Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release
Drug delivery system is an amazing tool which is widely used for drug protection and its controlled release in order to enhance drug bioavailability, reduce side effects and therefore to improve overall therapy. Hydrogels have been attracted great attention as drug carriers due to their great phy...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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University of Banja Luka, Faculty of Technology
2022-12-01
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| Series: | Journal of Chemists, Technologists and Environmentalists |
| Subjects: | |
| Online Access: | https://glasnik.tf.unibl.org/article/190 |
| _version_ | 1827596000849559552 |
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| author | Olga J. Pantic Rada V. Pjanovic Vesna V. Panic Sanja I. Savic Pavle M. Spasojevic Maja D. Markovic |
| author_facet | Olga J. Pantic Rada V. Pjanovic Vesna V. Panic Sanja I. Savic Pavle M. Spasojevic Maja D. Markovic |
| author_sort | Olga J. Pantic |
| collection | DOAJ |
| description | Drug delivery system is an amazing tool which is widely used for drug
protection and its controlled release in order to enhance drug bioavailability,
reduce side effects and therefore to improve overall therapy. Hydrogels have
been attracted great attention as drug carriers due to their great physicochemical
properties, similarity to the living tissues and biocompatibility. One group of
pH sensitive hydrogels are based on poly(methacrylic acid) (PMAA). These
non-toxic hydrogels are used as drug delivery system because they swell as
a response to the change in pH of external environment and drug is being
released during the process. In present study, in order to improve the control of
drug release rate, caffeine was encapsulated in liposomes which were further
embedded into PMC hydrogel (PMCL). It was investigated how the change in
neutralization degree of methacrylic acid affect the swelling degree of PMCL
hydrogels and caffeine release in two environments at 37 °C for 24 h: 0.1 M
hydrochloride acid (pH 1) and phosphate buffer with pH value of 6.8 (pH 6.8), as
a simulation of pH environment in human stomach and intestines, respectively.
Obtained results show that PMCL hydrogels have great potential for controlled
release of poorly water-soluble drugs in human intestines. |
| first_indexed | 2024-03-09T03:03:13Z |
| format | Article |
| id | doaj.art-b4b9867fc6f3420a9f932f4becf9bdfb |
| institution | Directory Open Access Journal |
| issn | 2712-1267 |
| language | English |
| last_indexed | 2024-03-09T03:03:13Z |
| publishDate | 2022-12-01 |
| publisher | University of Banja Luka, Faculty of Technology |
| record_format | Article |
| series | Journal of Chemists, Technologists and Environmentalists |
| spelling | doaj.art-b4b9867fc6f3420a9f932f4becf9bdfb2023-12-04T10:49:12ZengUniversity of Banja Luka, Faculty of TechnologyJournal of Chemists, Technologists and Environmentalists2712-12672022-12-01311510.7251/JCTE2203001PEffect of neutralization degree of methacrylic acid on hydrogel swelling and drug releaseOlga J. Pantic0https://orcid.org/0000-0003-4667-2585 Rada V. Pjanovic1https://orcid.org/0000-0002-0817-182X Vesna V. Panic2https://orcid.org/0000-0003-3617-1533Sanja I. Savic3https://orcid.org/0000-0001-7021-9508Pavle M. Spasojevic 4https://orcid.org/0000-0001-8903-2102Maja D. Markovic5https://orcid.org/0000-0002-8466-8539University of Belgrade - Institute of Chemistry, Technology and Metallurgy, Belgrade, SerbiaUniversity of Belgrade - Faculty of Technology and Metallurgy, Belgrade, SerbiaUniversity of Belgrade - Innovation Center of Faculty of Technology and Metallurgy, Belgrade, SerbiaUniversity of Belgrade - Institute of Chemistry, Technology and Metallurgy, Belgrade, SerbiaUniversity of Belgrade - Innovation Center of Faculty of Technology and Metallurgy, Belgrade, SerbiaUniversity of Belgrade - Innovation Center of Faculty of Technology and Metallurgy, Belgrade, SerbiaDrug delivery system is an amazing tool which is widely used for drug protection and its controlled release in order to enhance drug bioavailability, reduce side effects and therefore to improve overall therapy. Hydrogels have been attracted great attention as drug carriers due to their great physicochemical properties, similarity to the living tissues and biocompatibility. One group of pH sensitive hydrogels are based on poly(methacrylic acid) (PMAA). These non-toxic hydrogels are used as drug delivery system because they swell as a response to the change in pH of external environment and drug is being released during the process. In present study, in order to improve the control of drug release rate, caffeine was encapsulated in liposomes which were further embedded into PMC hydrogel (PMCL). It was investigated how the change in neutralization degree of methacrylic acid affect the swelling degree of PMCL hydrogels and caffeine release in two environments at 37 °C for 24 h: 0.1 M hydrochloride acid (pH 1) and phosphate buffer with pH value of 6.8 (pH 6.8), as a simulation of pH environment in human stomach and intestines, respectively. Obtained results show that PMCL hydrogels have great potential for controlled release of poorly water-soluble drugs in human intestines.https://glasnik.tf.unibl.org/article/190hydrogelscaseinliposomesneutralization degreerelease kinetics |
| spellingShingle | Olga J. Pantic Rada V. Pjanovic Vesna V. Panic Sanja I. Savic Pavle M. Spasojevic Maja D. Markovic Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release Journal of Chemists, Technologists and Environmentalists hydrogels casein liposomes neutralization degree release kinetics |
| title | Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release |
| title_full | Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release |
| title_fullStr | Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release |
| title_full_unstemmed | Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release |
| title_short | Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release |
| title_sort | effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release |
| topic | hydrogels casein liposomes neutralization degree release kinetics |
| url | https://glasnik.tf.unibl.org/article/190 |
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