Association between Cough and Ambient Polycyclic Aromatic Hydrocarbons in Patients with Chronic Cough: An Observational Study in Two Regions of Japan
Ambient polycyclic aromatic hydrocarbons’ (PAHs) specific components are likely involved in respiratory disease development and exacerbation in children and adults. Airborne PAH exposure’s effects on cough symptoms in children and adults with chronic coughs in Kanazawa and Fukuoka, Japan, were inves...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/24/12505 |
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| author | Akinori Hara Hiroshi Odajima Hiroshi Matsuzaki Masaki Fujimura Tomoko Toma Taizo Wada Noriyuki Ohkura Jiaye Zhao Kim-Oanh Pham Keita Suzuki Hiromasa Tsujiguchi Akinori Takami Kazuichi Hayakawa Hiroyuki Nakamura |
| author_facet | Akinori Hara Hiroshi Odajima Hiroshi Matsuzaki Masaki Fujimura Tomoko Toma Taizo Wada Noriyuki Ohkura Jiaye Zhao Kim-Oanh Pham Keita Suzuki Hiromasa Tsujiguchi Akinori Takami Kazuichi Hayakawa Hiroyuki Nakamura |
| author_sort | Akinori Hara |
| collection | DOAJ |
| description | Ambient polycyclic aromatic hydrocarbons’ (PAHs) specific components are likely involved in respiratory disease development and exacerbation in children and adults. Airborne PAH exposure’s effects on cough symptoms in children and adults with chronic coughs in Kanazawa and Fukuoka, Japan, were investigated in this longitudinal study. A total of 98 patients with chronic coughs were enrolled and followed up between 1 April and 31 May 2020. The enrolled patients were non-smoking adults and children aged 3–83 years. Cough diaries were used to record and collect daily cough symptoms. High-performance liquid chromatography coupled with a fluorescence detector was used to determine the particulate PAH content in daily total suspended particles collected on quartz fiber filters. Ambient concentrations of fine particulate matter, nitrogen dioxide, and sulfur dioxide were obtained from local monitoring sites. Generalized estimated equations were used to estimate the association between daily PAHs and cough symptoms. Among nine PAHs measured, benz[<i>a</i>]anthracene (BaA) was significantly associated with cough symptoms for both lag4 and lag5 PAH exposure. These findings suggest that airborne specific PAHs, especially BaA, affect cough symptoms in children and adults with chronic cough. Further studies are needed to develop effective measures to prevent respiratory diseases against specific PAHs. |
| first_indexed | 2024-03-09T17:23:18Z |
| format | Article |
| id | doaj.art-b4d0c792f7da4ee5a6b52578c0a96011 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T17:23:18Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-b4d0c792f7da4ee5a6b52578c0a960112023-11-24T12:59:46ZengMDPI AGApplied Sciences2076-34172022-12-0112241250510.3390/app122412505Association between Cough and Ambient Polycyclic Aromatic Hydrocarbons in Patients with Chronic Cough: An Observational Study in Two Regions of JapanAkinori Hara0Hiroshi Odajima1Hiroshi Matsuzaki2Masaki Fujimura3Tomoko Toma4Taizo Wada5Noriyuki Ohkura6Jiaye Zhao7Kim-Oanh Pham8Keita Suzuki9Hiromasa Tsujiguchi10Akinori Takami11Kazuichi Hayakawa12Hiroyuki Nakamura13Department of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-8640, JapanDepartment of Pediatrics, National Hospital Organization Fukuoka National Hospital, Fukuoka 811-1394, JapanDepartment of Pediatrics, National Hospital Organization Fukuoka National Hospital, Fukuoka 811-1394, JapanRespiratory Medicine, National Hospital Organization Nanao Hospital, 8 bu 3-1 Matsuto-machi, Nanao 926-8531, JapanDepartment of Pediatrics, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-8640, JapanDepartment of Pediatrics, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-8640, JapanDepartment of Respiratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-8640, JapanDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-8640, JapanDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-8640, JapanDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-8640, JapanDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-8640, JapanRegional Environment Conservation Division, National Institute for Environmental Studies, Tsukuba 305-8506, JapanLow-Level Radioactivity Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Nomi 923-1224, JapanDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-8640, JapanAmbient polycyclic aromatic hydrocarbons’ (PAHs) specific components are likely involved in respiratory disease development and exacerbation in children and adults. Airborne PAH exposure’s effects on cough symptoms in children and adults with chronic coughs in Kanazawa and Fukuoka, Japan, were investigated in this longitudinal study. A total of 98 patients with chronic coughs were enrolled and followed up between 1 April and 31 May 2020. The enrolled patients were non-smoking adults and children aged 3–83 years. Cough diaries were used to record and collect daily cough symptoms. High-performance liquid chromatography coupled with a fluorescence detector was used to determine the particulate PAH content in daily total suspended particles collected on quartz fiber filters. Ambient concentrations of fine particulate matter, nitrogen dioxide, and sulfur dioxide were obtained from local monitoring sites. Generalized estimated equations were used to estimate the association between daily PAHs and cough symptoms. Among nine PAHs measured, benz[<i>a</i>]anthracene (BaA) was significantly associated with cough symptoms for both lag4 and lag5 PAH exposure. These findings suggest that airborne specific PAHs, especially BaA, affect cough symptoms in children and adults with chronic cough. Further studies are needed to develop effective measures to prevent respiratory diseases against specific PAHs.https://www.mdpi.com/2076-3417/12/24/12505polycyclic aromatic hydrocarbonparticulate matterchronic coughchildrenadultasthma |
| spellingShingle | Akinori Hara Hiroshi Odajima Hiroshi Matsuzaki Masaki Fujimura Tomoko Toma Taizo Wada Noriyuki Ohkura Jiaye Zhao Kim-Oanh Pham Keita Suzuki Hiromasa Tsujiguchi Akinori Takami Kazuichi Hayakawa Hiroyuki Nakamura Association between Cough and Ambient Polycyclic Aromatic Hydrocarbons in Patients with Chronic Cough: An Observational Study in Two Regions of Japan Applied Sciences polycyclic aromatic hydrocarbon particulate matter chronic cough children adult asthma |
| title | Association between Cough and Ambient Polycyclic Aromatic Hydrocarbons in Patients with Chronic Cough: An Observational Study in Two Regions of Japan |
| title_full | Association between Cough and Ambient Polycyclic Aromatic Hydrocarbons in Patients with Chronic Cough: An Observational Study in Two Regions of Japan |
| title_fullStr | Association between Cough and Ambient Polycyclic Aromatic Hydrocarbons in Patients with Chronic Cough: An Observational Study in Two Regions of Japan |
| title_full_unstemmed | Association between Cough and Ambient Polycyclic Aromatic Hydrocarbons in Patients with Chronic Cough: An Observational Study in Two Regions of Japan |
| title_short | Association between Cough and Ambient Polycyclic Aromatic Hydrocarbons in Patients with Chronic Cough: An Observational Study in Two Regions of Japan |
| title_sort | association between cough and ambient polycyclic aromatic hydrocarbons in patients with chronic cough an observational study in two regions of japan |
| topic | polycyclic aromatic hydrocarbon particulate matter chronic cough children adult asthma |
| url | https://www.mdpi.com/2076-3417/12/24/12505 |
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