
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