The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast Cancer
Epidemiological evidence suggests that non-steroidal anti-inflammatory drugs (NSAIDs) which act as cyclooxygenase (COX-2) inhibitors may reduce breast cancer incidence by up to 20%. These agents are often taken for pain relief by older women with osteoarthritis. Age is the major risk factor for brea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-05-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8247/3/5/1550/ |
| _version_ | 1818141958086852608 |
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| author | Sarah L. Horn Ian S. Fentiman |
| author_facet | Sarah L. Horn Ian S. Fentiman |
| author_sort | Sarah L. Horn |
| collection | DOAJ |
| description | Epidemiological evidence suggests that non-steroidal anti-inflammatory drugs (NSAIDs) which act as cyclooxygenase (COX-2) inhibitors may reduce breast cancer incidence by up to 20%. These agents are often taken for pain relief by older women with osteoarthritis. Age is the major risk factor for breast cancer in women with 50% cases being diagnosed in those aged >65 years. NSAIDs reduce serum estradiol by 17% in post-menopausal women and since most of these who develop breast cancers have estrogen receptor positive tumours; this suggests a possible preventative role. Careful use of these agents could provide a strategy for both relief of symptoms of osteoarthritis and also breast cancer prevention. Instead of conducting a randomised trial, proof of efficacy could be from an adequately powered cohort study within the breast screening programme. |
| first_indexed | 2024-12-11T11:08:08Z |
| format | Article |
| id | doaj.art-b4c8422bd23647198d8d97b319151fba |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-12-11T11:08:08Z |
| publishDate | 2010-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-b4c8422bd23647198d8d97b319151fba2022-12-22T01:09:39ZengMDPI AGPharmaceuticals1424-82472010-05-01351550156010.3390/ph3051550The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast CancerSarah L. HornIan S. FentimanEpidemiological evidence suggests that non-steroidal anti-inflammatory drugs (NSAIDs) which act as cyclooxygenase (COX-2) inhibitors may reduce breast cancer incidence by up to 20%. These agents are often taken for pain relief by older women with osteoarthritis. Age is the major risk factor for breast cancer in women with 50% cases being diagnosed in those aged >65 years. NSAIDs reduce serum estradiol by 17% in post-menopausal women and since most of these who develop breast cancers have estrogen receptor positive tumours; this suggests a possible preventative role. Careful use of these agents could provide a strategy for both relief of symptoms of osteoarthritis and also breast cancer prevention. Instead of conducting a randomised trial, proof of efficacy could be from an adequately powered cohort study within the breast screening programme.http://www.mdpi.com/1424-8247/3/5/1550/non-steroidal anti-inflammatory drugsbreast cancerchemoprevention |
| spellingShingle | Sarah L. Horn Ian S. Fentiman The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast Cancer Pharmaceuticals non-steroidal anti-inflammatory drugs breast cancer chemoprevention |
| title | The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast Cancer |
| title_full | The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast Cancer |
| title_fullStr | The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast Cancer |
| title_full_unstemmed | The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast Cancer |
| title_short | The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast Cancer |
| title_sort | role of non steroidal anti inflammatory drugs in the chemoprevention of breast cancer |
| topic | non-steroidal anti-inflammatory drugs breast cancer chemoprevention |
| url | http://www.mdpi.com/1424-8247/3/5/1550/ |
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