A novel macrolide–Del-1 axis to regenerate bone in old age

A novel macrolide–Del-1 axis to regenerate bone in old age

Summary: Aging is associated with increased susceptibility to chronic inflammatory bone loss disorders, such as periodontitis, in large part due to the impaired regenerative potential of aging tissues. DEL-1 exerts osteogenic activity and promotes bone regeneration. However, DEL-1 expression decline...

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Bibliographic Details
Main Authors: Kridtapat Sirisereephap, Hikaru Tamura, Jong-Hyung Lim, Meircurius Dwi Condro Surboyo, Toshihito Isono, Takumi Hiyoshi, Andrea L. Rosenkranz, Yurie Sato-Yamada, Hisanori Domon, Akari Ikeda, Tomoyasu Hirose, Toshiaki Sunazuka, Nagako Yoshiba, Hiroyuki Okada, Yutaka Terao, Takeyasu Maeda, Koichi Tabeta, Triantafyllos Chavakis, George Hajishengallis, Tomoki Maekawa
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:iScience
Subjects:
Immunology
Age
Small molecule
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224000191

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