M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue
Abstract Adipose tissue (AT) is composed not only of adipocytes, but also of macrophages, endothelial cells and preadipocytes. Macrophages are an important component of AT, and are involved in tissue homeostasis, tissue repair and fibrosis. AT‐resident macrophages are categorized into two subtypes,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-11-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13114 |
| _version_ | 1818560955335835648 |
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| author | Allah Nawaz Kazuyuki Tobe |
| author_facet | Allah Nawaz Kazuyuki Tobe |
| author_sort | Allah Nawaz |
| collection | DOAJ |
| description | Abstract Adipose tissue (AT) is composed not only of adipocytes, but also of macrophages, endothelial cells and preadipocytes. Macrophages are an important component of AT, and are involved in tissue homeostasis, tissue repair and fibrosis. AT‐resident macrophages are categorized into two subtypes, the M1‐like and M2‐like macrophages. M2‐like macrophages are reported to play anti‐inflammatory roles, and to be involved in clearing and removal of dying/dead adipocytes, and recruiting adipocyte progenitors (APs). M2‐like macrophages are also reported to be involved in the promotion of fibrosis in a transforming growth factor‐β‐dependent manner. However, the precise roles of M2‐like macrophages in the AT have not yet been clearly delineated. Recently, we generated genetically engineered transgenic mice in which CD206+ M2‐like macrophages can be conditionally depleted. Unexpectedly, we found that the depletion of CD206+ M2‐like macrophages resulted in the enhanced generation of smaller adipocytes, improved insulin sensitivity and proliferation of APs. We further clarified that the CD206+ M2‐like macrophages directly interact with the APs to regulate their growth/differentiation and adipogenesis, thereby controlling adiposity and systemic insulin sensitivity. In the present review, we discuss how CD206+ M2‐like macrophages provide a niche for APs and maintain glucose homeostasis. |
| first_indexed | 2024-12-14T00:44:53Z |
| format | Article |
| id | doaj.art-b4b89c2c15a1434286a2913619e38938 |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-14T00:44:53Z |
| publishDate | 2019-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-b4b89c2c15a1434286a2913619e389382022-12-21T23:24:11ZengWileyJournal of Diabetes Investigation2040-11162040-11242019-11-011061394140010.1111/jdi.13114M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissueAllah Nawaz0Kazuyuki Tobe1First Department of Internal Medicine University of Toyama ToyamaJapanFirst Department of Internal Medicine University of Toyama ToyamaJapanAbstract Adipose tissue (AT) is composed not only of adipocytes, but also of macrophages, endothelial cells and preadipocytes. Macrophages are an important component of AT, and are involved in tissue homeostasis, tissue repair and fibrosis. AT‐resident macrophages are categorized into two subtypes, the M1‐like and M2‐like macrophages. M2‐like macrophages are reported to play anti‐inflammatory roles, and to be involved in clearing and removal of dying/dead adipocytes, and recruiting adipocyte progenitors (APs). M2‐like macrophages are also reported to be involved in the promotion of fibrosis in a transforming growth factor‐β‐dependent manner. However, the precise roles of M2‐like macrophages in the AT have not yet been clearly delineated. Recently, we generated genetically engineered transgenic mice in which CD206+ M2‐like macrophages can be conditionally depleted. Unexpectedly, we found that the depletion of CD206+ M2‐like macrophages resulted in the enhanced generation of smaller adipocytes, improved insulin sensitivity and proliferation of APs. We further clarified that the CD206+ M2‐like macrophages directly interact with the APs to regulate their growth/differentiation and adipogenesis, thereby controlling adiposity and systemic insulin sensitivity. In the present review, we discuss how CD206+ M2‐like macrophages provide a niche for APs and maintain glucose homeostasis.https://doi.org/10.1111/jdi.13114Adipocyte progenitorsAdipose tissue nicheM2‐like macrophages |
| spellingShingle | Allah Nawaz Kazuyuki Tobe M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue Journal of Diabetes Investigation Adipocyte progenitors Adipose tissue niche M2‐like macrophages |
| title | M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue |
| title_full | M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue |
| title_fullStr | M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue |
| title_full_unstemmed | M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue |
| title_short | M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue |
| title_sort | m2 like macrophages serve as a niche for adipocyte progenitors in adipose tissue |
| topic | Adipocyte progenitors Adipose tissue niche M2‐like macrophages |
| url | https://doi.org/10.1111/jdi.13114 |
| work_keys_str_mv | AT allahnawaz m2likemacrophagesserveasanicheforadipocyteprogenitorsinadiposetissue AT kazuyukitobe m2likemacrophagesserveasanicheforadipocyteprogenitorsinadiposetissue |