Low-intensity exercise combined with sodium valproate attenuates kainic acid-induced seizures and associated co-morbidities by inhibiting NF-κB signaling in mice

Low-intensity exercise combined with sodium valproate attenuates kainic acid-induced seizures and associated co-morbidities by inhibiting NF-κB signaling in mice

Sodium valproate (VPA) is a broad-spectrum anticonvulsant that is effective both in adults and children suffering from epilepsy, but it causes psychiatric and behavioral side effects in patients with epilepsy. In addition, 30% of patients with epilepsy develop resistance to VPA. At present, regular...

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Bibliographic Details
Main Authors: Yuxiang Jia, Lele Tang, Yu Yao, Limin Zhuo, Dongxiao Qu, Xingxing Chen, Yonghua Ji, Jie Tao, Yudan Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Neurology
Subjects:
seizures
low-intensity exercise
sodium valproate
co-morbidities
TLR4/NF-κB pathway
inflammatory factors
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.993405/full

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