Application of Environment-Friendly Rhamnolipids against Transmission of Enveloped Viruses Like SARS-CoV2
In the face of new emerging respiratory viruses, such as SARS-CoV2, vaccines and drug therapies are not immediately available to curb the spread of infection. Non-pharmaceutical interventions, such as mask-wearing and social distance, can slow the transmission. However, both mask and social distance...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/2/322 |
| _version_ | 1797395867305508864 |
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| author | Ling Jin Wendy Black Teresa Sawyer |
| author_facet | Ling Jin Wendy Black Teresa Sawyer |
| author_sort | Ling Jin |
| collection | DOAJ |
| description | In the face of new emerging respiratory viruses, such as SARS-CoV2, vaccines and drug therapies are not immediately available to curb the spread of infection. Non-pharmaceutical interventions, such as mask-wearing and social distance, can slow the transmission. However, both mask and social distance have not prevented the spread of respiratory viruses SARS-CoV2 within the US. There is an urgent need to develop an intervention that could reduce the spread of respiratory viruses. The key to preventing transmission is to eliminate the emission of SARS-CoV2 from an infected person and stop the virus from propagating in the human population. Rhamnolipids are environmentally friendly surfactants that are less toxic than the synthetic surfactants. In this study, rhamnolipid products, 222B, were investigated as disinfectants against enveloped viruses, such as bovine coronavirus and herpes simplex virus 1 (HSV-1). The 222B at 0.009% and 0.0045% completely inactivated 6 and 4 log PFU/mL of HSV-1 in 5–10 min, respectively. 222B at or below 0.005% is also biologically safe. Moreover, 50 μL of 222B at 0.005% on ~1 cm<sup>2</sup> mask fabrics or plastic surface can inactivate ~10<sup>3</sup> PFU HSV-1 in 3–5 min. These results suggest that 222B coated on masks or plastic surface can reduce the emission of SARS-CoV2 from an infected person and stop the spread of SARS-CoV2. |
| first_indexed | 2024-03-09T00:42:00Z |
| format | Article |
| id | doaj.art-b4d2982001fd4351a53f33a8205a79ed |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T00:42:00Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-b4d2982001fd4351a53f33a8205a79ed2023-12-11T17:46:48ZengMDPI AGViruses1999-49152021-02-0113232210.3390/v13020322Application of Environment-Friendly Rhamnolipids against Transmission of Enveloped Viruses Like SARS-CoV2Ling Jin0Wendy Black1Teresa Sawyer2Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USADepartment of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USAElectron Microscopy Facility, 145 Linus Pauling Science Center, Oregon State University, Corvallis, OR 97331, USAIn the face of new emerging respiratory viruses, such as SARS-CoV2, vaccines and drug therapies are not immediately available to curb the spread of infection. Non-pharmaceutical interventions, such as mask-wearing and social distance, can slow the transmission. However, both mask and social distance have not prevented the spread of respiratory viruses SARS-CoV2 within the US. There is an urgent need to develop an intervention that could reduce the spread of respiratory viruses. The key to preventing transmission is to eliminate the emission of SARS-CoV2 from an infected person and stop the virus from propagating in the human population. Rhamnolipids are environmentally friendly surfactants that are less toxic than the synthetic surfactants. In this study, rhamnolipid products, 222B, were investigated as disinfectants against enveloped viruses, such as bovine coronavirus and herpes simplex virus 1 (HSV-1). The 222B at 0.009% and 0.0045% completely inactivated 6 and 4 log PFU/mL of HSV-1 in 5–10 min, respectively. 222B at or below 0.005% is also biologically safe. Moreover, 50 μL of 222B at 0.005% on ~1 cm<sup>2</sup> mask fabrics or plastic surface can inactivate ~10<sup>3</sup> PFU HSV-1 in 3–5 min. These results suggest that 222B coated on masks or plastic surface can reduce the emission of SARS-CoV2 from an infected person and stop the spread of SARS-CoV2.https://www.mdpi.com/1999-4915/13/2/322rhamnolipids222A222BHSV-1HSV-1-GFPcoronavirus |
| spellingShingle | Ling Jin Wendy Black Teresa Sawyer Application of Environment-Friendly Rhamnolipids against Transmission of Enveloped Viruses Like SARS-CoV2 Viruses rhamnolipids 222A 222B HSV-1 HSV-1-GFP coronavirus |
| title | Application of Environment-Friendly Rhamnolipids against Transmission of Enveloped Viruses Like SARS-CoV2 |
| title_full | Application of Environment-Friendly Rhamnolipids against Transmission of Enveloped Viruses Like SARS-CoV2 |
| title_fullStr | Application of Environment-Friendly Rhamnolipids against Transmission of Enveloped Viruses Like SARS-CoV2 |
| title_full_unstemmed | Application of Environment-Friendly Rhamnolipids against Transmission of Enveloped Viruses Like SARS-CoV2 |
| title_short | Application of Environment-Friendly Rhamnolipids against Transmission of Enveloped Viruses Like SARS-CoV2 |
| title_sort | application of environment friendly rhamnolipids against transmission of enveloped viruses like sars cov2 |
| topic | rhamnolipids 222A 222B HSV-1 HSV-1-GFP coronavirus |
| url | https://www.mdpi.com/1999-4915/13/2/322 |
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