Comparison of intravenous sodium bicarbonate and sodium chloride combination versus intravenous sodium chloride hydration alone in reducing amphotericin B nephrotoxicity: a randomized clinical trial

Comparison of intravenous sodium bicarbonate and sodium chloride combination versus intravenous sodium chloride hydration alone in reducing amphotericin B nephrotoxicity: a randomized clinical trial

Background and purpose: The most important adverse reaction of amphotericin B (AmB) is nephrotoxicity. The aim of this study was to assess the potential effectiveness of intravenous saline + sodium bicarbonate versus intravenous sodium chloride hydration in preventing or attenuating AmB nephrotoxici...

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Bibliographic Details
Main Authors: Iman Karimzadeh, Asma Sepehr-Sobhani, Mohammad Javad Khoshnoud, Mohammad Mahdi Sagheb, Reza Vejdani, Atefeh Jalali, Motahareh Mahi-Birjand
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
amphotericin b; sodium bicarbonate; sodium chloride; nephrotoxicity; prevention.
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2020;volume=15;issue=6;spage=583;epage=591;aulast=Karimzadeh

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