Evaluation of the relationship between ovarian reserve with congenital anomalies and intramural uterine leiomyoma among infertile women: a cross-sectional study
Abstract Background Ovarian reserve is a crucial indicator of a woman’s fertility potential, which is determined by the quality and quantity of antral follicles and oocytes. However, certain factors such as endometriosis, pelvic inflammatory disease, myoma, and the natural process of aging can lead...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-023-01149-7 |
| _version_ | 1797849922108653568 |
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| author | Ashraf Moini Mehri Kalhor Shahideh Jahanian Sadatmahalleh Maryam Niknejadi Malihe Nasiri Azar Yahyaei Shohreh Irani Seyedeh Saeedeh Mousavi Saeideh Mikaeili Negin Mirzaei |
| author_facet | Ashraf Moini Mehri Kalhor Shahideh Jahanian Sadatmahalleh Maryam Niknejadi Malihe Nasiri Azar Yahyaei Shohreh Irani Seyedeh Saeedeh Mousavi Saeideh Mikaeili Negin Mirzaei |
| author_sort | Ashraf Moini |
| collection | DOAJ |
| description | Abstract Background Ovarian reserve is a crucial indicator of a woman’s fertility potential, which is determined by the quality and quantity of antral follicles and oocytes. However, certain factors such as endometriosis, pelvic inflammatory disease, myoma, and the natural process of aging can lead to a poor ovarian response to stimulation, reducing a woman’s chances of conceiving. Objective To evaluate the effect of uterus congenital anomalies and uterine leiomyoma are associated on ovarian reserve. Methods The present cross-sectional study was performed on 321 infertile women in three groups consisted of 97 infertile women with intramural uterine leiomyoma and 81 infertile women with uterine anomalies and 143 infertile women without uterine anomalies and uterine leiomyoma during 2017–2019 in Royan Center. Sampling method was continuous and available. Data collection tool in this study was a questionnaire which was in two parts of individual variables and the second part was related to ultrasound results (number of antral follicles and ovarian volume) and laboratory tests (Anti-Mullerian Hormone (AMH) and Follicle-stimulating Hormone (FSH)). Ovarian reserve parameters were measured in three groups on the third day of the cycle in both groups. Data analysis was performed using SPSS software version 21. Quantitative variables were analyzed using t-test, qualitative variables were analyzed using chi-square test. Results The results of in laboratory parameters showed that there was no statistically significant difference between the three groups in FSH (2.35 ± 1.55, 2.07 ± 1.81, 2.31 ± 1.93) and AMH (6.84 ± 2.75,7.52 ± 3.14,6.93 ± 3.04), respectively (P > 0.05). The results of sonographic variables also showed that the variables include number of antral follicles in right ovarian, number of antral follicles in left ovarian have statistically significant between the three groups (5.73 ± 2.69,4.84 ± 3.14,6.66 ± 3.13), respectively (P < 0.05). Conclusion The results of the present study showed that uterine abnormalities and uterine leiomyoma with different mechanisms such as reduce of antral follicle numbers and the effect on uterine and ovarian blood flow lead to a decrease in ovarian reserve and infertility. Therefore, treatment and surgery can reduce these effects and improve the fertility of the affected women. |
| first_indexed | 2024-04-09T18:51:59Z |
| format | Article |
| id | doaj.art-b4c4f7493fa148fd8511bfb86dc8c32a |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-09T18:51:59Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-b4c4f7493fa148fd8511bfb86dc8c32a2023-04-09T11:24:20ZengBMCJournal of Ovarian Research1757-22152023-04-011611810.1186/s13048-023-01149-7Evaluation of the relationship between ovarian reserve with congenital anomalies and intramural uterine leiomyoma among infertile women: a cross-sectional studyAshraf Moini0Mehri Kalhor1Shahideh Jahanian Sadatmahalleh2Maryam Niknejadi3Malihe Nasiri4Azar Yahyaei5Shohreh Irani6Seyedeh Saeedeh Mousavi7Saeideh Mikaeili8Negin Mirzaei9Breast Disease Research Center (BDRC), Tehran University of Medical SciencesKowsar hospital, Qazviin University Medical of ScienceDepartment of Reproductive Health and Midwifery, Faculty of Medical Sciences, Tarbiat Modares UniversityDepartment of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECRDepartment of Basic Sciences, Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical SciencesDepartment of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECRDepartment