Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target
Antiplatelet therapy aims to reduce the risk of thrombotic events while maintaining hemostasis. A promising current approach is the inhibition of platelet glycoprotein GPVI-mediated adhesion pathways; pathways that do not involve coagulation. GPVI is a signaling receptor integral for collagen-induce...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/17/9882 |
| _version_ | 1797495208606171136 |
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| author | Eduardo Fuentes |
| author_facet | Eduardo Fuentes |
| author_sort | Eduardo Fuentes |
| collection | DOAJ |
| description | Antiplatelet therapy aims to reduce the risk of thrombotic events while maintaining hemostasis. A promising current approach is the inhibition of platelet glycoprotein GPVI-mediated adhesion pathways; pathways that do not involve coagulation. GPVI is a signaling receptor integral for collagen-induced platelet activation and participates in the thrombus consolidation process, being a suitable target for thrombosis prevention. Considering this, the blocking or antibody-mediated depletion of GPVI is a promising antiplatelet therapy for the effective and safe treatment of thrombotic diseases without a significant risk of bleeding and impaired hemostatic plug formation. This review describes the current knowledge concerning pharmaceutical approaches to platelet GPVI modulation and its downstream signaling pathways in this context. |
| first_indexed | 2024-03-10T01:44:32Z |
| format | Article |
| id | doaj.art-b4d53eb5ddf6480cb9ef42da3e49b5ac |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:44:32Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b4d53eb5ddf6480cb9ef42da3e49b5ac2023-11-23T13:18:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012317988210.3390/ijms23179882Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet TargetEduardo Fuentes0Thrombosis Research Center, Medical Technology School, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences, Universidad de Talca, Talca 3480094, ChileAntiplatelet therapy aims to reduce the risk of thrombotic events while maintaining hemostasis. A promising current approach is the inhibition of platelet glycoprotein GPVI-mediated adhesion pathways; pathways that do not involve coagulation. GPVI is a signaling receptor integral for collagen-induced platelet activation and participates in the thrombus consolidation process, being a suitable target for thrombosis prevention. Considering this, the blocking or antibody-mediated depletion of GPVI is a promising antiplatelet therapy for the effective and safe treatment of thrombotic diseases without a significant risk of bleeding and impaired hemostatic plug formation. This review describes the current knowledge concerning pharmaceutical approaches to platelet GPVI modulation and its downstream signaling pathways in this context.https://www.mdpi.com/1422-0067/23/17/9882glycoprotein VIplateletthrombosisbleedingpathways |
| spellingShingle | Eduardo Fuentes Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target International Journal of Molecular Sciences glycoprotein VI platelet thrombosis bleeding pathways |
| title | Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target |
| title_full | Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target |
| title_fullStr | Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target |
| title_full_unstemmed | Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target |
| title_short | Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target |
| title_sort | modulation of glycoprotein vi and its downstream signaling pathways as an antiplatelet target |
| topic | glycoprotein VI platelet thrombosis bleeding pathways |
| url | https://www.mdpi.com/1422-0067/23/17/9882 |
| work_keys_str_mv | AT eduardofuentes modulationofglycoproteinvianditsdownstreamsignalingpathwaysasanantiplatelettarget |