Efficacy and tolerance of enteral nutrition in children with biliary atresia awaiting liver transplantation
ObjectivesMalnutrition is common in children with biliary atresia (BA) awaiting liver transplantation (LT). Few studies have evaluated the effectiveness of enteral nutrition (EN) in these patients. The objective of this work was to assess the efficacy and tolerance of EN in children with BA awaiting...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.983717/full |
| _version_ | 1798026393544556544 |
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| author | Elodie Privat Madeleine Aumar Madeleine Aumar Delphine Ley Delphine Ley Léa Chantal Tran Stéphanie Coopman Dominique Guimber Dominique Turck Dominique Turck Frédéric Gottrand Frédéric Gottrand |
| author_facet | Elodie Privat Madeleine Aumar Madeleine Aumar Delphine Ley Delphine Ley Léa Chantal Tran Stéphanie Coopman Dominique Guimber Dominique Turck Dominique Turck Frédéric Gottrand Frédéric Gottrand |
| author_sort | Elodie Privat |
| collection | DOAJ |
| description | ObjectivesMalnutrition is common in children with biliary atresia (BA) awaiting liver transplantation (LT). Few studies have evaluated the effectiveness of enteral nutrition (EN) in these patients. The objective of this work was to assess the efficacy and tolerance of EN in children with BA awaiting LT.MethodsA total of 31 patients with BA followed between 1995 and 2018 were retrospectively included. Anthropometric indicators (weight, length, and head circumference) and adverse effects of EN were noted at the start (T0) and the end (T1) of EN. The z-scores for anthropometric indicators were compared between T0 and T1.ResultsThe median age at T0 was 7 months (interquartile range [IQR] 5–9), and the median duration of EN was 9 months (IQR 3–17). The z-scores for anthropometric variables improved from T0 to T1: –1.6 (IQR –2.5 to –1.0) to –0.5 (IQR –1.8 to 0.3) for median weight for age; –1.3 (IQR –2.4 to 0) to –0.4 (IQR –2.0 to 0.7) for length for age; –0.9 (IQR –2.3 to –0.3) to –0.3 (IQR –1.2 to 0.1) for weight for length; and –1.2 (IQR –2.1 to –0.6) to –0.2 (IQR –1.6 to 0.4) for body mass index (p < 0.05 for all comparisons). Nearly all (94%) of the patients had a weight-for-length z-score > –2 at the end of EN; 23% had adverse effects and 10% had complications leading to the cessation of EN.ConclusionEN is effective and well tolerated in infants with BA awaiting LT. |
| first_indexed | 2024-04-11T18:34:37Z |
| format | Article |
| id | doaj.art-b4bdfc553cae4479aa750d4627989ea0 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-11T18:34:37Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pediatrics |
| spelling | doaj.art-b4bdfc553cae4479aa750d4627989ea02022-12-22T04:09:20ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-09-011010.3389/fped.2022.983717983717Efficacy and tolerance of enteral nutrition in children with biliary atresia awaiting liver transplantationElodie Privat0Madeleine Aumar1Madeleine Aumar2Delphine Ley3Delphine Ley4Léa Chantal Tran5Stéphanie Coopman6Dominique Guimber7Dominique Turck8Dominique Turck9Frédéric Gottrand10Frédéric Gottrand11Univ. Lille, Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Jeanne de Flandre Children’s Hospital, CHU Lille, Lille, FranceUniv. Lille, Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Jeanne de Flandre Children’s Hospital, CHU Lille, Lille, FranceUniv. Lille, Inserm, CHU Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, Lille, FranceUniv. Lille, Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Jeanne de Flandre Children’s Hospital, CHU Lille, Lille, FranceUniv. Lille, Inserm, CHU Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, Lille, FranceUniv. Lille, Inserm, CHU Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, Lille, FranceUniv. Lille, Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Jeanne de Flandre Children’s Hospital, CHU Lille, Lille, FranceUniv. Lille, Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Jeanne de Flandre Children’s Hospital, CHU Lille, Lille, FranceUniv. Lille, Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Jeanne de Flandre Children’s Hospital, CHU Lille, Lille, FranceUniv. Lille, Inserm, CHU Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, Lille, FranceUniv. Lille, Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Jeanne de Flandre Children’s Hospital, CHU Lille, Lille, FranceUniv. Lille, Inserm, CHU Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, Lille, FranceObjectivesMalnutrition is common in children with biliary atresia (BA) awaiting liver transplantation (LT). Few studies have evaluated the effectiveness of enteral nutrition (EN) in these patients. The objective of this work was to assess the efficacy and tolerance of EN in children with BA awaiting LT.MethodsA total of 31 patients with BA followed between 1995 and 2018 were retrospectively included. Anthropometric indicators (weight, length, and head circumference) and adverse effects of EN were noted at the start (T0) and the end (T1) of EN. The z-scores for anthropometric indicators were compared between T0 and T1.ResultsThe median age at T0 was 7 months (interquartile range [IQR] 5–9), and the median duration of EN was 9 months (IQR 3–17). The z-scores for anthropometric variables improved from T0 to T1: –1.6 (IQR –2.5 to –1.0) to –0.5 (IQR –1.8 to 0.3) for median weight for age; –1.3 (IQR –2.4 to 0) to –0.4 (IQR –2.0 to 0.7) for length for age; –0.9 (IQR –2.3 to –0.3) to –0.3 (IQR –1.2 to 0.1) for weight for length; and –1.2 (IQR –2.1 to –0.6) to –0.2 (IQR –1.6 to 0.4) for body mass index (p < 0.05 for all comparisons). Nearly all (94%) of the patients had a weight-for-length z-score > –2 at the end of EN; 23% had adverse effects and 10% had complications leading to the cessation of EN.ConclusionEN is effective and well tolerated in infants with BA awaiting LT.https://www.frontiersin.org/articles/10.3389/fped.2022.983717/fullbiliary atresiaenteral nutritionnasogastric tubestunted growthmalnutrition |
| spellingShingle | Elodie Privat Madeleine Aumar Madeleine Aumar Delphine Ley Delphine Ley Léa Chantal Tran Stéphanie Coopman Dominique Guimber Dominique Turck Dominique Turck Frédéric Gottrand Frédéric Gottrand Efficacy and tolerance of enteral nutrition in children with biliary atresia awaiting liver transplantation Frontiers in Pediatrics biliary atresia enteral nutrition nasogastric tube stunted growth malnutrition |
| title | Efficacy and tolerance of enteral nutrition in children with biliary atresia awaiting liver transplantation |
| title_full | Efficacy and tolerance of enteral nutrition in children with biliary atresia awaiting liver transplantation |
| title_fullStr | Efficacy and tolerance of enteral nutrition in children with biliary atresia awaiting liver transplantation |
| title_full_unstemmed | Efficacy and tolerance of enteral nutrition in children with biliary atresia awaiting liver transplantation |
| title_short | Efficacy and tolerance of enteral nutrition in children with biliary atresia awaiting liver transplantation |
| title_sort | efficacy and tolerance of enteral nutrition in children with biliary atresia awaiting liver transplantation |
| topic | biliary atresia enteral nutrition nasogastric tube stunted growth malnutrition |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.983717/full |
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