Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological Perspectives
Diabetes mellitus (DM) and its complications pose a major public health threat which is approaching epidemic proportions globally. Current drug options may not provide good efficacy and even cause serious adverse effects. Seeking safe and effective agents for DM treatment has been an area of intensi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.748500/full |
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| author | Li-Shan Yan Brian Chi-Yan Cheng Shuo-Feng Zhang Gan Luo Chao Zhang Qing-Gao Wang Xiu-Qiong Fu Yi-Wei Wang Yi Zhang |
| author_facet | Li-Shan Yan Brian Chi-Yan Cheng Shuo-Feng Zhang Gan Luo Chao Zhang Qing-Gao Wang Xiu-Qiong Fu Yi-Wei Wang Yi Zhang |
| author_sort | Li-Shan Yan |
| collection | DOAJ |
| description | Diabetes mellitus (DM) and its complications pose a major public health threat which is approaching epidemic proportions globally. Current drug options may not provide good efficacy and even cause serious adverse effects. Seeking safe and effective agents for DM treatment has been an area of intensive interest. As a healing system originating in Tibet, Traditional Tibetan Medicine (TTM) has been widely used by Tibetan people for the prevention and treatment of DM and its complications for hundreds of years. Tibetan Materia Medica (TMM) including the flower of Edgeworthia gardneri (Wall.) Meisn., Phyllanthi Fructus, Chebulae Fructus, Huidouba, and Berberidis Cortex are most frequently used and studied. These TMMs possess hypoglycemic, anti-insulin resistant, anti-glycation, lipid lowering, anti-inflammatory, and anti-oxidative effects. The underlying mechanisms of these actions may be related to their α-glucosidase inhibitory, insulin signaling promoting, PPARs-activating, gut microbiota modulation, islet β cell-preserving, and TNF-α signaling suppressive properties. This review presents a comprehensive overview of the mode and mechanisms of action of various active constituents, extracts, preparations, and formulas from TMM. The dynamic beneficial effects of the products prepared from TMM for the management of DM and its complications are summarized. These TMMs are valuable materia medica which have the potential to be developed as safe and effective anti-DM agents. |
| first_indexed | 2024-12-16T07:32:11Z |
| format | Article |
| id | doaj.art-b4d48e6dcd4343e792df535f9cdb0a23 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-16T07:32:11Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-b4d48e6dcd4343e792df535f9cdb0a232022-12-21T22:39:18ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-10-011210.3389/fphar.2021.748500748500Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological PerspectivesLi-Shan Yan0Brian Chi-Yan Cheng1Shuo-Feng Zhang2Gan Luo3Chao Zhang4Qing-Gao Wang5Xiu-Qiong Fu6Yi-Wei Wang7Yi Zhang8School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaCollege of Professional and Continuing Education, Hong Kong Polytechnic University, Hong Kong, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaFirst Affiliated Hospital, Guangxi University of Chinese Medicine, Guangxi, ChinaCentre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaDiabetes mellitus (DM) and its complications pose a major public health threat which is approaching epidemic proportions globally. Current drug options may not provide good efficacy and even cause serious adverse effects. Seeking safe and effective agents for DM treatment has been an area of intensive interest. As a healing system originating in Tibet, Traditional Tibetan Medicine (TTM) has been widely used by Tibetan people for the prevention and treatment of DM and its complications for hundreds of years. Tibetan Materia Medica (TMM) including the flower of Edgeworthia gardneri (Wall.) Meisn., Phyllanthi Fructus, Chebulae Fructus, Huidouba, and Berberidis Cortex are most frequently used and studied. These TMMs possess hypoglycemic, anti-insulin resistant, anti-glycation, lipid lowering, anti-inflammatory, and anti-oxidative effects. The underlying mechanisms of these actions may be related to their α-glucosidase inhibitory, insulin signaling promoting, PPARs-activating, gut microbiota modulation, islet β cell-preserving, and TNF-α signaling suppressive properties. This review presents a comprehensive overview of the mode and mechanisms of action of various active constituents, extracts, preparations, and formulas from TMM. The dynamic beneficial effects of the products prepared from TMM for the management of DM and its complications are summarized. These TMMs are valuable materia medica which have the potential to be developed as safe and effective anti-DM agents.https://www.frontiersin.org/articles/10.3389/fphar.2021.748500/fulltibetan material medicadiabetes mellitusinsulin resistancediabetic complicationspharmacology |
| spellingShingle | Li-Shan Yan Brian Chi-Yan Cheng Shuo-Feng Zhang Gan Luo Chao Zhang Qing-Gao Wang Xiu-Qiong Fu Yi-Wei Wang Yi Zhang Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological Perspectives Frontiers in Pharmacology tibetan material medica diabetes mellitus insulin resistance diabetic complications pharmacology |
| title | Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological Perspectives |
| title_full | Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological Perspectives |
| title_fullStr | Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological Perspectives |
| title_full_unstemmed | Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological Perspectives |
| title_short | Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological Perspectives |
| title_sort | tibetan medicine for diabetes mellitus overview of pharmacological perspectives |
| topic | tibetan material medica diabetes mellitus insulin resistance diabetic complications pharmacology |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.748500/full |
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