Screening of a Small Molecule Compound Library Identifies Toosendanin as an Inhibitor Against Bunyavirus and SARS-CoV-2

Screening of a Small Molecule Compound Library Identifies Toosendanin as an Inhibitor Against Bunyavirus and SARS-CoV-2

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus causing serious infectious disease with a high case-fatality of up to 50% in severe cases. Currently, no effective drug has been approved for the treatment of SFTSV infection. Here, we performed a high-throughp...

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Bibliographic Details
Main Authors: Shufen Li, Meidi Ye, Yuanqiao Chen, Yulan Zhang, Jiachen Li, Wei Liu, Hao Li, Ke Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
bunyavirus
SFTSV
SARS-CoV-2
anti-viral drug screening
toosendanin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.735223/full

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