Apigenin Increases SHIP-1 Expression, Promotes Tumoricidal Macrophages and Anti-Tumor Immune Responses in Murine Pancreatic Cancer

Apigenin Increases SHIP-1 Expression, Promotes Tumoricidal Macrophages and Anti-Tumor Immune Responses in Murine Pancreatic Cancer

Pancreatic cancer (PC) has an extremely poor prognosis due to the expansion of immunosuppressive myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM) in the inflammatory tumor microenvironment (TME), which halts the recruitment of effector immune cells and renders immunothe...

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Bibliographic Details
Main Authors: Krystal Villalobos-Ayala, Ivannie Ortiz Rivera, Ciara Alvarez, Kazim Husain, DeVon DeLoach, Gerald Krystal, Margaret L. Hibbs, Kun Jiang, Tomar Ghansah
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
SHIP-1
pancreatic cancer
apigenin
myeloid homeostasis
tumor immunity
Online Access:https://www.mdpi.com/2072-6694/12/12/3631

Internet

https://www.mdpi.com/2072-6694/12/12/3631

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