The telomerase activator TA-65 protects from cigarette smoke-induced small airway remodeling in mice through extra-telomeric effects

The telomerase activator TA-65 protects from cigarette smoke-induced small airway remodeling in mice through extra-telomeric effects

Abstract Small airway remodeling (SAR) is a key phenomenon of airflow obstruction in smokers, leading to chronic obstructive pulmonary disease (COPD). SAR results in an increased thickness of small airway walls, with a combination of peribronchiolar fibrosis with increased fibrous tissue and accumul...

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Bibliographic Details
Main Authors: Arnaud Jean Florent Tiendrébéogo, Thibaud Soumagne, François Pellegrin, Maylis Dagouassat, Jeanne Tran Van Nhieu, Philippe Caramelle, Emmanuel N. Paul, Benjamin Even, Maeva Zysman, Yvon Julé, Abdoulaye Samb, Jorge Boczkowski, Sophie Lanone, Frédéric Schlemmer
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-25993-7

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