N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation â€
The sulfamide functional group is increasingly relevant in both medicinal and bioorganic chemistry. We report here practical access to a series of N2,N5-substituted five-membered cyclosulfamides. The five-membered heterocyclic motif was prepared starting from proteogenic amino acids and chlorosulfon...
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| Format: | Article |
| Language: | English |
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MDPI AG
2005-11-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/10/11/1387/ |
| _version_ | 1817997196559122432 |
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| author | N. Aouf Z. Regainia R. Djeribi A. Bendjeddou |
| author_facet | N. Aouf Z. Regainia R. Djeribi A. Bendjeddou |
| author_sort | N. Aouf |
| collection | DOAJ |
| description | The sulfamide functional group is increasingly relevant in both medicinal and bioorganic chemistry. We report here practical access to a series of N2,N5-substituted five-membered cyclosulfamides. The five-membered heterocyclic motif was prepared starting from proteogenic amino acids and chlorosulfonyl isocyanate via the Mitsunobu reaction. Selected chemical and spectral proprieties and the antimicrobial evaluation of these compounds are detailed. |
| first_indexed | 2024-04-14T02:33:32Z |
| format | Article |
| id | doaj.art-b4c8956441f84083b7b9714d69e77be3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-14T02:33:32Z |
| publishDate | 2005-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b4c8956441f84083b7b9714d69e77be32022-12-22T02:17:35ZengMDPI AGMolecules1420-30492005-11-0110111387139810.3390/10111387N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation â€N. AoufZ. RegainiaR. DjeribiA. BendjeddouThe sulfamide functional group is increasingly relevant in both medicinal and bioorganic chemistry. We report here practical access to a series of N2,N5-substituted five-membered cyclosulfamides. The five-membered heterocyclic motif was prepared starting from proteogenic amino acids and chlorosulfonyl isocyanate via the Mitsunobu reaction. Selected chemical and spectral proprieties and the antimicrobial evaluation of these compounds are detailed.http://www.mdpi.com/1420-3049/10/11/1387/Amino acidscyclic sulfamidescyclizationMitsunobu reactionpropionylationconstrained peptides. |
| spellingShingle | N. Aouf Z. Regainia R. Djeribi A. Bendjeddou N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation †Molecules Amino acids cyclic sulfamides cyclization Mitsunobu reaction propionylation constrained peptides. |
| title | N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation †|
| title_full | N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation †|
| title_fullStr | N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation †|
| title_full_unstemmed | N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation †|
| title_short | N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation †|
| title_sort | n na¢a€a™ substituted 1 2 5 thiadiazolidine 1 1 dioxides synthesis selected chemical and spectral proprieties and antimicrobial evaluation a¢a€ |
| topic | Amino acids cyclic sulfamides cyclization Mitsunobu reaction propionylation constrained peptides. |
| url | http://www.mdpi.com/1420-3049/10/11/1387/ |
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