of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECRDepartment of Reproductive Health and Midwifery, Faculty of Medical Sciences, Tarbiat Modares UniversityDepartment of Reproductive Health and Midwifery, Faculty of Medical Sciences, Tarbiat Modares UniversityRobinson Research Institute, Faculty of Health and Medical Sciences, University of AdelaideAbstract Background Ovarian reserve is a crucial indicator of a woman’s fertility potential, which is determined by the quality and quantity of antral follicles and oocytes. However, certain factors such as endometriosis, pelvic inflammatory disease, myoma, and the natural process of aging can lead to a poor ovarian response to stimulation, reducing a woman’s chances of conceiving. Objective To evaluate the effect of uterus congenital anomalies and uterine leiomyoma are associated on ovarian reserve. Methods The present cross-sectional study was performed on 321 infertile women in three groups consisted of 97 infertile women with intramural uterine leiomyoma and 81 infertile women with uterine anomalies and 143 infertile women without uterine anomalies and uterine leiomyoma during 2017–2019 in Royan Center. Sampling method was continuous and available. Data collection tool in this study was a questionnaire which was in two parts of individual variables and the second part was related to ultrasound results (number of antral follicles and ovarian volume) and laboratory tests (Anti-Mullerian Hormone (AMH) and Follicle-stimulating Hormone (FSH)). Ovarian reserve parameters were measured in three groups on the third day of the cycle in both groups. Data analysis was performed using SPSS software version 21. Quantitative variables were analyzed using t-test, qualitative variables were analyzed using chi-square test. Results The results of in laboratory parameters showed that there was no statistically significant difference between the three groups in FSH (2.35 ± 1.55, 2.07 ± 1.81, 2.31 ± 1.93) and AMH (6.84 ± 2.75,7.52 ± 3.14,6.93 ± 3.04), respectively (P > 0.05). The results of sonographic variables also showed that the variables include number of antral follicles in right ovarian, number of antral follicles in left ovarian have statistically significant between the three groups (5.73 ± 2.69,4.84 ± 3.14,6.66 ± 3.13), respectively (P < 0.05). Conclusion The results of the present study showed that uterine abnormalities and uterine leiomyoma with different mechanisms such as reduce of antral follicle numbers and the effect on uterine and ovarian blood flow lead to a decrease in ovarian reserve and infertility. Therefore, treatment and surgery can reduce these effects and improve the fertility of the affected women.https://doi.org/10.1186/s13048-023-01149-7Ovarian reserveUterine Leiomyoma Uterus congenital anomalyInfertility |
| spellingShingle | Ashraf Moini Mehri Kalhor Shahideh Jahanian Sadatmahalleh Maryam Niknejadi Malihe Nasiri Azar Yahyaei Shohreh Irani Seyedeh Saeedeh Mousavi Saeideh Mikaeili Negin Mirzaei Evaluation of the relationship between ovarian reserve with congenital anomalies and intramural uterine leiomyoma among infertile women: a cross-sectional study Journal of Ovarian Research Ovarian reserve Uterine Leiomyoma Uterus congenital anomaly Infertility |
| title | Evaluation of the relationship between ovarian reserve with congenital anomalies and intramural uterine leiomyoma among infertile women: a cross-sectional study |
| title_full | Evaluation of the relationship between ovarian reserve with congenital anomalies and intramural uterine leiomyoma among infertile women: a cross-sectional study |
| title_fullStr | Evaluation of the relationship between ovarian reserve with congenital anomalies and intramural uterine leiomyoma among infertile women: a cross-sectional study |
| title_full_unstemmed | Evaluation of the relationship between ovarian reserve with congenital anomalies and intramural uterine leiomyoma among infertile women: a cross-sectional study |
| title_short | Evaluation of the relationship between ovarian reserve with congenital anomalies and intramural uterine leiomyoma among infertile women: a cross-sectional study |
| title_sort | evaluation of the relationship between ovarian reserve with congenital anomalies and intramural uterine leiomyoma among infertile women a cross sectional study |
| topic | Ovarian reserve Uterine Leiomyoma Uterus congenital anomaly Infertility |
| url | https://doi.org/10.1186/s13048-023-01149-7 |
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