Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice

Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice

Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive symptoms of learning and memory deficits. Such cognitive impairments are attributed to brain atrophy resulting from progressive neuronal and synaptic loss; therefore, alleviation of neural cell death is...

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Bibliographic Details
Main Authors: Seung‐Hoon Yang, Dongkeun Kenneth Lee, Jisu Shin, Sejin Lee, Seungyeop Baek, Jiyoon Kim, Hoyong Jung, Jung‐Mi Hah, YoungSoo Kim
Format: Article
Language:English
Published: Springer Nature 2017-01-01
Series:EMBO Molecular Medicine
Subjects:
Alzheimer's disease
Aβ aggregation
cognitive deficit
necrostatin‐1
tau hyperphosphorylation
Online Access:https://doi.org/10.15252/emmm.201606566

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