An In Vitro Study of the Effect of Cinnamaldehyde on the Growth of Candida albicans Compared to Nystatin and Fluconazole
Objective: Cinnamaldehyde is the main active component of cinnamon essential oil with antibacterial and antifungal effects. This in vitro study was done to investigate the effect of cinnamaldehyde on the growth of standard strain of Candida albicans (C. albicans) in comparison to nystatin suspension...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Aras Part Medical International Press
2015-07-01
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| Series: | Crescent Journal of Medical and Biological Sciences |
| Subjects: | |
| Online Access: | http://cjmb.org/PDF/CJMB-2-76.pdf |
| _version_ | 1818689119611518976 |
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| author | Rahemi Diyardokht Babaee Neda Kazemi Sohrab Sefidgar Seyyed Ali Asghar Moghadamnia Ali Akbar |
| author_facet | Rahemi Diyardokht Babaee Neda Kazemi Sohrab Sefidgar Seyyed Ali Asghar Moghadamnia Ali Akbar |
| author_sort | Rahemi Diyardokht |
| collection | DOAJ |
| description | Objective: Cinnamaldehyde is the main active component of cinnamon essential oil with antibacterial and antifungal effects. This in vitro study was done to investigate the effect of cinnamaldehyde on the growth of standard strain of Candida albicans (C. albicans) in comparison to nystatin suspension and fluconazole.
Materials and Methods: The tests were designed for the three groups of this study namely cinnamaldehyde, fluconazole and nystatin. Standard strain of C. albicans (PTCC 5027) was used. Three methods namely disc diffusion, well diffusion and microdilution were used. Based on elevation of cinnamaldehyde concentrations, its antifungal effect was increased.
Results: The minimum inhibitory concentration (MIC) of antifungal effect of cinnamaldehyde was 0.312 μl/ml. This effect is similar to the effect of 100000 IU/ml nystatin in concentration of 20 μl/ml and 1% fluconazole in concentration of 40 μl/ml. The mean (±SD) of inhibition zone diameter in concentration of 80 μl/ml for disc and well diffusion were 60.4 (±2.2) and 70 (±3.5) mm, respectively.
Conclusion: These inhibition zones were larger than the zones for fluconazole and nystatin groups. According to the results, cinnamaldehyde has dose-dependent anti-C. albicans effect. In some concentrations, the cinnamaldehyde effect is similar to fluconazole and nystatin. |
| first_indexed | 2024-12-17T12:05:02Z |
| format | Article |
| id | doaj.art-b4cd7e1aa0b44ee59a635270608453be |
| institution | Directory Open Access Journal |
| issn | 2148-9696 |
| language | English |
| last_indexed | 2024-12-17T12:05:02Z |
| publishDate | 2015-07-01 |
| publisher | Aras Part Medical International Press |
| record_format | Article |
| series | Crescent Journal of Medical and Biological Sciences |
| spelling | doaj.art-b4cd7e1aa0b44ee59a635270608453be2022-12-21T21:49:39ZengAras Part Medical International PressCrescent Journal of Medical and Biological Sciences2148-96962015-07-01237680CJMB_20150721044515An In Vitro Study of the Effect of Cinnamaldehyde on the Growth of Candida albicans Compared to Nystatin and FluconazoleRahemi Diyardokht0Babaee Neda1Kazemi Sohrab2Sefidgar Seyyed Ali Asghar3Moghadamnia Ali Akbar4Department of Oral Medicine, Babol University of Medical Sciences, Babol, Iran. Department of Oral Medicine, Babol University of Medical Sciences, Babol, Iran. Department of Pharmacology and Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran. Department of Mycology, Babol University of Medical Sciences, Babol, Iran.Department of Pharmacology and Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran. Objective: Cinnamaldehyde is the main active component of cinnamon essential oil with antibacterial and antifungal effects. This in vitro study was done to investigate the effect of cinnamaldehyde on the growth of standard strain of Candida albicans (C. albicans) in comparison to nystatin suspension and fluconazole. Materials and Methods: The tests were designed for the three groups of this study namely cinnamaldehyde, fluconazole and nystatin. Standard strain of C. albicans (PTCC 5027) was used. Three methods namely disc diffusion, well diffusion and microdilution were used. Based on elevation of cinnamaldehyde concentrations, its antifungal effect was increased. Results: The minimum inhibitory concentration (MIC) of antifungal effect of cinnamaldehyde was 0.312 μl/ml. This effect is similar to the effect of 100000 IU/ml nystatin in concentration of 20 μl/ml and 1% fluconazole in concentration of 40 μl/ml. The mean (±SD) of inhibition zone diameter in concentration of 80 μl/ml for disc and well diffusion were 60.4 (±2.2) and 70 (±3.5) mm, respectively. Conclusion: These inhibition zones were larger than the zones for fluconazole and nystatin groups. According to the results, cinnamaldehyde has dose-dependent anti-C. albicans effect. In some concentrations, the cinnamaldehyde effect is similar to fluconazole and nystatin.http://cjmb.org/PDF/CJMB-2-76.pdfCandida albicansCinnamaldehydeCinnamonDMSO |
| spellingShingle | Rahemi Diyardokht Babaee Neda Kazemi Sohrab Sefidgar Seyyed Ali Asghar Moghadamnia Ali Akbar An In Vitro Study of the Effect of Cinnamaldehyde on the Growth of Candida albicans Compared to Nystatin and Fluconazole Crescent Journal of Medical and Biological Sciences Candida albicans Cinnamaldehyde Cinnamon DMSO |
| title | An In Vitro Study of the Effect of Cinnamaldehyde on the Growth of Candida albicans Compared to Nystatin and Fluconazole |
| title_full | An In Vitro Study of the Effect of Cinnamaldehyde on the Growth of Candida albicans Compared to Nystatin and Fluconazole |
| title_fullStr | An In Vitro Study of the Effect of Cinnamaldehyde on the Growth of Candida albicans Compared to Nystatin and Fluconazole |
| title_full_unstemmed | An In Vitro Study of the Effect of Cinnamaldehyde on the Growth of Candida albicans Compared to Nystatin and Fluconazole |
| title_short | An In Vitro Study of the Effect of Cinnamaldehyde on the Growth of Candida albicans Compared to Nystatin and Fluconazole |
| title_sort | in vitro study of the effect of cinnamaldehyde on the growth of candida albicans compared to nystatin and fluconazole |
| topic | Candida albicans Cinnamaldehyde Cinnamon DMSO |
| url | http://cjmb.org/PDF/CJMB-2-76.pdf |
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