Cutaneous Manifestations in Biological-Treated Inflammatory Bowel Disease Patients: A Narrative Review
The biologic era has greatly improved the treatment of Crohn’s disease and ulcerative colitis. Biologics can however induce a wide variety of skin eruptions, especially those targeting the TNF-α and Th17 pathway. These include infusion reactions, eczema, psoriasis, lupus, alopecia areata, vitiligo,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/5/1040 |
| _version_ | 1797415276954779648 |
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| author | Jo L. W. Lambert Sofie De Schepper Reinhart Speeckaert |
| author_facet | Jo L. W. Lambert Sofie De Schepper Reinhart Speeckaert |
| author_sort | Jo L. W. Lambert |
| collection | DOAJ |
| description | The biologic era has greatly improved the treatment of Crohn’s disease and ulcerative colitis. Biologics can however induce a wide variety of skin eruptions, especially those targeting the TNF-α and Th17 pathway. These include infusion reactions, eczema, psoriasis, lupus, alopecia areata, vitiligo, lichenoid reactions, granulomatous disorders, vasculitis, skin cancer, and cutaneous infections. It is important to recognize these conditions as treatment-induced adverse reactions and adapt the treatment strategy accordingly. Some conditions can be treated topically while others require cessation or switch of the biological therapy. TNF-α antagonists have the highest rate adverse skin eruptions followed by ustekinumab and anti-integrin receptor blockers. In this review, we provide an overview of the most common skin eruptions which can be encountered in clinical practice when treating IBD (Inflammatory bowel disease) patients and propose a therapeutic approach for each condition. |
| first_indexed | 2024-03-09T05:45:21Z |
| format | Article |
| id | doaj.art-b4c374dd63514fda85d6648471e69fe8 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T05:45:21Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b4c374dd63514fda85d6648471e69fe82023-12-03T12:21:46ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-01105104010.3390/jcm10051040Cutaneous Manifestations in Biological-Treated Inflammatory Bowel Disease Patients: A Narrative ReviewJo L. W. Lambert0Sofie De Schepper1Reinhart Speeckaert2Department of Dermatology, Ghent University Hospital, B-9000 Gent, BelgiumDepartment of Dermatology, Ghent University Hospital, B-9000 Gent, BelgiumDepartment of Dermatology, Ghent University Hospital, B-9000 Gent, BelgiumThe biologic era has greatly improved the treatment of Crohn’s disease and ulcerative colitis. Biologics can however induce a wide variety of skin eruptions, especially those targeting the TNF-α and Th17 pathway. These include infusion reactions, eczema, psoriasis, lupus, alopecia areata, vitiligo, lichenoid reactions, granulomatous disorders, vasculitis, skin cancer, and cutaneous infections. It is important to recognize these conditions as treatment-induced adverse reactions and adapt the treatment strategy accordingly. Some conditions can be treated topically while others require cessation or switch of the biological therapy. TNF-α antagonists have the highest rate adverse skin eruptions followed by ustekinumab and anti-integrin receptor blockers. In this review, we provide an overview of the most common skin eruptions which can be encountered in clinical practice when treating IBD (Inflammatory bowel disease) patients and propose a therapeutic approach for each condition.https://www.mdpi.com/2077-0383/10/5/1040inflammatory bowel diseaseskin manifestationstumor necrosis factor-alphabiological therapy |
| spellingShingle | Jo L. W. Lambert Sofie De Schepper Reinhart Speeckaert Cutaneous Manifestations in Biological-Treated Inflammatory Bowel Disease Patients: A Narrative Review Journal of Clinical Medicine inflammatory bowel disease skin manifestations tumor necrosis factor-alpha biological therapy |
| title | Cutaneous Manifestations in Biological-Treated Inflammatory Bowel Disease Patients: A Narrative Review |
| title_full | Cutaneous Manifestations in Biological-Treated Inflammatory Bowel Disease Patients: A Narrative Review |
| title_fullStr | Cutaneous Manifestations in Biological-Treated Inflammatory Bowel Disease Patients: A Narrative Review |
| title_full_unstemmed | Cutaneous Manifestations in Biological-Treated Inflammatory Bowel Disease Patients: A Narrative Review |
| title_short | Cutaneous Manifestations in Biological-Treated Inflammatory Bowel Disease Patients: A Narrative Review |
| title_sort | cutaneous manifestations in biological treated inflammatory bowel disease patients a narrative review |
| topic | inflammatory bowel disease skin manifestations tumor necrosis factor-alpha biological therapy |
| url | https://www.mdpi.com/2077-0383/10/5/1040 |
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