Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression
Abstract Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) are heterogenous vesicles formed by budding of the cellular membrane, which are se...
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Format: | Article |
Language: | English |
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BMC
2019-03-01
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Series: | Molecular Cancer |
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Online Access: | http://link.springer.com/article/10.1186/s12943-019-0973-7 |
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author | Xiaojie Bian Yu-Tian Xiao Tianqi Wu Mengfei Yao Leilei Du Shancheng Ren Jianhua Wang |
author_facet | Xiaojie Bian Yu-Tian Xiao Tianqi Wu Mengfei Yao Leilei Du Shancheng Ren Jianhua Wang |
author_sort | Xiaojie Bian |
collection | DOAJ |
description | Abstract Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) are heterogenous vesicles formed by budding of the cellular membrane, which are secreted in larger amounts by cancer cells than normal cells. Recently, several reports have also disclosed that MVs function as important mediators of intercellular communication between cancerous and stromal cells within the TME, orchestrating complex pathophysiological processes. Chemokines are a family of small inflammatory cytokines that are able to induce chemotaxis in responsive cells. MVs which selective incorporate chemokines as their molecular cargos may play important regulatory roles in oncogenic processes including tumor proliferation, apoptosis, angiogenesis, metastasis, chemoresistance and immunomodulation, et al. Therefore, it is important to explore the association of MVs and chemokines in TME, identify the potential prognostic marker of tumor, and develop more effective treatment strategies. Here we review the relevant literature regarding the role of MVs and chemokines in TME. |
first_indexed | 2024-04-13T04:56:27Z |
format | Article |
id | doaj.art-b4d2b27de0e3406e9400515cde3e8f6c |
institution | Directory Open Access Journal |
issn | 1476-4598 |
language | English |
last_indexed | 2024-04-13T04:56:27Z |
publishDate | 2019-03-01 |
publisher | BMC |
record_format | Article |
series | Molecular Cancer |
spelling | doaj.art-b4d2b27de0e3406e9400515cde3e8f6c2022-12-22T03:01:29ZengBMCMolecular Cancer1476-45982019-03-0118111310.1186/s12943-019-0973-7Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progressionXiaojie Bian0Yu-Tian Xiao1Tianqi Wu2Mengfei Yao3Leilei Du4Shancheng Ren5Jianhua Wang6Cancer institute, Fudan University Shanghai Cancer Center, Fudan UniversityDepartment of Urology, Shanghai Changhai Hospital, Second Military Medical UniversityCancer institute, Fudan University Shanghai Cancer Center, Fudan UniversityCancer institute, Fudan University Shanghai Cancer Center, Fudan UniversityCancer institute, Fudan University Shanghai Cancer Center, Fudan UniversityDepartment of Urology, Shanghai Changhai Hospital, Second Military Medical UniversityCancer institute, Fudan University Shanghai Cancer Center, Fudan UniversityAbstract Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) are heterogenous vesicles formed by budding of the cellular membrane, which are secreted in larger amounts by cancer cells than normal cells. Recently, several reports have also disclosed that MVs function as important mediators of intercellular communication between cancerous and stromal cells within the TME, orchestrating complex pathophysiological processes. Chemokines are a family of small inflammatory cytokines that are able to induce chemotaxis in responsive cells. MVs which selective incorporate chemokines as their molecular cargos may play important regulatory roles in oncogenic processes including tumor proliferation, apoptosis, angiogenesis, metastasis, chemoresistance and immunomodulation, et al. Therefore, it is important to explore the association of MVs and chemokines in TME, identify the potential prognostic marker of tumor, and develop more effective treatment strategies. Here we review the relevant literature regarding the role of MVs and chemokines in TME.http://link.springer.com/article/10.1186/s12943-019-0973-7MicrovesiclesChemokinesTumor microenvironmentTumor progression |
spellingShingle | Xiaojie Bian Yu-Tian Xiao Tianqi Wu Mengfei Yao Leilei Du Shancheng Ren Jianhua Wang Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression Molecular Cancer Microvesicles Chemokines Tumor microenvironment Tumor progression |
title | Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression |
title_full | Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression |
title_fullStr | Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression |
title_full_unstemmed | Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression |
title_short | Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression |
title_sort | microvesicles and chemokines in tumor microenvironment mediators of intercellular communications in tumor progression |
topic | Microvesicles Chemokines Tumor microenvironment Tumor progression |
url | http://link.springer.com/article/10.1186/s12943-019-0973-7 |
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