Siderophore‑antibiotic conjugates: structural diversity and antibacterial activity
Due to uncontrolled growth of antimicrobial resistance, in the near future humanity may return to the «pre-antibiotic era» with no reliable antimicrobial therapy even for previously easily treatable infectious diseases. One of possible solutions is improved delivery of antibiotics to antibiotic-resi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
2022-12-01
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| Series: | Клиническая микробиология и антимикробная химиотерапия |
| Subjects: | |
| Online Access: | https://cmac-journal.ru/publication/2022/4/cmac-2022-t24-n4-p314/cmac-2022-t24-n4-p314.pdf |
| _version_ | 1797866657805238272 |
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| author | Chernyshov V.V. Kuzovlev A.S. Cherepanova N.D. Kasatkina M.A. Ivanov R.A. |
| author_facet | Chernyshov V.V. Kuzovlev A.S. Cherepanova N.D. Kasatkina M.A. Ivanov R.A. |
| author_sort | Chernyshov V.V. |
| collection | DOAJ |
| description | Due to uncontrolled growth of antimicrobial resistance, in the near future humanity may return to the «pre-antibiotic era» with no reliable antimicrobial therapy even for previously easily treatable infectious diseases. One of possible solutions is improved delivery of antibiotics to antibiotic-resistant bacterial strains by conjugating them with siderophores (small molecules secreted by microorganisms to absorb essential Fe(III)). The siderophore-modified antibiotic (sideromycin), like a Trojan horse, permeates the bacterial cell as a complex with Fe(III), allowing the antibiotic to reach its biological target. In this review, we describe the structural diversity of siderophore-antibiotic conjugates with the focus on the structure of sideromycin as well as on the relationship between the structure of sideromycin and its antibacterial activity. We analyze main representatives of various classes of siderophores; the structural diversity of sideromycins and their antibacterial activity discussed in detail. |
| first_indexed | 2024-04-09T23:28:52Z |
| format | Article |
| id | doaj.art-b4c56681093347269586f4bdca0ca390 |
| institution | Directory Open Access Journal |
| issn | 1684-4386 2686-9586 |
| language | Russian |
| last_indexed | 2024-04-09T23:28:52Z |
| publishDate | 2022-12-01 |
| publisher | Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy |
| record_format | Article |
| series | Клиническая микробиология и антимикробная химиотерапия |
| spelling | doaj.art-b4c56681093347269586f4bdca0ca3902023-03-21T08:26:20ZrusInterregional Association for Clinical Microbiology and Antimicrobial ChemotherapyКлиническая микробиология и антимикробная химиотерапия1684-43862686-95862022-12-0124431434410.36488/cmac.2022.4.314-344cmac-2022-t24-n4-p314Siderophore‑antibiotic conjugates: structural diversity and antibacterial activityChernyshov V.V.0Kuzovlev A.S.1Cherepanova N.D.2Kasatkina M.A.3Ivanov R.A.4Sirius University of Science and Technology, Krasnodar region, RussiaSirius University of Science and Technology, Krasnodar region, RussiaSirius University of Science and Technology, Krasnodar region, RussiaSirius University of Science and Technology, Krasnodar region, RussiaSirius University of Science and Technology, Krasnodar region, RussiaDue to uncontrolled growth of antimicrobial resistance, in the near future humanity may return to the «pre-antibiotic era» with no reliable antimicrobial therapy even for previously easily treatable infectious diseases. One of possible solutions is improved delivery of antibiotics to antibiotic-resistant bacterial strains by conjugating them with siderophores (small molecules secreted by microorganisms to absorb essential Fe(III)). The siderophore-modified antibiotic (sideromycin), like a Trojan horse, permeates the bacterial cell as a complex with Fe(III), allowing the antibiotic to reach its biological target. In this review, we describe the structural diversity of siderophore-antibiotic conjugates with the focus on the structure of sideromycin as well as on the relationship between the structure of sideromycin and its antibacterial activity. We analyze main representatives of various classes of siderophores; the structural diversity of sideromycins and their antibacterial activity discussed in detail.https://cmac-journal.ru/publication/2022/4/cmac-2022-t24-n4-p314/cmac-2022-t24-n4-p314.pdfsiderophoresantibiotic resistanceantibacterial agentssideromycinssiderophoreantibiotic conjugates |
| spellingShingle | Chernyshov V.V. Kuzovlev A.S. Cherepanova N.D. Kasatkina M.A. Ivanov R.A. Siderophore‑antibiotic conjugates: structural diversity and antibacterial activity Клиническая микробиология и антимикробная химиотерапия siderophores antibiotic resistance antibacterial agents sideromycins siderophoreantibiotic conjugates |
| title | Siderophore‑antibiotic conjugates: structural diversity and antibacterial activity |
| title_full | Siderophore‑antibiotic conjugates: structural diversity and antibacterial activity |
| title_fullStr | Siderophore‑antibiotic conjugates: structural diversity and antibacterial activity |
| title_full_unstemmed | Siderophore‑antibiotic conjugates: structural diversity and antibacterial activity |
| title_short | Siderophore‑antibiotic conjugates: structural diversity and antibacterial activity |
| title_sort | siderophore antibiotic conjugates structural diversity and antibacterial activity |
| topic | siderophores antibiotic resistance antibacterial agents sideromycins siderophoreantibiotic conjugates |
| url | https://cmac-journal.ru/publication/2022/4/cmac-2022-t24-n4-p314/cmac-2022-t24-n4-p314.pdf |
| work_keys_str_mv | AT chernyshovvv siderophoreantibioticconjugatesstructuraldiversityandantibacterialactivity AT kuzovlevas siderophoreantibioticconjugatesstructuraldiversityandantibacterialactivity AT cherepanovand siderophoreantibioticconjugatesstructuraldiversityandantibacterialactivity AT kasatkinama siderophoreantibioticconjugatesstructuraldiversityandantibacterialactivity AT ivanovra siderophoreantibioticconjugatesstructuraldiversityandantibacterialactivity |