Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021
Eight new chromones, engyodontiumones A–H (1–8), and three new phenol derivatives (9–11) together with eight known polyketides (12–19) were isolated from the deep-sea-derived fungus Engyodontium album DFFSCS021. Their structures were identified by extensive spectroscopic analysis. Compounds 8 and 16...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-12-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/12/12/5902 |
| _version_ | 1811184347933310976 |
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| author | Qifeng Yao Jie Wang Xiaoyong Zhang Xuhua Nong Xinya Xu Shuhua Qi |
| author_facet | Qifeng Yao Jie Wang Xiaoyong Zhang Xuhua Nong Xinya Xu Shuhua Qi |
| author_sort | Qifeng Yao |
| collection | DOAJ |
| description | Eight new chromones, engyodontiumones A–H (1–8), and three new phenol derivatives (9–11) together with eight known polyketides (12–19) were isolated from the deep-sea-derived fungus Engyodontium album DFFSCS021. Their structures were identified by extensive spectroscopic analysis. Compounds 8 and 16 showed significant selective cytotoxicity against human histiocytic lymphoma U937 cell line with IC50 values of 4.9 and 8.8 μM, respectively. In addition, this is the first time to report that 8, 15 and 16 had mild antibacterial activity against Escherichia coli and Bacillus subtilis, and 15 showed potent antilarval activity against barnacle Balanus amphitrite larval settlement. |
| first_indexed | 2024-04-11T13:10:42Z |
| format | Article |
| id | doaj.art-b4cb59cf866340d29173797ec507b7c3 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T13:10:42Z |
| publishDate | 2014-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-b4cb59cf866340d29173797ec507b7c32022-12-22T04:22:35ZengMDPI AGMarine Drugs1660-33972014-12-0112125902591510.3390/md12125902md12125902Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021Qifeng Yao0Jie Wang1Xiaoyong Zhang2Xuhua Nong3Xinya Xu4Shuhua Qi5Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, Guangdong, ChinaKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, Guangdong, ChinaKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, Guangdong, ChinaKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, Guangdong, ChinaKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, Guangdong, ChinaKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, Guangdong, ChinaEight new chromones, engyodontiumones A–H (1–8), and three new phenol derivatives (9–11) together with eight known polyketides (12–19) were isolated from the deep-sea-derived fungus Engyodontium album DFFSCS021. Their structures were identified by extensive spectroscopic analysis. Compounds 8 and 16 showed significant selective cytotoxicity against human histiocytic lymphoma U937 cell line with IC50 values of 4.9 and 8.8 μM, respectively. In addition, this is the first time to report that 8, 15 and 16 had mild antibacterial activity against Escherichia coli and Bacillus subtilis, and 15 showed potent antilarval activity against barnacle Balanus amphitrite larval settlement.http://www.mdpi.com/1660-3397/12/12/5902Engyodontium albumpolyketidesspectroscopic datacytotoxicityantilarval |
| spellingShingle | Qifeng Yao Jie Wang Xiaoyong Zhang Xuhua Nong Xinya Xu Shuhua Qi Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021 Marine Drugs Engyodontium album polyketides spectroscopic data cytotoxicity antilarval |
| title | Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021 |
| title_full | Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021 |
| title_fullStr | Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021 |
| title_full_unstemmed | Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021 |
| title_short | Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021 |
| title_sort | cytotoxic polyketides from the deep sea derived fungus engyodontium album dffscs021 |
| topic | Engyodontium album polyketides spectroscopic data cytotoxicity antilarval |
| url | http://www.mdpi.com/1660-3397/12/12/5902 |
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