Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside
Abstract Tendon is composed of dense fibrous connective tissues, connecting muscle at the myotendinous junction (MTJ) to bone at the enthesis and allowing mechanical force to transmit from muscle to bone. Tendon diseases occur at different zones of the tendon, including enthesis, MTJ and midsubstanc...
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-09-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-022-03113-6 |
| _version_ | 1811297567834636288 |
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| author | Ziming Chen Peilin Chen Monica Zheng Junjie Gao Delin Liu Allan Wang Qiujian Zheng Toby Leys Andrew Tai Minghao Zheng |
| author_facet | Ziming Chen Peilin Chen Monica Zheng Junjie Gao Delin Liu Allan Wang Qiujian Zheng Toby Leys Andrew Tai Minghao Zheng |
| author_sort | Ziming Chen |
| collection | DOAJ |
| description | Abstract Tendon is composed of dense fibrous connective tissues, connecting muscle at the myotendinous junction (MTJ) to bone at the enthesis and allowing mechanical force to transmit from muscle to bone. Tendon diseases occur at different zones of the tendon, including enthesis, MTJ and midsubstance of the tendon, due to a variety of environmental and genetic factors which consequently result in different frequencies and recovery rates. Self-healing properties of tendons are limited, and cell therapeutic approaches in which injured tendon tissues are renewed by cell replenishment are highly sought after. Homologous use of individual’s tendon-derived cells, predominantly differentiated tenocytes and tendon-derived stem cells, is emerging as a treatment for tendinopathy through achieving minimal cell manipulation for clinical use. This is the first review summarizing the progress of tendon-derived cell therapy in clinical use and its challenges due to the structural complexity of tendons, heterogeneous composition of extracellular cell matrix and cells and unsuitable cell sources. Further to that, novel future perspectives to improve therapeutic effect in tendon-derived cell therapy based on current basic knowledge are discussed. |
| first_indexed | 2024-04-13T06:06:20Z |
| format | Article |
| id | doaj.art-b4c818ac427f4e58b4bc89bced4caefd |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-13T06:06:20Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-b4c818ac427f4e58b4bc89bced4caefd2022-12-22T02:59:15ZengBMCStem Cell Research & Therapy1757-65122022-09-0113112110.1186/s13287-022-03113-6Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedsideZiming Chen0Peilin Chen1Monica Zheng2Junjie Gao3Delin Liu4Allan Wang5Qiujian Zheng6Toby Leys7Andrew Tai8Minghao Zheng9Division of Surgery, Centre for Orthopaedic Research, Medical School, The University of Western AustraliaDivision of Surgery, Centre for Orthopaedic Research, Medical School, The University of Western AustraliaDepartment of Orthopaedic Surgery, Sir Charles Gairdner HospitalPerron Institute for Neurological and Translational ScienceDivision of Surgery, Centre for Orthopaedic Research, Medical School, The University of Western AustraliaDivision of Surgery, Centre for Orthopaedic Research, Medical School, The University of Western AustraliaThe Second School of Clinical Medicine, Southern Medical UniversityDepartment of Orthopaedic Surgery, Sir Charles Gairdner HospitalPerron Institute for Neurological and Translational ScienceDivision of Surgery, Centre for Orthopaedic Research, Medical School, The University of Western AustraliaAbstract Tendon is composed of dense fibrous connective tissues, connecting muscle at the myotendinous junction (MTJ) to bone at the enthesis and allowing mechanical force to transmit from muscle to bone. Tendon diseases occur at different zones of the tendon, including enthesis, MTJ and midsubstance of the tendon, due to a variety of environmental and genetic factors which consequently result in different frequencies and recovery rates. Self-healing properties of tendons are limited, and cell therapeutic approaches in which injured tendon tissues are renewed by cell replenishment are highly sought after. Homologous use of individual’s tendon-derived cells, predominantly differentiated tenocytes and tendon-derived stem cells, is emerging as a treatment for tendinopathy through achieving minimal cell manipulation for clinical use. This is the first review summarizing the progress of tendon-derived cell therapy in clinical use and its challenges due to the structural complexity of tendons, heterogeneous composition of extracellular cell matrix and cells and unsuitable cell sources. Further to that, novel future perspectives to improve therapeutic effect in tendon-derived cell therapy based on current basic knowledge are discussed.https://doi.org/10.1186/s13287-022-03113-6TendonTendon-derived stem cells (TDSCs)Myotendinous junction (MTJ)Midsubstance of tendonEnthesisTendinopathy |
| spellingShingle | Ziming Chen Peilin Chen Monica Zheng Junjie Gao Delin Liu Allan Wang Qiujian Zheng Toby Leys Andrew Tai Minghao Zheng Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside Stem Cell Research & Therapy Tendon Tendon-derived stem cells (TDSCs) Myotendinous junction (MTJ) Midsubstance of tendon Enthesis Tendinopathy |
| title | Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside |
| title_full | Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside |
| title_fullStr | Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside |
| title_full_unstemmed | Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside |
| title_short | Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside |
| title_sort | challenges and perspectives of tendon derived cell therapy for tendinopathy from bench to bedside |
| topic | Tendon Tendon-derived stem cells (TDSCs) Myotendinous junction (MTJ) Midsubstance of tendon Enthesis Tendinopathy |
| url | https://doi.org/10.1186/s13287-022-03113-6 |
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