Adult granulosa cell tumor associated with endometrial carcinoma: a case report

<p>Abstract</p> <p>Introduction</p> <p>If strict criteria for the diagnosis of carcinoma are used and all patients with granulosa cell tumors are considered, the best estimate of the incidence of associated endometrial carcinomas is under 5%. In patients with granulosa...

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Main Authors: Eke Ahizechukwu C, Eleje George U, Ikpeze Okechukwu C, Ukah Cornelius O
Format: Article
Language:English
Published: BMC 2011-08-01
Series:Journal of Medical Case Reports
Online Access:http://www.jmedicalcasereports.com/content/5/1/340
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author Eke Ahizechukwu C
Eleje George U
Ikpeze Okechukwu C
Ukah Cornelius O
author_facet Eke Ahizechukwu C
Eleje George U
Ikpeze Okechukwu C
Ukah Cornelius O
author_sort Eke Ahizechukwu C
collection DOAJ
description <p>Abstract</p> <p>Introduction</p> <p>If strict criteria for the diagnosis of carcinoma are used and all patients with granulosa cell tumors are considered, the best estimate of the incidence of associated endometrial carcinomas is under 5%. In patients with granulosa cell tumors, estrogen-dependent endometrial cancers are rarely found, and most of these endometrial cancers are well-differentiated endometrioid adenocarcinomas that carry a good prognosis when detected early.</p> <p>Case presentation</p> <p>We report the case of a 65-year-old post-menopausal Nigerian woman of the Igbo tribe with an adult granulosa cell tumor that was initially treated as endometrial carcinoma. She underwent a total abdominal hysterectomy and a bilateral salpingo-oophorectomy after histopathologic confirmation of a well-differentiated granulosa cell tumor of the ovary and a nuclear grade 1 adenocarcinoma of the endometrium (International Federation of Obstetricians and Gynecologists stage 1B). She had a good post-operative recovery and was discharged 10 days after treatment.</p> <p>Conclusion</p> <p>The association between adult granulosa cell tumors of the ovary and endometrial carcinomas is rare. A high index of suspicion as well as good imaging and histopathologic analyses are important in making this diagnosis.</p>
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spelling doaj.art-b4c78b6fb7784b3f94fe0296187bf9e32022-12-22T03:28:07ZengBMCJournal of Medical Case Reports1752-19472011-08-015134010.1186/1752-1947-5-340Adult granulosa cell tumor associated with endometrial carcinoma: a case reportEke Ahizechukwu CEleje George UIkpeze Okechukwu CUkah Cornelius O<p>Abstract</p> <p>Introduction</p> <p>If strict criteria for the diagnosis of carcinoma are used and all patients with granulosa cell tumors are considered, the best estimate of the incidence of associated endometrial carcinomas is under 5%. In patients with granulosa cell tumors, estrogen-dependent endometrial cancers are rarely found, and most of these endometrial cancers are well-differentiated endometrioid adenocarcinomas that carry a good prognosis when detected early.</p> <p>Case presentation</p> <p>We report the case of a 65-year-old post-menopausal Nigerian woman of the Igbo tribe with an adult granulosa cell tumor that was initially treated as endometrial carcinoma. She underwent a total abdominal hysterectomy and a bilateral salpingo-oophorectomy after histopathologic confirmation of a well-differentiated granulosa cell tumor of the ovary and a nuclear grade 1 adenocarcinoma of the endometrium (International Federation of Obstetricians and Gynecologists stage 1B). She had a good post-operative recovery and was discharged 10 days after treatment.</p> <p>Conclusion</p> <p>The association between adult granulosa cell tumors of the ovary and endometrial carcinomas is rare. A high index of suspicion as well as good imaging and histopathologic analyses are important in making this diagnosis.</p>http://www.jmedicalcasereports.com/content/5/1/340
spellingShingle Eke Ahizechukwu C
Eleje George U
Ikpeze Okechukwu C
Ukah Cornelius O
Adult granulosa cell tumor associated with endometrial carcinoma: a case report
Journal of Medical Case Reports
title Adult granulosa cell tumor associated with endometrial carcinoma: a case report
title_full Adult granulosa cell tumor associated with endometrial carcinoma: a case report
title_fullStr Adult granulosa cell tumor associated with endometrial carcinoma: a case report
title_full_unstemmed Adult granulosa cell tumor associated with endometrial carcinoma: a case report
title_short Adult granulosa cell tumor associated with endometrial carcinoma: a case report
title_sort adult granulosa cell tumor associated with endometrial carcinoma a case report
url http://www.jmedicalcasereports.com/content/5/1/340
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AT elejegeorgeu adultgranulosacelltumorassociatedwithendometrialcarcinomaacasereport
AT ikpezeokechukwuc adultgranulosacelltumorassociatedwithendometrialcarcinomaacasereport
AT ukahcorneliuso adultgranulosacelltumorassociatedwithendometrialcarcinomaacasereport